Protein Alignment FRMD5 and frm-4

DIOPT Version :10

• Sequence 1: NP_116281.2
• Gene: FRMD5 / 84978
• HGNCID: 28214
• Length: 570
• Species: Homo sapiens
• Sequence 2: NP_001249887.1
• Gene: frm-4 / 172189
• WormBaseID: WBGene00001491
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 693
• Identity: 179/693 - (25%)
• Similarity: 292/693 - (42%)
• Gaps: 165/693 - (23%)

Human     2 LSRLMSGSSRSL--EREYSCTVRLLDDSEYTCT-IQRDAKGQYLFDLLCHHLNLLEKDYFGIRFV 63
            |.||.:.:..|.  .::..|.|.||.||:.... ..|....|.:.|.:|...::.|||:.|:|:.
 Worm    11 LGRLTTSTRSSFMSPKDVRCNVHLLHDSDIIGNEFPRTQSAQTILDYVCQLKHIQEKDFLGLRYQ 75

Human    64 DPDKQRHWLEFTKSV----------VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIK 118
            |..|.|:||:.|:|:          :|::......|:..|.::||:|||.|::...||.:|:|::
 Worm    76 DHHKHRYWLDLTRSINHVVKNFKKEIKKVGKTESMTLHLRFRYYPSDPARLRDPNLRYQLFVQLQ 140

Human   119 RDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTEL 183
            |||.||||.|.||.||.|||.||||::|||:..||...|.|.::...|.:.|||.:||..|| ||
 Worm   141 RDLLHGRLYCPTSSAAELAALILQAQLGDYNEEKHVGNYVSGYKLLLKQTPKLEERIANNHK-EL 204

Human   184 SGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGN-AAFLAFTPFGFVVLQGNKRVHFIKWNEVT 247
            .|::..::||.||.||..|:||..||:..|:.... ..::..:..|.::..|..|.|.|.|:|:.
 Worm   205 KGKSSESAELEFLEKASQLDTYAFDPYTIKEPHDTLPVYIGASCKGILIYTGQSRTHNIDWSELV 269

Human   248 KLKFEGKTFYLYVSQK------------------------------EEKKIILTYFAPTPEACKH 282
            |:.:.||...|.:|:.                              .:|.:.|.|..|:.:..||
 Worm   270 KVDYSGKEIRLTLSENYRGQITAAGTPTGTLNGHGPGSPSIMDKSLTKKPLTLKYTCPSGQFAKH 334

Human   283 LWKCGIENQAFYKLEKSSQVRTVSSS---NLFFKGSRFRY-SGRVAKEVMESSAKIKREPPEIHR 343
            ||...:..|||:....:..|:...|.   .|..:||.||: |.||.:|:.|..:|.......|..
 Worm   335 LWIHILSQQAFFNETSAQDVKLKFSKPRIPLLSRGSTFRFPSKRVYREIEEEDSKSILFDKSIME 399

Human   344 AGMVPSR------------SCPSIT----------------HGPRLSSVPRTRRRAVHISIMEGL 380
            ...|.:.            :|.:|:                ..||:.. |..::.::.::
 Worm   400 TSAVMNETTTSNENEESILNCSTISAPLSSGSGVVRYDLLRQTPRVEQ-PWLKQNSLKVT----- 458

Human   381 ESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNE-------RVAVIADEAYSPADSVLPTPV--- 435
                 :.|.....|:|..|       :|.|.:|.       .:::..:.:.||:.|  |.|:
 Worm   459 -----TVHDNTASSSSSPD-------NSETQNNNLSKITNLNLSIEREVSTSPSTS--PVPIVHT 509

Human   436 ---AEH---SLELMLLSRQINGATCSIEEEKESEASTPTATEVEAL--GGELRALCQGHSG---- 488
               ::|   |..:.|:.|:      .:.....|.:||.|..:.:.|  .|..:....|.||
 Worm   510 QQHSDHNSTSFTVHLIKRE------EVATSSSSTSSTTTTGQQQNLEKNGNGKLANGGGSGVDLG 568

Human   489 -------------PEEEQVNKFVL-------SVLRLLLVTMGLLFVLLLLL----IILTESDLDI 529
                         .||:|.:...:       |::..:..|..:.|::|||:    |:|.|...|.
 Worm   569 KKTVHTNGTTLICTEEKQDSILSMDESLTSKSLISRIANTCFVFFLILLLIVAIVIVLFEKSEDS 633

Human   530 A---FFRDIRQTPEFEQFHY---------QYFCPLRRWFACKI 560
            |   |....|...:....:|         ||    |:.|..||
 Worm   634 AHNDFIESHRALSDLRHLYYEPTRHYVVEQY----RKHFGAKI 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD5	NP_116281.2	B41	19..210	CDD:214604	82/201 (41%)
		FERM_C_FRMD3_FRMD5	191..295	CDD:270013	35/134 (26%)
		Interaction with ROCK1. /evidence=ECO:0000269|PubMed:25448675	308..353		13/60 (22%)
		FA	309..354	CDD:462582	14/57 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..367		6/50 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..407		4/21 (19%)
frm-4	NP_001249887.1	B41	29..226	CDD:214604	79/197 (40%)
		PH-like	212..346	CDD:473070	34/133 (26%)