Protein Alignment KIN2 and par-1

DIOPT Version :10

• Sequence 1: NP_013197.1
• Gene: KIN2 / 850785
• SGDID: S000004086
• Length: 1147
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 1149
• Identity: 269/1149 - (23%)
• Similarity: 434/1149 - (37%)
• Gaps: 286/1149 - (24%)

Yeast    62 PADIKQGKEQAAQRQNDASRPNGAVELRQFHRRSLGDWEFLETVGAGSMGKVKLVKHRQTKEICV 126
            |:.|||....|....|...|.:..:..|..... :|.::.::|:|.|:..||||.||..|.:...
  Fly   217 PSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEH-IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVA 280

Yeast   127 IKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEM 191
            |||:::             :..|...:              ::..||..:.::|.||:|.:||::
  Fly   281 IKIIDK-------------TQLNPGSL--------------QKLFREVRIMKMLDHPNIVKLFQV 318

Yeast   192 CTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMI 256
            .......|::.||.|||::.||::.||.:||..||...|.|.||:||.|...|:|||||.||:::
  Fly   319 IETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLL 383

Yeast   257 SSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKV 321
            .|...|||.|||.||.|....:|.|||||..:|||||.:.:.|.|||||:||.|::||.||.|.:
  Fly   384 DSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSL 448

Yeast   322 PFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGY--DFK 384
            |||......|.|::.:||...|.::|.:..:||.:.:|::|.:||:|:.::...|||.|:  |..
  Fly   449 PFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDEL 513

Yeast   385 APSYVPNRVPLTPEMIDSQVLKEMYRLEF--------IDDIEDTRRSLIRLVTEKEYIQLSQEYW 441
            .|...|......|:.|::.|.....|.|.        .||:..|            |:.|.::..
  Fly   514 KPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFAT------------YLLLGRKST 566

Yeast   442 DKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEPDSNFEDPTLAYHPLLSIYHLVS 506
            |..|:.....|||:            ::| |:.|  .:|.|...::.:.||         :..|.
  Fly   567 DPESDGSRSGSSLS------------LRN-ISGN--DAGANAGSASVQSPT---------HRGVH 607

Yeast   507 EMVARKLAKLQRR--------QALALQAQAQQRQQQQQVALGTKVALNN---------------- 547
            ..::....|..||        .|.|..|.|..       |:|.....||
  Fly   608 RSISASSTKPSRRASSGVGPTNAAATVAAATG-------AVGAVNPSNNYNAAGSAADRASVGSN 665

Yeast   548 ----NSPDIMTKMRSPQKEVVPNPGIFQVPAIGTSGTSNNTNTSNKPPLHVMVPPKLTIPEQAHT 608
                |:.|..|...:..:....|    |.||..|.......:|:...|.......|........|
  Fly   666 FKRQNTIDSATIKENTARLAAQN----QRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRT 726

Yeast   609 -SPTS----RKSSDIHTELNGVLKSTPVPVSGEY--QQRSASPV-----------------VGEH 649
             |.||    |:|:.::.:.:...|:..:|.....  :.|.||.|                 .|:.
  Fly   727 VSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQT 791

Yeast   650 QEKNTIGGIFRRIS-QSGQSQHPTRQQEPLPEREPPTYMSKSNEISIKVPKSHSRTISDYIPSAR 713
            :.:|.....:...| .||.|.||.|.          ::.||.:....|.|     ||:|
  Fly   792 RARNNTALEYSGTSGASGDSSHPGRM----------SFFSKLSSRFSKRP-----TIAD------ 835

Yeast   714 RYPSYVPNSVDVKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQRQKLLQENLDKLQI 778
                          :.||     |.:...:....:..|.:|   :.|:||.|:.|.|.|.|..|
  Fly   836 --------------EAAK-----PRVLRFTWSMKTTSPLMP---DQIMQKIREVLDQNNCDYEQ- 877

Yeast   779 NDNDNNNVNAVVDGINND-NSDHY----LSVPKGRKLHPSARAKSVGHARRESLKFTRPPIPAAL 838
                  ....|:..::.| |:|..    :.|.|..:|       |:...|.:.:..|      ::
  Fly   878 ------RERFVLWCVHGDPNTDSLVQWEIEVCKLPRL-------SLNGVRFKRISGT------SI 923

Yeast   839 PPSDMTNDNGF-----LGEANKERYNPVSSNFSTVPEDSTTY------SNDTNNRLT--SVYSQE 890
            ...::.:...|     |.:.|.|.....:::..|.|.|:.|.      |||:.:||:  |:..:.
  Fly   924 GFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLCRS 988

Yeast   891 LTEKQILEEASKAPPGSMPSIDYPKSMFLKGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKEVK 955
            ||.:|..:...|:...:..|.|..||..|...|.:.:..|              ::.|:...|..
  Fly   989 LTSQQGSQRRKKSRLSTGGSEDQKKSNSLLSAFQMYSPFS--------------SKENMQSSEEV 1039

Yeast   956 GGFICVQQRP--SIETAAV-------PVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTASSASR 1011
            .....:..:|  |::....       |::.....|::.||..:              :...|...
  Fly  1040 EDLHVIDTQPGHSVDVPLFADFSPINPIMEEDAEGVEGGKTSE--------------AKVISGGS 1090

Yeast  1012 NSSIKRQGSYKRGQNNIPLTPLATNTHQRNSSIPMSPNYGNQSNG-TSGELSSMSLDYVQQQDDI 1075
            ...:|..|....|.|.     |..|.....|.|......|..::. ..|.:....    ::|.::
  Fly  1091 GQKVKGDGGGGGGGNR-----LKRNIKHTGSLIVRKLTAGRHNDADKKGAIRKKD----KEQQEV 1146

Yeast  1076 LTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVKVRIVGL 1119
            ..|.                    ||||..|.|..:..:|...|
  Fly  1147 ADTD--------------------KERPTSKPEGKVAMLRTTTL 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIN2	NP_013197.1	STKc_Kin1_2	97..377	CDD:270979	103/279 (37%)
		KA1	1104..1147	CDD:460465	4/16 (25%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	102/278 (37%)
		UBA_MARK_Par1	525..563	CDD:270522	10/49 (20%)
		MARK1-3_C	839..936	CDD:213381	24/124 (19%)