Protein Alignment FRMD5 and frmd5a

DIOPT Version :10

• Sequence 1: NP_116281.2
• Gene: FRMD5 / 84978
• HGNCID: 28214
• Length: 570
• Species: Homo sapiens
• Sequence 2: XP_699526.3
• Gene: frmd5a / 570903
• ZFINID: ZDB-GENE-050419-226
• Length: 576
• Species: Danio rerio
• Alignment Length: 575
• Identity: 494/575 - (85%)
• Similarity: 527/575 - (91%)
• Gaps: 7/575 - (1%)

Human     1 MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDP 65
            |||||||||.|:|||||.||||||||:||||||||||||||||||:|||||||||||||||:|||
Zfish     2 MLSRLMSGSVRNLEREYMCTVRLLDDTEYTCTIQRDAKGQYLFDLICHHLNLLEKDYFGIRYVDP 66

Human    66 DKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKT 130
            ||||||||||||:.||::||||||||.||||||.|||||||||||||||||||||||||||||||
Zfish    67 DKQRHWLEFTKSISKQMKSQPPFTMCLRVKFYPPDPAALKEEITRYLVFLQIKRDLYHGRLLCKT 131

Human   131 SDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNF 195
            ||||:||||||||||||||.|||||||||||||||||||||||:|||||||||.||||.||||.|
Zfish   132 SDAAMLAAYILQAEIGDYDPGKHPEGYSSKFQFFPKHSEKLERRIAEIHKTELIGQTPETSELKF 196

Human   196 LRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYV 260
            |:|||.|||||||||||||||||.|||||||||||||||||||||:|||||||||||||||::|.
Zfish   197 LQKAQMLETYGVDPHPCKDVSGNPAFLAFTPFGFVVLQGNKRVHFLKWNEVTKLKFEGKTFHIYA 261

Human   261 SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAK 325
            :|||:||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
Zfish   262 NQKEDKKIILTYFAPTPEACKHLWKCGVENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAK 326

Human   326 EVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHST 390
            ||||.|||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
Zfish   327 EVMEQSAKIKREPPEIHRAGLVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHST 391

Human   391 PVRSTSHGDTFLPHVRSSRTDSNERVAVIADEAYSPADSVLPTPVAEHSLELMLLSRQINGATCS 455
            ||||.||||:|:|..||..|||.:|.|:|:||:|||:||||||||||||||| .:|||||||.||
Zfish   392 PVRSVSHGDSFMPRSRSQMTDSGDRTAIISDESYSPSDSVLPTPVAEHSLEL-AVSRQINGAPCS 455

Human   456 IEEEKESEASTPTATEVEALGGELRAL----CQGHSGP--EEEQVNKFVLSVLRLLLVTMGLLFV 514
            |||||||||.||:..:|...|.:.||.    ..|...|  |.|||||||||||||||||:|||||
Zfish   456 IEEEKESEAGTPSVGDVAEFGADSRAAGPMQIAGREAPLSEAEQVNKFVLSVLRLLLVTIGLLFV 520

Human   515 LLLLLIILTESDLDIAFFRDIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSLLID 569
            ||||||:||||||||||.||||||||||||||:||||||||||||:|.|..|||:
Zfish   521 LLLLLIVLTESDLDIAFLRDIRQTPEFEQFHYEYFCPLRRWFACKLRWVGGLLIN 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD5	NP_116281.2	B41	19..210	CDD:214604	173/190 (91%)
		FERM_C_FRMD3_FRMD5	191..295	CDD:270013	92/103 (89%)
		Interaction with ROCK1. /evidence=ECO:0000269|PubMed:25448675	308..353		42/44 (95%)
		FA	309..354	CDD:462582	42/44 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..367		21/22 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..407		16/21 (76%)
frmd5a	XP_699526.3	B41	19..211	CDD:214604	173/191 (91%)
		PH-like	192..296	CDD:473070	92/103 (89%)
		FA	310..355	CDD:462582	42/44 (95%)