Protein Alignment ARHGAP19 and arhgap19

DIOPT Version :10

• Sequence 1: NP_116289.4
• Gene: ARHGAP19 / 84986
• HGNCID: 23724
• Length: 494
• Species: Homo sapiens
• Sequence 2: XP_003201186.1
• Gene: arhgap19 / 100537002
• ZFINID: ZDB-GENE-100922-157
• Length: 454
• Species: Danio rerio
• Alignment Length: 470
• Identity: 285/470 - (60%)
• Similarity: 346/470 - (73%)
• Gaps: 31/470 - (6%)

Human     1 MATEAQSEGEVPARESGRSDAICSFVICNDSSLRGQ------PIIFNPDFFVEKLRHEKPEIFTE 59
            ||||..::    ..:..|...:|:.|| |..|..|.      ||||||||||||:|||:||.|||
Zfish     1 MATEKDTD----VNKRDRRGTVCNVVI-NQESETGSSGEGRPPIIFNPDFFVEKMRHERPEAFTE 60

Human    60 LVVSNITRLIDLPGTELAQLMGEVDLKLPGGAGPASGFFRSLMSLKRKEKGVIFGSPLTEEGIAQ 124
            ||:|||||||||||.|.:||:|:.:.|.|.     :|||||...||||:|||:||.|||||||||
Zfish    61 LVLSNITRLIDLPGAEFSQLLGDEEPKTPN-----AGFFRSFNFLKRKDKGVVFGMPLTEEGIAQ 120

Human   125 IYQLIEYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPE 189
            |||||.||.|||.|:|||||||||:|||.||:.||:|.|||..:|:||.||||||||.|||||||
Zfish   121 IYQLIAYLSKNLHVQGLFRVPGNSLRQQTLREQLNSGADIDFAAGDFHPNDVATLLKSFLGELPE 185

Human   190 PLLTHKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTA 254
            |||||:|.:|||||.:|..|||:||||:.|||:|||||||||.|:||..||.||||||||||.||
Zfish   186 PLLTHRHLHAHLKITELTTFDDEGNKTSFPDKERQIEALQLLLLLLPTANRTLLKLLLDLLYHTA 250

Human   255 KKQDKNKMSAYNLALMFAPHVLWPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAYIRECAR 319
            |:||||||||:||||||.|||:||||:.|:|||||:.||||||||:||||||:|:||||:||.||
Zfish   251 KQQDKNKMSAHNLALMFGPHVIWPKNMNASDLQENLKKLNSGMAFLIKHSQKIFRAPAYLREHAR 315

Human   320 LHYLGSRTQASKDDLDLIASCHTKSFQLAK-SQKRNRVDSCPHQEETQHHTEEALRELFQHVHD- 382
            |.:..::...|||||:|::...:......| |.:|.|:||       .:||||||:||::||.|
Zfish   316 LQFANTKILQSKDDLELLSVSGSPFISACKRSGERVRLDS-------DNHTEEALKELYRHVTDN 373

Human   383 MPESAKKKQLIRQFNKQSLTQTPGREPSTSQVQKRARSRSFSGLIKRKVLGNQMMSEKKKKNPTP 447
            ||.|||||:||||..|.|...||..|..|...:|..|||||.|||||||||.| .::::.::.:|
Zfish   374 MPNSAKKKKLIRQLGKPSTPGTPVNENLTPSSKKHGRSRSFGGLIKRKVLGGQ-PADRRGRHVSP 437

Human   448 ESVAIGELKGTSKEN 462
            :|.|     |..|||
Zfish   438 QSAA-----GLGKEN 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP19	NP_116289.4	RhoGAP_ARHGAP19	113..320	CDD:239857	158/206 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..368		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..421		7/21 (33%)
arhgap19	XP_003201186.1	RhoGAP_ARHGAP19	109..316	CDD:239857	158/206 (77%)