Protein Alignment PEX3 and PEX3

DIOPT Version :10

• Sequence 1: NP_003621.1
• Gene: PEX3 / 8504
• HGNCID: 8858
• Length: 373
• Species: Homo sapiens
• Sequence 2: NP_010616.3
• Gene: PEX3 / 851929
• SGDID: S000002737
• Length: 441
• Species: Saccharomyces cerevisiae
• Alignment Length: 436
• Identity: 84/436 - (19%)
• Similarity: 166/436 - (38%)
• Gaps: 90/436 - (20%)

Human     7 NFLKRHKKKCIFLGTVLGGVYILGK----YGQKKIREIQEREAAEYIAQARRQYHFESNQRTCNM 67
            :.|:||:.|.:...|.:..::..|.    :.::.:.:.|.|...::..:.:.:..||..|.....
Yeast     9 SLLQRHRGKVLISLTGIAALFTTGSVVVFFVKRWLYKQQLRITEQHFIKEQIKRRFEQTQEDSLY 73

Human    68 TVLSMLPTLREALMQ-QLNSESLTALLKNRPS-----------------NKLEIWEDLKIISFTR 114
            |:..:||..|..|.: .||.:|:...||::.:                 :|.|:|.:|::.|..:
Yeast    74 TIYELLPVWRMVLNENDLNLDSIVTQLKDQKNQLTRAKSSESRESSPLKSKAELWNELELKSLIK 138

Human   115 STVAVYSTCMLVVLLRVQLNIIGGYIYLDNA---------------------------------- 145
            .....|:...|::|.|:||||:....|||:|
Yeast   139 LVTVTYTVSSLILLTRLQLNILTRNEYLDSAIKLTMQQENCNKLQNRFYNWVTSWWSDPEDKADD 203

Human   146 -------AVGKNGTTILAPPDVQQQYLSSIQHLLGDGLTELITVIKQAVQKVLGSVSLKHSLSLL 203
                   ...|.|..:...   :|.:||....:|..|......:|...::.....:..:.:|:|.
Yeast   204 AMVMAAKKSKKEGQEVYIN---EQAFLSLSWWILNKGWLSYNEIITNQIEIEFDGIHPRDTLTLE 265

Human   204 DLEQKLKEI-RNLVEQ-------HKSSSWINKD--GSKPLLCHYMMPDEETPLAVQACGLSPRDI 258
            :...:|..| ||...|       :.:|..:.||  |.:.||...:..|..|       ......:
Yeast   266 EFSSRLTNIFRNTNSQIFQQNNNNLTSILLPKDSSGQEFLLSQTLDADALT-------SFHSNTL 323

Human   259 TTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMA----EFFRPTEQDLQHGNSMNSLSSVS 319
            ...:|:||....:||...|.||.:.:|..|..:::.:.    ...:|.::|.|.........|:.
Yeast   324 VFNQLVNELTQCIESTATSIVLESLINESFHFIMNKVGIKTIAKKKPGQEDQQQYQMAVFAMSMK 388

Human   320 LPLAKIIPIVNGQIHSVCSETPSHFVQDLLTMEQVKDFAANVYEAF 365
            ....:::....|..|   |.:.:.::..|.:::.:.|.:|:||..|
Yeast   389 DCCQEMLQTTAGSSH---SGSVNEYLATLDSVQPLDDLSASVYSNF 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX3	NP_003621.1	Targeting to peroxisomes. /evidence=ECO:0000269|PubMed:11390669	1..45		8/41 (20%)
		Peroxin-3	11..362	CDD:428171	80/427 (19%)
		Interaction with PEX19. /evidence=ECO:0000269|PubMed:11390669	120..136		7/15 (47%)
PEX3	NP_010616.3	Peroxin-3	13..430	CDD:428171	83/432 (19%)