Protein Alignment ARHGAP19 and RhoGAP54D

DIOPT Version :10

• Sequence 1: NP_116289.4
• Gene: ARHGAP19 / 84986
• HGNCID: 23724
• Length: 494
• Species: Homo sapiens
• Sequence 2: NP_611236.2
• Gene: RhoGAP54D / 36996
• FlyBaseID: FBgn0034249
• Length: 1004
• Species: Drosophila melanogaster
• Alignment Length: 377
• Identity: 118/377 - (31%)
• Similarity: 193/377 - (51%)
• Gaps: 34/377 - (9%)

Human   122 IAQIYQLIEY--LHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFL 184
            :..:.:|.|:  |.|||..|||||..|...||..||..:.:...::||...|.::|.||:.|.||
  Fly   113 LMHLQELKEFLMLEKNLTQEGLFRKAGAVSRQNELRMHIQHDKPLNLELAGFSAHDCATVFKGFL 177

Human   185 GELPEPLLTHKHFNAHLKIADLMQFDDKGNKTNIPDKDRQ-IEALQLLFLILPPPNRNLLKLLLD 248
            .||||||||..|:.|||:||.|.|..: |..|...::.:. :.::|||.|:||..:|.||:.:::
  Fly   178 SELPEPLLTDAHYPAHLQIAPLCQALN-GQTTATAERQQHLLNSVQLLLLLLPEEHRELLQHIIE 241

Human   249 LLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAY 313
            :|:..||.:..|||||.|||.:|.||::.|:.:....|.....|::|.:.:||.....:|:.|..
  Fly   242 MLHAVAKHEKSNKMSADNLATLFTPHLICPRQLPPEVLHYQAKKMSSIVTYMIVRGLDIFEVPGK 306

Human   314 IRECARLHYLGSRTQ----------ASKDDLDLIASCHTKSFQLAKSQKRNRVDSCPHQEETQHH 368
            :....|.::|..:.:          .|..|:..:.:.:|...:.|.:...|           .::
  Fly   307 LSTDIRAYFLERKRKKTMSPEQTLDESISDVSTVNTVYTFVDRAATAAATN-----------TNN 360

Human   369 TEEALRELFQHVHDMPESAKKKQLIRQFNKQSLTQTPGREPSTSQVQKRARSRSFSGL---IKRK 430
            |:..|.:|:.|:..||||:||::||:|||||:...||.:....::::....:||...|   ||:.
  Fly   361 TDTELAQLYAHIQSMPESSKKRRLIKQFNKQNGQGTPLQLVVMNRLKNNEATRSAKSLGDSIKKH 425

Human   431 VLGNQMMSEKKKKNPTPESVAIG----ELKGTSKENRNLLFSGSPAVTMTPT 478
            :....:||...|:.|....:|.|    .:.........:||. || ...|||
  Fly   426 IFHKSLMSRTPKRVPPSFHLASGSETPNMSHVKPPKMRVLFQ-SP-TPPTPT 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP19	NP_116289.4	RhoGAP_ARHGAP19	113..320	CDD:239857	74/200 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..368		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..421		3/21 (14%)
RhoGAP54D	NP_611236.2	RhoGAP	107..313	CDD:470621	74/200 (37%)