Protein Alignment PEX3 and Pex3

DIOPT Version :10

• Sequence 1: NP_003621.1
• Gene: PEX3 / 8504
• HGNCID: 8858
• Length: 373
• Species: Homo sapiens
• Sequence 2: NP_648753.1
• Gene: Pex3 / 39652
• FlyBaseID: FBgn0036484
• Length: 385
• Species: Drosophila melanogaster
• Alignment Length: 411
• Identity: 138/411 - (33%)
• Similarity: 212/411 - (51%)
• Gaps: 71/411 - (17%)

Human     1 MLRSVWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKIREIQEREAAEYIAQARRQYHFESNQRTC 65
            ||..:.:||.||::|.|..|.::||.....:|.|::..|.||::|.|:..:.||..||||.::||
  Fly     1 MLSRLQDFLSRHRRKFIVTGVLVGGTIFAARYAQRRFVEFQEKQAREFFERTRRTTHFESTEKTC 65

Human    66 NMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKIISFTRSTVAVYSTCMLVVLLR 130
            |..:|.|...:.:|::::.:::.|...|:..|.||||:|||:||::|||....||::.|||:.||
  Fly    66 NQVILGMGEEMCQAVLRECSTDELLEQLRQNPKNKLELWEDMKIVAFTRLATYVYASSMLVIALR 130

Human   131 VQLNIIGGYIYLDNAAVGKNGTTILAPPDVQQQYLSSIQHLLGD-GLTELITVIKQAVQKVLGSV 194
            ||||::|||||.|.....|..|     .:::|||||.|:|.:.| |:.:|...|:..|..|..::
  Fly   131 VQLNLLGGYIYRDIMTEQKQVT-----DELKQQYLSLIRHFITDSGIRDLARYIRTQVIAVTKTI 190

Human   195 SLKHSLSLLDLEQ---KLKEIRNLVEQHKSSSWINKDGSKPLLCHYMMPDE---ETPLAVQACGL 253
            .|...|||.||||   .|:...|...:...:|.::|         |::|.:   .:||..
  Fly   191 PLSEQLSLSDLEQLFWSLQMAINADTRRDPNSRMSK---------YLLPSQNPSHSPLLQ----- 241

Human   254 SPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMAEFFRPTEQDL------------ 306
                    |::|||.|:|||.|...|.:..::|||....|.:||....|.|.|
  Fly   242 --------KMVNETLDLLESEDAVGVCSHNVSRGFVLACDAIAESMGETLQHLPQAKVQTQQEQS 298

Human   307 ----------------QHG---NSMNSLSSVSLPLAKIIPIVNGQIHSVCSET--PSHFVQDLLT 350
                            |:|   |::.:::.|.|.|||:|||::|........|  |.:....|||
  Fly   299 VKFNQAGSLGASTSKSQNGLENNNLLNINRVLLALAKLIPIISGLTSRGFDTTSRPHNLPTQLLT 363

Human   351 M----EQVKDFAANVYEAFST 367
            .    |:.|...|||||:||:
  Fly   364 FYVVAEKTKTLGANVYESFSS 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX3	NP_003621.1	Targeting to peroxisomes. /evidence=ECO:0000269|PubMed:11390669	1..45		16/43 (37%)
		Peroxin-3	11..362	CDD:428171	129/394 (33%)
		Interaction with PEX19. /evidence=ECO:0000269|PubMed:11390669	120..136		10/15 (67%)
Pex3	NP_648753.1	Peroxin-3	11..301	CDD:428171	108/316 (34%)