Protein Alignment MAP4K3 and KIC1

DIOPT Version :10

• Sequence 1: NP_003609.2
• Gene: MAP4K3 / 8491
• HGNCID: 6865
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_011970.1
• Gene: KIC1 / 856502
• SGDID: S000001144
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 733
• Identity: 193/733 - (26%)
• Similarity: 295/733 - (40%)
• Gaps: 183/733 - (24%)

Human    16 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQEIIMMKDCKH-PNIVAYFG 78
            |:..:.||.|.:|.|||..||.||.:.||||:.|:...| ...||:||..:...|. .||..|:|
Yeast    23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYG 87

Human    79 SYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANIL 143
            |||:...|||.||.|.||||:.:.. .|.:.|..|..:.||.|..|..:|....:|||||.||:|
Yeast    88 SYLKDTSLWIIMEHCAGGSLRSLLR-PGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVL 151

Human   144 LTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELA 208
            :|:.|:|||.||||:||:..|..:|::..||||||||||  :.....|:...|:|::|||..|:|
Yeast   152 ITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEV--IMEGVYYDTKVDIWSLGITTYEIA 214

Human   209 ELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 273
            ...||..|:..:||:.|:.||  :||:|:|: .:|.|...|:.:.|.::||:|.:|:.||:..|:
Yeast   215 TGNPPYCDVEALRAMQLIIKS--KPPRLEDR-SYSTSLKEFIALCLDEDPKERLSADDLLKSKFI 276

Human   274 TQHLTRSLAI--ELL-------DKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRS 329
            ..|.....:|  ||:       ||..|.     :..:...||...:.|......|:|...::.:.
Yeast   277 RAHKATPTSILKELISRYLLFRDKNKNK-----YKIEGSIPENEPSKPSEAPKPSQNGGGDEAQK 336

Human   330 EITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKS 394
            .|...    |..:::..|...|:......|.||:   |...:|::|..           |..:.:
Yeast   337 SIASN----DNEIKRVNEGDVEMKWDFDSLSSSD---YIIENNINLDA-----------LAEDNN 383

Human   395 LLKSVEEELHQRGHVAHLEDDEGDDDESKH-----------------------STLKAKIPPPLP 436
            ...:.:.:|.   :.|:.::|....|.:.|                       |||.|    |:.
Yeast   384 EWATAQHDLF---NYAYPDEDSYYFDPTSHNTRPFVYQGTTIGKGYPGTIAQNSTLNA----PVT 441

Human   437 PKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPR------------------PPPPRL 483
            ....:...|.:|.:......||....||:.|....|:.|.:                  ...|:
Yeast   442 NNYTNSKYPSKMVAGTTNTSGTHTAGPMTSSKRLESKAPKQLLELFEDNEIITAENDVNTEAPK- 505

Human   484 PPHKPVALGNGMSSFQL-NGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNG-------LPPTP 540
                   :...:||... |..||..:....||..|...:.|.:..:| |:|:|       .|..|
Yeast   506 -------ISKSISSLNAGNSSRDDFIPSISNEVNGNINNNKMRPHLP-PLSSGNNYYSQSTPALP 562

Human   541 KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCT 605
            .:.  ..|:|...|.|                       ..|:.|.      .||:|...|..
Yeast   563 LLQ--TKFNKTSKGPP-----------------------TSGLTTA------PTSIEIEIPEE-- 594

Human   606 WLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPA--------------------HK 650
                :.|..|.....|.                    ||.||:                    :|
Yeast   595 ----LPNSALPTPASAD--------------------PVLIPSTKARSSTVTAGTPSSSSSIQYK 635

Human   651 LPDRILPRKFSVSAKIPE 668
            .|..: ||:.:||...||
Yeast   636 SPSNV-PRRLTVSNNRPE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K3	NP_003609.2	STKc_MAP4K3_like	15..273	CDD:270788	109/258 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..536		32/174 (18%)
		CNH	561..874	CDD:214481	21/128 (16%)
KIC1	NP_011970.1	STKc_NAK1_like	21..295	CDD:270822	114/277 (41%)