Protein Alignment FRMD5 and Frmd5

DIOPT Version :10

• Sequence 1: NP_116281.2
• Gene: FRMD5 / 84978
• HGNCID: 28214
• Length: 570
• Species: Homo sapiens
• Sequence 2: NP_609384.1
• Gene: Frmd5 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 190/583 - (32%)
• Similarity: 275/583 - (47%)
• Gaps: 66/583 - (11%)

Human    17 YSCTVRLLDDSE-YTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVK 80
            |.|||||||||: ..|..|...||.||.:.||..|.:.||||||:|:||..||||||:.:||::|
  Fly    12 YKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIK 76

Human    81 QLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEI 145
            |.:...|.....|||||||||..|... .|.:::.|:||||.||||.|...:||.|.|.|:|.|:
  Fly    77 QCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEEL 140

Human   146 GDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPH 210
            |||:...|...|.|..:...:.:|.||:||.|:||....||..:.:...||..|:.|||||:|||
  Fly   141 GDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDPH 205

Human   211 PCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYVS----QKEEKKIILT 271
            |.||..|:..::.....|.......||....:|||:.|:.||||.|..::|    .:|.||..:.
  Fly   206 PVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKHTVG 270

Human   272 YFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKR 336
            :..||..||::||:|.||...|:.|..|.....:|....|..|::|||:||..:|::..:....|
  Fly   271 FKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREILTENINALR 335

Human   337 EPPEIHRAGMVPSRSCPSITHGP-------RLSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRS 394
            |......:....:.|.|:....|       |.||:||:   .:...:..|:.:.....|...:..
  Fly   336 EQKNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRS---TMSEPLGYGMPNGHFYGHDHGMSD 397

Human   395 TSHG---DTFLP-----HVRSSRTDSNERVAVIADE--AYSPADSVLPTPVAEHSLELMLLSRQI 449
            .:.|   .:..|     .:|||..|.   |..:|.:  .|:..|||      |||.....|:  :
  Fly   398 ANGGIQISSLEPVCEEARLRSSNIDG---VNYLASQIGGYAYRDSV------EHSSTESGLT--V 451

Human   450 NGATCSIEEEKESEASTPTATEVEALGGELRALCQG--------HSGPEEEQVNK---------F 497
            ||..   ...|.:||....:.......|:.......        |:.|...:|.|         |
  Fly   452 NGYD---HPRKHNEARQHGSYSPNLYYGQSDGAVNSSSPADSFLHADPSTRKVKKFRKFHLLHAF 513

Human   498 VLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFRDIRQTPEFEQFHYQYFCPLRRWFACKI 560
            |.||:.:.....|       ..:.:.||:.:.  |..:|.:||.....|||:.||:.:...|:
  Fly   514 VPSVIFVAFAMAG-------TAVFIMESESEA--FEQLRNSPEMLCLRYQYYQPLKEFVLEKL 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD5	NP_116281.2	B41	19..210	CDD:214604	91/191 (48%)
		FERM_C_FRMD3_FRMD5	191..295	CDD:270013	41/107 (38%)
		Interaction with ROCK1. /evidence=ECO:0000269|PubMed:25448675	308..353		11/44 (25%)
		FA	309..354	CDD:462582	11/44 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..367		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..407		3/29 (10%)
Frmd5	NP_609384.1	FERM_F1_FRMD3	12..93	CDD:340622	42/80 (53%)
		FERM_M	104..205	CDD:459788	43/100 (43%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	41/107 (38%)
		FA	308..350	CDD:462582	10/41 (24%)