Protein Alignment PEX3 and pex3

DIOPT Version :10

• Sequence 1: NP_003621.1
• Gene: PEX3 / 8504
• HGNCID: 8858
• Length: 373
• Species: Homo sapiens
• Sequence 2: NP_594868.2
• Gene: pex3 / 2541734
• PomBaseID: SPAC29A4.14C
• Length: 346
• Species: Schizosaccharomyces pombe
• Alignment Length: 394
• Identity: 91/394 - (23%)
• Similarity: 156/394 - (39%)
• Gaps: 80/394 - (20%)

Human     1 MLRSVWNFLKRHKKKC--IFLGTVLGGVYILGKYG-----QKKIREIQE--REAAEYI------- 49
            ||:|....|....:||  ..||:   .:.:||.|.     :....|..|  ...::|:
pombe     1 MLKSFEKHLNAVSRKCCNFILGS---SIPVLGFYCADTCIRNAFMEFMETRNSKSKYVEAFNTVQ 62

Human    50 ----AQARRQYHFESNQRTCNMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKII 110
                ..|...:|...::....:.:|.::..|||..|.::::|           .|:.:|..||.:
pombe    63 SNGATSAISTFHILKDEIIRRIPLLPIIQELRETRMSEVSAE-----------EKILLWNQLKFM 116

Human   111 SFTR--STVAVYSTCMLVVLLRVQLNIIGGYIYLDNAAVGKNGTTILAP--PDVQQQYLSSIQH- 170
            |..|  :|:||.:.|.|  |.::.|.::|...:.:......:.:..|.|  .|......:.|.:
pombe   117 SLVRMFTTLAVLAQCNL--LCKLALTVLGREAFKEQMVKEFDPSNTLRPSGSDEDPAVFTGIAYI 179

Human   171 LLGDGLTELITVIKQAVQKVLGSVSLKHSLSLLDLEQKLKE--IRNLVEQHKSSSWINKDGSKPL 233
            ||.:.|.|||..::.||......||   ...::|  :||.|  ...:||...::...:.||:|.:
pombe   180 LLNNQLDELIQQVQLAVTLTFEEVS---PTDIVD--RKLIEALTTRVVEVFVNNYQFSIDGNKEV 239

Human   234 LCHYMMPDEETPLAVQACGLSPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMAEF 298
            |.      .|.|         .:.|.|..||..   :||..||:|.::.      |.::.|  |.
pombe   240 LL------AEIP---------KQYIVTGNLLYR---VLELEDFATQMDA------SIVMKN--EL 278

Human   299 FRPTEQDLQHGNSMNSLSSVSLPLAKIIPIVNGQIHSVCSETP--SHFVQDLLTMEQVKDFAANV 361
            ....|..|.:   :.|:....:.||||:.... :|.....|.|  ..|.|.|..:..|..:.|.|
pombe   279 IALNEHMLTY---LPSIPQEGIRLAKILTTFT-KISENVFEAPFQEQFFQSLQMVSDVNRYMAIV 339

Human   362 YEAF 365
            :.:|
pombe   340 FSSF 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX3	NP_003621.1	Targeting to peroxisomes. /evidence=ECO:0000269|PubMed:11390669	1..45		13/52 (25%)
		Peroxin-3	11..362	CDD:428171	85/379 (22%)
		Interaction with PEX19. /evidence=ECO:0000269|PubMed:11390669	120..136		4/15 (27%)
pex3	NP_594868.2	Peroxin-3	<106..>221	CDD:428171	32/121 (26%)