DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PML1 and CG17168

DIOPT Version :9

Sequence 1:	NP_013116.1	Gene:	PML1 / 850703	SGDID:	S000004006	Length:	204	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001015254.1	Gene:	CG17168 / 3354996	FlyBaseID:	FBgn0039943	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	243	Identity:	61/243 - (25%)
Similarity:	91/243 - (37%)	Gaps:	89/243 - (36%)

- Green bases have known domain annotations that are detailed below.

Yeast     4 RRKRPYNTRNYGHDDKKFKSQYID-------------IMPDFSPSGLLELESNNKEGIALKHVEP 55
            :|.:.:|..|...||.....:.:|             ..|:|..||.|..::|...|:.:|:.||
  Fly   207 QRNQRHNNSNKNEDDHYVWGKEVDEKVPAENDVPVDKEKPNFGLSGALTEDTNKLNGVVVKYSEP 271

Yeast    56 QDAISPDNYMDMLGLEARDRTMYELVIYRKNDKDKGPWKRYDLNG-----------RSCYLVGRE 109
            .:|..|                            |..|:.|...|           :||:||||
  Fly   272 PEARKP----------------------------KRRWRLYPFKGETALPTLHIHRQSCFLVGR- 307

Yeast   110 LGHSLDTDLDDRTEIVVADIGIPEETSSKQHCVIQFRNV--------RG-ILKCYVMDLDSSNGT 165
                      ||.   |.|:.:...:.||||..:|:|.|        .| .::.|::||||:|||
  Fly   308 ----------DRK---VVDLAVDHPSCSKQHAALQYRLVPFEREDGSHGKRVRLYLIDLDSANGT 359

Yeast   166 CLNNVVIPGARYIELRSGDVLTL--------------SEFEEDNDYEL 199
            .|||..|...:|.||...||:..              .|.:||:|..:
  Fly   360 FLNNKKIDARKYYELIEKDVIKFGFSSREYVLLHENSKEDQEDDDVHI 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PML1	NP_013116.1	FHA	85..192	CDD:238017	40/140 (29%)
CG17168	NP_001015254.1	FHA	280..395	CDD:238017	38/128 (30%)
CG17168	NP_001015254.1	FHA	<294..411	CDD:224630	39/128 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344073
Domainoid	1	1.000	47	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG1882
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004489
OrthoInspector	1	1.000	-	-		oto99860
orthoMCL	1	0.900	-	-		OOG6_102703
Panther	1	1.100	-	-	LDO	PTHR23308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2234
SonicParanoid	1	1.000	-	-		X4267
TreeFam	0	0.000	Not matched by this tool.
	11	10.770