DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF587 and LOC100488006

DIOPT Version :9

Sequence 1:	NP_116217.1	Gene:	ZNF587 / 84914	HGNCID:	30955	Length:	575	Species:	Homo sapiens
Sequence 2:	XP_002937452.2	Gene:	LOC100488006 / 100488006	-ID:	-	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	337	Identity:	142/337 - (42%)
Similarity:	186/337 - (55%)	Gaps:	48/337 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   176 GKDVLPSSGLCQEEAAVE----------------KTDSETMH--------GPPFQEGKTNYSCGK 216
            |.:::.:.|..|:||.::                |...|.:|        .....|.|.::...|
Frog    56 GANLMVAGGFDQQEAEIKEYFIENPGNRAKFRINKATWENIHKGSESSENSLDESESKMDFGVQK 120

Human   217 RTKAFSTKHSVIPHQKLFTRDGCYVCSDCGKSFSRYVS-FSNHQRDHTAKGPYDCGECGKSYSRK 280
            |                     | ||.|||:||| ||| ...|:|.||.:.|::||.|||.::||
Frog   121 R---------------------C-VCIDCGRSFS-YVSHLIIHRRSHTGEKPFECGMCGKCFARK 162

Human   281 SSLIQHQRVHTGQTAYPCEECGKSFSQKGSLISHQLVHTGEGPYECRECGKSFGQKGNLIQHQQG 345
            .||:.|:|:|||:..|||.:|||.|:...:|.:|:.:||||.||.|.||||||....:|..|.:.
Frog   163 CSLVIHERIHTGERPYPCPDCGKRFTSSATLTTHKRIHTGERPYICWECGKSFTSNSSLFLHNRT 227

Human   346 HTGERAYHCGECGKSFRQKFCFINHQRVHTGERPYKCGECGKSFGQKGNLVHHQRGHTGERPYEC 410
            ||||:.|.|.:|||:|......:.|.|.||||:||.|.||||||.....|:.||..||||..|.|
Frog   228 HTGEKPYECKQCGKTFSCSSALVTHTRTHTGEKPYTCAECGKSFFDNSRLLKHQATHTGEWAYMC 292

Human   411 KECGKSFRYRSHLTEHQRLHTGERPYNCRECGKLFNRKYHLLVHERVHTGERPYACEVCGKLFGN 475
            ..|||.|...|:|..|||.||||||::|.:|||.|....:|:.|:..|||||||.|.:|||.|..
Frog   293 TICGKGFTCISNLNVHQRSHTGERPFSCGQCGKSFTNNSYLVRHQTTHTGERPYPCPICGKTFTR 357

Human   476 KHSVTIHQRIHT 487
            |..|..||:|||
Frog   358 KGHVVTHQKIHT 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF587	NP_116217.1	KRAB	15..70	CDD:214630
		KRAB	15..54	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..88
		C2H2 Zn finger	94..114	CDD:275368
		C2H2 Zn finger	122..142	CDD:275368
		C2H2 Zn finger	242..262	CDD:275368	12/20 (60%)
		C2H2 Zn finger	270..290	CDD:275368	11/19 (58%)
		COG5048	<273..568	CDD:227381	111/215 (52%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		C2H2 Zn finger	326..343	CDD:275368	8/16 (50%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	369..389	CDD:290200	13/19 (68%)
		C2H2 Zn finger	382..402	CDD:275368	10/19 (53%)
		zf-H2C2_2	394..419	CDD:290200	13/24 (54%)
		C2H2 Zn finger	410..430	CDD:275368	10/19 (53%)
		zf-H2C2_2	422..447	CDD:290200	15/24 (63%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
		zf-H2C2_2	450..473	CDD:290200	13/22 (59%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		zf-H2C2_2	478..503	CDD:290200	6/10 (60%)
		C2H2 Zn finger	494..514	CDD:275368
		zf-H2C2_2	509..530	CDD:290200
		C2H2 Zn finger	522..542	CDD:275368
		zf-H2C2_2	534..557	CDD:290200
		C2H2 Zn finger	550..570	CDD:275368
LOC100488006	XP_002937452.2	C2H2 Zn finger	124..144	CDD:275368	12/20 (60%)
		zf-H2C2_2	136..161	CDD:290200	10/24 (42%)
		C2H2 Zn finger	152..172	CDD:275368	11/19 (58%)
		zf-H2C2_2	164..189	CDD:290200	14/24 (58%)
		COG5048	<177..327	CDD:227381	77/149 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		zf-H2C2_2	193..217	CDD:290200	15/23 (65%)
		C2H2 Zn finger	208..228	CDD:275368	9/19 (47%)
		zf-H2C2_2	220..245	CDD:290200	12/24 (50%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	248..271	CDD:290200	13/22 (59%)
		C2H2 Zn finger	264..284	CDD:275368	10/19 (53%)
		C2H2 Zn finger	292..312	CDD:275368	10/19 (53%)
		zf-H2C2_2	304..329	CDD:290200	15/24 (63%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		zf-H2C2_2	332..357	CDD:290200	14/24 (58%)
		C2H2 Zn finger	348..368	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910