DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PRSS12 and Loxl2

DIOPT Version :9

Sequence 1:NP_003610.2 Gene:PRSS12 / 8492 HGNCID:9477 Length:875 Species:Homo sapiens
Sequence 2:NP_523806.2 Gene:Loxl2 / 37485 FlyBaseID:FBgn0034660 Length:511 Species:Drosophila melanogaster


Alignment Length:448 Identity:120/448 - (26%)
Similarity:176/448 - (39%) Gaps:124/448 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   384 DGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGP- 447
            :|.|||.||...:||.:||.:.|:||.||||.|......:|||||||...::.:.:.|   .|| 
  Fly    58 EGAIRLVGGDNEYEGNIEVLHNGKWGAVCDDEWDSTEADIVCRQLGFPGMRRYTRSGF---FGPA 119

Human   448 ---IWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFP---------- 499
               .|:|::.|.|.|...:.|....||.:||...|...:.||| .|...:.:..|          
  Fly   120 RRRFWMDNLFCEGHEQELVDCHFEGWGENDCEPGEAAGVVCYP-PENALIPMATPIIRDEDLPKY 183

Human   500 ---------VRLMDGENKKEGRVEVFIN-GQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAY 554
                     |||..|.::.||||||.:: |:||::|.|||:..:|.|:|||||....:.|....:
  Fly   184 PIHSRSRLYVRLRGGRSRIEGRVEVSLDGGRWGSVCADGWSLLEANVVCRQLGLGYASEAFQTDF 248

Human   555 FG--EGKGPIHVDNVKCTGNERSLADCIKQDI--GRHNCRHSED--AGVICDYFG---------- 603
            ||  ....|: :...:|.|||..||||:..|.  |..:|..:..  |.|||||..          
  Fly   249 FGGFNVSRPV-LSGSECYGNETELADCLHHDASQGIISCHGNRQHVAAVICDYIAPDLVVDYLEI 312

Human   604 KKASGNSNKESLSSVCGL------------------------RLLHRRQKRIIGGKNSLR----- 639
            ::.:...::..|...|.:                        |||......|..|....|     
  Fly   313 EQTAHLEDRPMLLMQCAMEENCVANEAYQIQRDDPHWRYRSRRLLKFTAAAINAGNADFRPFKEK 377

Human   640 GGWPWQV-----------------SLR-LKSSHG--------DGRLLCGATLLSSCWVLTAAHCF 678
            ..|.|.:                 :|| :|.:.|        |...|.|.....:|         
  Fly   378 SQWEWHMCHMHFHSMEVFATFDIFNLRGIKVAQGHKASFCLEDSNCLPGVAKKYNC--------- 433

Human   679 KRYG------NSTRSYAVRVG----DYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYD 726
            ..||      |.:..|...:.    |...|:|..:     |.:|.|:.|::....:||
  Fly   434 ANYGDQGISINCSDVYLYNLDCQWVDVTDLIPGTY-----VLKIAINPEFKVAEMNYD 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRSS12NP_003610.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..88
KR 99..164 CDD:214527
SR 170..270 CDD:214555
SRCR 175..270 CDD:278931
SR 280..380 CDD:214555
SRCR 285..380 CDD:278931
SR 387..486 CDD:214555 38/102 (37%)
SRCR 392..485 CDD:278931 34/96 (35%)
SR 500..599 CDD:214555 41/105 (39%)
SRCR 510..599 CDD:278931 37/95 (39%)
Zymogen activation region 619..630 4/34 (12%)
Tryp_SPc 630..869 CDD:214473 26/138 (19%)
Tryp_SPc 631..872 CDD:238113 26/137 (19%)
Loxl2NP_523806.2 SR 61..161 CDD:214555 38/102 (37%)
SRCR 66..160 CDD:278931 34/96 (35%)
SR 193..298 CDD:214555 41/105 (39%)
SRCR 198..298 CDD:278931 38/100 (38%)
Lysyl_oxidase 303..503 CDD:279521 31/198 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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