Protein Alignment PEX3 and prx-3

DIOPT Version :10

• Sequence 1: NP_003621.1
• Gene: PEX3 / 8504
• HGNCID: 8858
• Length: 373
• Species: Homo sapiens
• Sequence 2: NP_001123111.1
• Gene: prx-3 / 182644
• WormBaseID: WBGene00004193
• Length: 353
• Species: Caenorhabditis elegans
• Alignment Length: 398
• Identity: 94/398 - (23%)
• Similarity: 166/398 - (41%)
• Gaps: 79/398 - (19%)

Human     1 MLRSVWNFLKRHKKKCIFLGTVLGG--VYILGKYGQKKIREIQEREAAEYIAQARRQYHFESNQR 63
            ||.|.|.|.||:|.|.|..|.::|.  .|:......|.:.::.  .::|...||||.|.|:|..|
 Worm     1 MLASAWEFAKRNKGKIIAGGVLVGSAIAYVQSSSRPKTLEKVS--TSSELPNQARRHYIFDSTHR 63

Human    64 TCNMTVLSMLPTLREALMQQLNSESLTALLKNRP----SNKLEIWEDLKIISFTRSTVAVYSTCM 124
            :|:.::..::|::...:..:.:.||:...|:|.|    ..|:::||.||..:|.|.....:...:
 Worm    64 SCDQSITDLIPSIVTQIQARFDVESIQEKLQNTPDLTAEQKMQLWEQLKKNAFCRIVSVAFGFSI 128

Human   125 LVVLLRVQLNIIG-----------------GYI-----YLDNAAVGKNGTTILAPPD------VQ 161
            |.:.|:.|::|:.                 .||     .:.|:..|.||   |:|.|      .:
 Worm   129 LTLTLKAQISILAADTCSQFEQRNKKPTWQNYIPESMNSMWNSRTGSNG---LSPTDNPMDVGNR 190

Human   162 QQYLSSIQHLLGDGLTELITVIKQAVQKVLGSVSLKHSLSLLDLEQKLKEIRNLVEQHKSSSWIN 226
            :.:|..:|:....|:.||:..:.:|:...|      .:..|.|::.| .|:|:..:  :.|..|:
 Worm   191 RIFLQCVQYFTLRGIPELMEYVAEAIPNEL------QNWKLTDIKSK-TEMRDFFD--RVSYRIS 246

Human   227 KDGSKPLLCHYMMPDEETPLAVQACGLSPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRL 291
            .:|   ||...:.|       :...| .....:.:|||.:....|||.....|||:.|:..||..
 Worm   247 FNG---LLTKLVAP-------LDGDG-QDNSSSVMKLLQKLTTNLESSKSIHVLNSLLDFYFSAA 300

Human   292 LDNMAEFFRPTEQDLQHGNSMNSLSSVSLPLAKIIPIVNGQIHSVCSETPSHFVQDLLTMEQVKD 356
            |       :..|.|.|             ||.|.:|..:.....:.|......:.:.|....:..
 Worm   301 L-------KMVENDEQ-------------PLVKYVPAFSNSFPILTSTAFDSPLFNSLYSSDIHQ 345

Human   357 FAANVYEA 364
            ||..|:.:
 Worm   346 FAVYVFNS 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX3	NP_003621.1	Targeting to peroxisomes. /evidence=ECO:0000269|PubMed:11390669	1..45		14/45 (31%)
		Peroxin-3	11..362	CDD:428171	87/384 (23%)
		Interaction with PEX19. /evidence=ECO:0000269|PubMed:11390669	120..136		3/15 (20%)
prx-3	NP_001123111.1	None