Protein Alignment PPFIBP2 and Liprin-gamma

DIOPT Version :10

• Sequence 1: NP_001338782.2
• Gene: PPFIBP2 / 8495
• HGNCID: 9250
• Length: 928
• Species: Homo sapiens
• Sequence 2: NP_001097414.1
• Gene: Liprin-gamma / 37552
• FlyBaseID: FBgn0034720
• Length: 1152
• Species: Drosophila melanogaster
• Alignment Length: 1032
• Identity: 273/1032 - (26%)
• Similarity: 398/1032 - (38%)
• Gaps: 278/1032 - (26%)

Human     5 ASHALEAALEQMDGIIAGT------KTGADLSDGTCEPGLASPASYMNPFPVLHLIEDLRLALEM 63
            |.|..:||....:...:|:      |..|:||:         |...:.|...::|..:..|||..
  Fly   209 AGHLAQAAGPAHNAPSSGSALNAVDKRNANLSE---------PDQDLPPNLNVNLSPNPSLALGA 264

Human    64 LELPQERAA----LLSQIPGPTAAYIKEWFEESLSQVNH-HSAASNET---YQERLARLEGDKES 120
            ...|...|:    ||....|.         ....|:.:| |||...|.   .:|...||..:...
  Fly   265 PHSPTSAASAALLLLESCDGN---------RNDESRFHHLHSAPRPEATMKLREENDRLNAELLR 320

Human   121 LILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQEL-----------LSRTSLETQK 174
            |...:.:.||......:...::|....|.........|.|:.||           |.|..|.|.|
  Fly   321 LRRLLELSTDGAVGGVDTAPEMEAVASGEGSAAKERIERLESELRSVKNQLLTMRLERKKLRTDK 385

Human   175 LDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVE-ELENERNQYEWKLKATKA 238
            .||:.:|.:|...|  .|||| |..:..|..:|.::|......|:. :.:.||.|.   ||..:.
  Fly   386 SDLLGQVKQLCASL--QEKEQ-ELRDFIRNYQERVRETETTNAKISGDRDRERFQL---LKQARD 444

Human   239 EVAQ---LQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRI 300
            |..:   |.:|::.:|.:::||..||               ||.:|
  Fly   445 EAERSLALAQQLSARDLQLQRLQEQL---------------QEARR------------------- 475

Human   301 EELTGLLNQYRKVKEIVMVTQGPSERTLSINEEEPE----GGFSKWNATNKDPEELFKQEMPPRC 361
             :|||.|:....:.....:|. ||..:..:::....    ||.:....|.:|         ..|.
  Fly   476 -QLTGCLSDQESLHSFAPLTP-PSAASGMLSQMAAASGMGGGLAGMRGTTED---------SGRG 529

Human   362 SSPTVGPPPLPQKSLETRAQKKLSCSLED-LRSESVDKCMDG----------NQPFPVLEPKDSP 415
            :|.:.....|...|..|...:. |||.:. ||:.|..:...|          |.|...::| ||.
  Fly   530 NSLSAFSGSLSGGSGATAGDRN-SCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVDP-DSI 592

Human   416 FLA-----------EHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLNRGRSV---SA 466
            .|.           :.:.|||       :|...||.|                    |||   .:
  Fly   593 SLVSSQNMYQFGTPKERSPTL-------SPLNSAAYS--------------------RSVEQLGS 630

Human   467 PVLGDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFWGKIRR----------- 520
            ||  |.| |..:.|:....::.|   :|||.      |.||.:|  ..||.|.|
  Fly   631 PV--DPE-GPGNGAISRKFANAS---KSGPL------GARNGRG--GTWGSISRVFARSRNKNKA 681

Human   521 ------TQSGNFYTDTL---GMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCA 576
                  |:..::..:.|   |.||            :|...|::      :..|..:|...:|.|
  Fly   682 LSADGVTEYADYSWNPLTEEGYAE------------KLRLLREA------SQLPIDRWRATQVLA 728

Human   577 WLE-DFGLAQYVIFARQWVSSGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSAL 640
            ||| ..|:.||.....:.|.||..||.....::|..||:.||:|||||.||::.....:..:..|
  Fly   729 WLEVALGMPQYSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEEQRRPEMVRYPL 793

Human   641 ---LDHIWV-TRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDL-LFLKVTSQLHHLSIKCAIHV 700
               |.|.|| |.||.|||||||.:.|.:|.||.|||..|:..:| .||.||.:.|..||...|||
  Fly   794 ITQLGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHV 858

Human   701 LHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPR 765
            |.:.|::...|..|......:....:| |:|.|.:.|:||:||.|||.||:.|||||||::|||.
  Fly   859 LRIVKYDRQTLAMRRVQSETVDTDPIV-WTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPS 922

Human   766 FTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFS 830
            |:|||:|..|.|||.|.::||||.|:|:|||.|......:...:.....|||...       |..
  Fly   923 FSGDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLTGPG-------GLQ 980

Human   831 HF--------GNIR--------------------------KKKFDESTDYICPMEPSDGVSDSH- 860
            |:        ||:|                          :..|..||      .|:...|.|.
  Fly   981 HYATTDRRSSGNLRISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNST------SPTPSYSSSEG 1039

Human   861 --RVYS--GYRGLSPLDAPELDGLDQHQWKHMNFDAGPETMDTPT----RLSSQAPP 909
              .:|:  |::..:|     ...|.|..:.|  |...|.|...|.    .:.|..||
  Fly  1040 GGGIYATIGHQYPNP-----HTNLQQQHYHH--FLPPPTTAPPPIPSAGGIYSHGPP 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPFIBP2	NP_001338782.2	SMC_prok_B	59..>317	CDD:274008	65/280 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..376		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..451		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..511		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..564		2/25 (8%)
		SAM_liprin-beta1,2_repeat1	566..629	CDD:188962	26/63 (41%)
		SAM_liprin-beta1,2_repeat2	640..702	CDD:188965	34/66 (52%)
		SAM_liprin-beta1,2_repeat3	725..796	CDD:188968	41/70 (59%)
Liprin-gamma	NP_001097414.1	COG4372	<346..>460	CDD:443500	32/119 (27%)
		SAM_kazrin_repeat1	718..787	CDD:188963	26/68 (38%)
		SAM_kazrin_repeat2	796..860	CDD:188966	33/63 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	41/71 (58%)