Protein Alignment FRMD5 and Frmd5

DIOPT Version :10

• Sequence 1: NP_116281.2
• Gene: FRMD5 / 84978
• HGNCID: 28214
• Length: 570
• Species: Homo sapiens
• Sequence 2: XP_011237768.1
• Gene: Frmd5 / 228564
• MGIID: 2442557
• Length: 599
• Species: Mus musculus
• Alignment Length: 599
• Identity: 561/599 - (93%)
• Similarity: 565/599 - (94%)
• Gaps: 29/599 - (4%)

Human     1 MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDP 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDP 65

Human    66 DKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKT 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 DKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKT 130

Human   131 SDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNF 195
            |||||||||||||||||||.||||||||||||||||||||||:||||||||||||||||||||||
Mouse   131 SDAALLAAYILQAEIGDYDPGKHPEGYSSKFQFFPKHSEKLEKKIAEIHKTELSGQTPATSELNF 195

Human   196 LRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIK------------------ 242
            |||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 LRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKCILFASFTAAIHWAGGFK 260

Human   243 -----------WNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKL 296
                       ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 DFSTITPKPLSWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKL 325

Human   297 EKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRL 361
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 EKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRL 390

Human   362 SSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERVAVIADEAYSP 426
            |||||||||||||||||||||||||||||||||:||||||||||||||.||||||||||||||||
Mouse   391 SSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSSSHGDTFLPHVRSSRADSNERVAVIADEAYSP 455

Human   427 ADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELRALCQGHSGPEE 491
            |||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||.|.|:
Mouse   456 ADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEAEALGGELRALCQGHGGSEQ 520

Human   492 EQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFRDIRQTPEFEQFHYQYFCPLRRWF 556
            |||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||
Mouse   521 EQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDVAFFRDIRQTPEFEQFHYQYFCPLRRWF 585

Human   557 ACKIRSVVSLLIDT 570
            ||||||||||||||
Mouse   586 ACKIRSVVSLLIDT 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD5	NP_116281.2	B41	19..210	CDD:214604	188/190 (99%)
		FERM_C_FRMD3_FRMD5	191..295	CDD:270013	103/132 (78%)
		Interaction with ROCK1. /evidence=ECO:0000269|PubMed:25448675	308..353		44/44 (100%)
		FA	309..354	CDD:462582	44/44 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..367		22/22 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..407		20/21 (95%)
Frmd5	XP_011237768.1	B41	19..210	CDD:214604	188/190 (99%)
		PH-like	191..324	CDD:473070	103/132 (78%)
		FA	338..383	CDD:462582	44/44 (100%)