Protein Alignment KIN2 and par-1

DIOPT Version :9

• Sequence 1: NP_013197.1
• Gene: KIN2 / 850785
• SGDID: S000004086
• Length: 1147
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 1151
• Identity: 270/1151 - (23%)
• Similarity: 438/1151 - (38%)
• Gaps: 290/1151 - (25%)

Yeast    62 PADIKQGKEQAAQRQNDASRPNGAVELRQFHRRSLGDWEFLETVGAGSMGKVKLVKHRQTKEICV 126
            |:.|||....|....|...|.:..:..|..... :|.::.::|:|.|:..||||.||..|.:...
  Fly   217 PSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEH-IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVA 280

Yeast   127 IKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEM 191
            |||:::             :..|...:              ::..||..:.::|.||:|.:||::
  Fly   281 IKIIDK-------------TQLNPGSL--------------QKLFREVRIMKMLDHPNIVKLFQV 318

Yeast   192 CTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMI 256
            .......|::.||.|||::.||::.||.:||..||...|.|.||:||.|...|:|||||.||:::
  Fly   319 IETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLL 383

Yeast   257 SSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKV 321
            .|...|||.|||.||.|....:|.|||||..:|||||.:.:.|.|||||:||.|::||.||.|.:
  Fly   384 DSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSL 448

Yeast   322 PFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGY--DFK 384
            |||......|.|::.:||...|.::|.:..:||.:.:|::|.:||:|:.::...|||.|:  |..
  Fly   449 PFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDEL 513

Yeast   385 APSYVPNRVPLTPEMIDSQVLKEMYRLEF--------IDDIEDTRRSLIRLVTEKEYIQLSQEYW 441
            .|...|......|:.|::.|.....|.|.        .||:..|            |:.|.::..
  Fly   514 KPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFAT------------YLLLGRKST 566

Yeast   442 DKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEPDSNFEDPTLAYHPLLSIYHLVS 506
            |..|:.....|||:            ::| |:.|  .:|.|...::.:.||         :..|.
  Fly   567 DPESDGSRSGSSLS------------LRN-ISGN--DAGANAGSASVQSPT---------HRGVH 607

Yeast   507 EMVARKLAKLQRR--------QALALQAQAQQRQQQQQVALGTKVALNN---------------- 547
            ..::....|..||        .|.|..|.|..       |:|.....||
  Fly   608 RSISASSTKPSRRASSGVGPTNAAATVAAATG-------AVGAVNPSNNYNAAGSAADRASVGSN 665

Yeast   548 ----NSPDIMTKMRSPQKEVVPNPGIFQVPAIGTS---GTSNNT-NTSNKPPLHVMVPP---KLT 601
                |:.|..|...:..:....|    |.||..|.   .|::.| |:..||.......|   ..|
  Fly   666 FKRQNTIDSATIKENTARLAAQN----QRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRT 726

Yeast   602 IPEQAHTSPTSRKSSDIHTELNGVLKSTPVPVSGEY--QQRSASPV-----------------VG 647
            :...:...|  |:|:.::.:.:...|:..:|.....  :.|.||.|                 .|
  Fly   727 VSGTSGIIP--RRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSG 789

Yeast   648 EHQEKNTIGGIFRRIS-QSGQSQHPTRQQEPLPEREPPTYMSKSNEISIKVPKSHSRTISDYIPS 711
            :.:.:|.....:...| .||.|.||.|.          ::.||.:....|.|     ||:|
  Fly   790 QTRARNNTALEYSGTSGASGDSSHPGRM----------SFFSKLSSRFSKRP-----TIAD---- 835

Yeast   712 ARRYPSYVPNSVDVKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQRQKLLQENLDKL 776
                            :.||     |.:...:....:..|.:|   :.|:||.|:.|.|.|.|..
  Fly   836 ----------------EAAK-----PRVLRFTWSMKTTSPLMP---DQIMQKIREVLDQNNCDYE 876

Yeast   777 QINDNDNNNVNAVVDGINND-NSDHY----LSVPKGRKLHPSARAKSVGHARRESLKFTRPPIPA 836
            |       ....|:..::.| |:|..    :.|.|..:|       |:...|.:.:..|
  Fly   877 Q-------RERFVLWCVHGDPNTDSLVQWEIEVCKLPRL-------SLNGVRFKRISGT------ 921

Yeast   837 ALPPSDMTNDNGF-----LGEANKERYNPVSSNFSTVPEDSTTY------SNDTNNRLT--SVYS 888
            ::...::.:...|     |.:.|.|.....:::..|.|.|:.|.      |||:.:||:  |:..
  Fly   922 SIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLC 986

Yeast   889 QELTEKQILEEASKAPPGSMPSIDYPKSMFLKGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKE 953
            :.||.:|..:...|:...:..|.|..||..|...|.:.:..|              ::.|:...|
  Fly   987 RSLTSQQGSQRRKKSRLSTGGSEDQKKSNSLLSAFQMYSPFS--------------SKENMQSSE 1037

Yeast   954 VKGGFICVQQRP--SIETAAV-------PVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTASSA 1009
            .......:..:|  |::....       |::.....|::.||..:              :...|.
  Fly  1038 EVEDLHVIDTQPGHSVDVPLFADFSPINPIMEEDAEGVEGGKTSE--------------AKVISG 1088

Yeast  1010 SRNSSIKRQGSYKRGQNNIPLTPLATNTHQRNSSIPMSPNYGNQSNG-TSGELSSMSLDYVQQQD 1073
            .....:|..|....|.|.     |..|.....|.|......|..::. ..|.:....    ::|.
  Fly  1089 GSGQKVKGDGGGGGGGNR-----LKRNIKHTGSLIVRKLTAGRHNDADKKGAIRKKD----KEQQ 1144

Yeast  1074 DILTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVKVRIVGL 1119
            ::..|.                    ||||..|.|..:..:|...|
  Fly  1145 EVADTD--------------------KERPTSKPEGKVAMLRTTTL 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIN2	NP_013197.1	STKc_Kin1_2	97..377	CDD:270979	103/279 (37%)
		KA1	1104..1147	CDD:396635	4/16 (25%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	102/278 (37%)
		S_TKc	253..504	CDD:214567	102/277 (37%)
		UBA_MARK_Par1	525..563	CDD:270522	10/49 (20%)
		MARK1-3_C	839..936	CDD:213381	24/124 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I646
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	1	1.000	-	-		X401
TreeFam	0	0.000	Not matched by this tool.
	3	3.080