Protein Alignment CNTNAP1 and axo

DIOPT Version :10

• Sequence 1: NP_003623.1
• Gene: CNTNAP1 / 8506
• HGNCID: 8011
• Length: 1384
• Species: Homo sapiens
• Sequence 2: NP_001246631.1
• Gene: axo / 43923
• FlyBaseID: FBgn0262870
• Length: 2179
• Species: Drosophila melanogaster
• Alignment Length: 1210
• Identity: 274/1210 - (22%)
• Similarity: 464/1210 - (38%)
• Gaps: 240/1210 - (19%)

Human   126 NVNES----AVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYK--------ADILYFD 178
            ||||.    ...||:|.| ..:|.|       |..|  |:....:|..|:        |.|:...
  Fly   433 NVNEGCSDMCESRHNLCF-VGSRCI-------NHYG--GISCDCFGTHYEGEHCDIYTATIITLR 487

Human   179 GDDAISYRFPRGVSR--SLWDVFAFSFKTEEKDGLLLHAEG--AQGDYVTLELEGAHLLLHMSLG 239
            |...:|||......|  |.....:..|:|...|..|.:|.|  .:..|:...::...:.:.|..|
  Fly   488 GASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFG 552

Human   240 SSPIQPRPGHTTVSAGGVLNDQ----HWHYVRVDRFGRDVNFTLDGYVQRFIL------NGDFER 294
            .:.:..           ||.|.    :||.:.:....|.|:..||  .|:.:|      :|:
  Fly   553 DNVMST-----------VLTDDLTRGYWHNLTILHEQRTVSIILD--QQQKVLELPATASGN--- 601

Human   295 LNLDTEMFIGGLVGA---ARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCL 356
            :..|.|::.||  |.   .:|.||..:||.|.::.|.:|.::|.....|.:.::.:.|.:....:
  Fly   602 MLFDPEIYFGG--GPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRGNPKVHYHGVLEAEFV 664

Human   357 D------PVPHPI---NFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRL----GDGLG 408
            :      |:.:|.   :...|.|..:        ...:.|.||:.....:|.:|.:    |:|..
  Fly   665 ENEVNVIPITYPFATSHIWWPINHAE--------EFNIKFDFRSSRPGAVLAYSDVTTSAGNGFW 721

Human   409 HVELTLSE------GQVNVSIAQSGRKKLQFAAGYRLNDGFWH---------EVNFVAQENHAVI 458
            .:.||..:      ..||.::..|...|:..|..       ||         |:.|.....|.:.
  Fly   722 EIRLTSDKLSFDLVPDVNNNVTHSTTIKINRATS-------WHSVELDYKLGEIRFTVDYRHTLS 779

Human   459 SIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVN-LTLV 522
            .:           |.|....|.....|...|.|:        ....||:..::::|.|:. ..:|
  Fly   780 QM-----------YGLTFNIGDKLIIGSSLKSAA--------MGLVGCIRDIEINGHLIEPRHVV 825

Human   523 EGRRLGFYAEVLFDTCGITDRCS-PNMCEHDGRCYQSWDDFICYCELTGYKGETCHTPLYKESCE 586
            :..|:  ..||..|.|...|.|. ||.|||.|:|:...|...|.|:.|||.|:.||...|:::||
  Fly   826 KTERV--VGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCE 888

Human   587 AYRLSGKTSGN-FTIDPDGSGPLKPFVVYCDIR--ENRAWTVVRHDRLWTTRVTGSSMERPFLGA 648
            ...|.|.|..: :.||.||:|...|..|.||.:  ||...|:|.|: |.:.....|:.|..|...
  Fly   889 ELALLGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHN-LPSQVDVRSARESDFSFN 952

Human   649 IQYWNASWEEVSALANASQHCEQWIEFSCYNSRL-LNTAGGYPYSFWIGRNEEQHFYWGGSQPGI 712
            |:|...|...:..|.:.|.:|.|:|::.||.::| |::|..:..|   .:|....|. |..:.|
  Fly   953 IRYREFSPHMLQELISHSLYCTQYIKYDCYRAQLELHSATWFTSS---AKNLTVDFL-GNVKRG- 1012

