Protein Alignment PPM1D and Pp2C1

DIOPT Version :9

• Sequence 1: NP_003611.1
• Gene: PPM1D / 8493
• HGNCID: 9277
• Length: 605
• Species: Homo sapiens
• Sequence 2: NP_001284867.1
• Gene: Pp2C1 / 31404
• FlyBaseID: FBgn0022768
• Length: 1427
• Species: Drosophila melanogaster
• Alignment Length: 630
• Identity: 197/630 - (31%)
• Similarity: 291/630 - (46%)
• Gaps: 152/630 - (24%)

Human     6 SLGVSVFSD----QGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGK 66
            ||||::...    |||||||||...:..:..|...|
  Fly   251 SLGVNMRVTGQCCQGGRKYMEDQFSVAYQESPITHE----------------------------- 286

Human    67 GPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFT 131
                                         ...|||.:.|||||.|||.||:|||...|.|||.|.
  Fly   287 -----------------------------LEYAFFGIYDGHGGPEAALFAKEHLMLEIVKQKQFW 322

Human   132 SSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVV 196
            |.:...|..|||:|::|.|.|||::..:||:|..|..||:||||:|..:|..|:|:.||||||:|
  Fly   323 SDQDEDVLRAIREGYIATHFAMWREQEKWPRTANGHLSTAGTTATVAFMRREKIYIGHVGDSGIV 387

Human   197 LGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPR-LTHNGPVRRS 260
            ||.|:..:.:: ||..:|.|||||...|:.||:..||:|..||||.||||.||| ..|.||:||.
  Fly   388 LGYQNKGERNW-RARPLTTDHKPESLAEKTRIQRSGGNVAIKSGVPRVVWNRPRDPMHRGPIRRR 451

Human   261 TVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDA 325
            |::|:||||||||:|||||||:....||||||:||..|..::|...:.:|.|:|||||::..|:|
  Fly   452 TLVDEIPFLAVARSLGDLWSYNSRFKEFVVSPDPDVKVVKINPSTFRCLIFGTDGLWNVVTAQEA 516

Human   326 ISMCQDQEEKKYLMGE-----HGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNF 385
            :    |...|::|:||     ...:.:|.||::||..|..:.:||||||.:.:.::|...|....
  Fly   517 V----DSVRKEHLIGEILNEQDVMNPSKALVDQALKTWAAKKMRADNTSVVTVILTPAARNNSPT 577

Human   386 TNEDELYLNLTDSPSY----NSQETCVMTPSPCSTPPVKSLE---------------EDPWPRVN 431
            |.        |.|||.    |..|..::........|...:|               :.|:..:.
  Fly   578 TP--------TRSPSAMARDNDLEVELLLEEDDEELPTLDVENNYPDFLIEEHEYVLDQPYSALA 634

Human   432 SKDHIPALVRSNAF---SENFLEVSAEIARENVQ------------------------------- 462
            .:...|...|:..:   .|:.|:...|...|:.:
  Fly   635 KRHSPPEAFRNFDYFDVDEDELDEDEETVEEDEEEEEEEEETKSVGILQQSLFNPRKTWRKSTIN 699

Human   463 ----GVVIPSKDPEPLEENCAKALTLRI--HDSLNNSLPI-GLVPTNSTNTVMDQKNLKMSTPGQ 520
                ||..|..:|:| |.:....|||.:  |.|::..... |.:..:|.:.....:|.::|
  Fly   700 NSWSGVTEPEPEPDP-EPDRIDVLTLDMYSHTSIDKGTNYGGSIAQSSIDPAETAENRELS---- 759

Human   521 MKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPAS 565
                |:|:...:::  :..||.:..|.::..:...|||:.|..|:
  Fly   760 ----ELEQHLESSY--SFAESYNSLLNEQEEQEARSRSAAAAAAA 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPM1D	NP_003611.1	Interaction with CHEK1. /evidence=ECO:0000269|PubMed:15870257	1..101		16/98 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..90		2/61 (3%)
		PP2C	67..368	CDD:278884	136/306 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	516..591		11/50 (22%)
Pp2C1	NP_001284867.1	PP2Cc	256..567	CDD:238083	150/373 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158666
Domainoid	1	1.000	260	1.000	Domainoid score	I1989
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3901
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006472
OrthoInspector	1	1.000	-	-		oto91838
orthoMCL	1	0.900	-	-		OOG6_106734
Panther	1	1.100	-	-	LDO	PTHR47992
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4185
SonicParanoid	1	1.000	-	-		X4721
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.680