Human   713 QRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQ--FFLRP 775
             .|.|.::::||||...||||..:.:|.:|:|.......|.:|.:..........|||  ..|.|
  Fly  1013 -ACPCSVNKTCVDPNQSCNCDVKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGRITLGP 1076

Human   776 LRCYGDRNSWNTISFHTGAA-LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVR 839
            |.|.........::|.|..: :..|..|..   |::|.|||:....:.|..   |..:...|...
  Fly  1077 LECVETNTQKYVVTFTTSQSYIEVPGWRKG---DIAFSFRTTGEKAILLFQ---PPIRPHYPSFM 1135

Human   840 VELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQ 904
            |.|.....:.|.|.:..|.....|.:.....|..|||.:..:.|....|..::....:|..:|.:
  Fly  1136 VALTGDDQLTFTFTLSTGTTRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTDYQMLDLLPEE 1200

Human   905 TYIWMEYDQPLYVGSAE---LK----RRPFVGCLRAMRLNGVTLNLEG--RANASE---GTSPNC 957
            .:  ..::..:|:|.|.   ||    :...:||.|.:.:||..|::..  ..:.||   ...|:|
  Fly  1201 EF--GPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSC 1263

Human   958 TGHCAHPRLPCFHGGRCVERYSYYTCDCDLT-AFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAA 1021
            ...      ||.:|.:|.|.:|.:.|.|:.. |..|.:|..:|.             :.||....
  Fly  1264 VPS------PCRNGAQCKELWSSFKCVCNNPWAHIGEFCETNIN-------------EKALTFIN 1309

Human  1022 REFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSF 1086
            ||  ..|.|       .|:....||  |...||              :.|.|..:..:..:::..
  Fly  1310 RE--SFLMR-------NYLSVGATP--VILMHG--------------INGERDVLKGILNQDLLI 1349

Human  1087 SFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVT---DGQPHSINI 1148
            :..|....|::||.:....:::.:.|..:..:...|..|..  :..||....|   ..:...:.|
  Fly  1350 NLRTYDTNALVLYANDHYNNFVHLYISLNREIVFLYNYGDE--IVNLTLLDDTLMASLKSIQVAI 1412

Human  1149 TRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKA---------------------LYLGRVMETG 1192
            .|..:...:.|:...::..:.:||:|...:.|.:                     .::|......
  Fly  1413 VRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPAN 1477

Human  1193 VIDPEIQRYNTPGFSGCLSGVRF------------NNVAP 1220
            ::.|.:......|:.||:.|::.            .|:||
  Fly  1478 LLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAP 1517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNTNAP1	NP_003623.1	FA58C	36..167	CDD:238014	13/44 (30%)
		LamG	175..330	CDD:238058	39/171 (23%)
		LamG	362..513	CDD:238058	30/172 (17%)
		EGF	544..575	CDD:394967	15/31 (48%)
		FReD	584..>658	CDD:412152	26/76 (34%)
		GGGWT_bact	584..>616	CDD:468872	12/32 (38%)
		LamG	787..937	CDD:238058	34/157 (22%)
		Laminin_G_2	1088..1218	CDD:460494	23/165 (14%)
		4.1m	1304..1322	CDD:128590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1319..1384
		SH3-binding. /evidence=ECO:0000255	1328..1369
axo	NP_001246631.1	Kunitz-type	119..170	CDD:438633
		Laminin_G_2	275..413	CDD:460494
		EGF_CA	433..476	CDD:238011	15/52 (29%)
		Laminin_G_2	514..640	CDD:460494	34/143 (24%)
		Laminin_G_2	698..817	CDD:460494	26/144 (18%)
		EGF_CA	842..878	CDD:238011	16/35 (46%)
		Laminin_G_2	1112..1240	CDD:460494	29/132 (22%)
		EGF_CA	1256..1297	CDD:238011	12/46 (26%)
		Laminin_G_2	1351..1503	CDD:460494	23/153 (15%)
		Laminin_G_2	1612..1733	CDD:460494
		PHA03247	<1895..2164	CDD:223021