Protein Alignment MAP4K3 and map4k3a

DIOPT Version :10

• Sequence 1: NP_003609.2
• Gene: MAP4K3 / 8491
• HGNCID: 6865
• Length: 894
• Species: Homo sapiens
• Sequence 2: XP_068080465.1
• Gene: map4k3a / 558281
• ZFINID: ZDB-GENE-130329-1
• Length: 971
• Species: Danio rerio
• Alignment Length: 972
• Identity: 726/972 - (74%)
• Similarity: 797/972 - (81%)
• Gaps: 79/972 - (8%)

Human     1 MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
            ||..||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
Zfish     1 MNSSFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVTTGELAAIKVIKLEPGEDFAVVQQEIIMM 65

Human    66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 130
            |||||.|||||||||||||||||.||:||||||||||||||||:|.|||||:|||||||||||:|
Zfish    66 KDCKHSNIVAYFGSYLRRDKLWISMEYCGGGSLQDIYHVTGPLTESQIAYVTRETLQGLYYLHNK 130

Human   131 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLC 195
            ||||||||||||||||||:|||||||||||||||:|||||||||||||||||||||||||||.||
Zfish   131 GKMHRDIKGANILLTDNGYVKLADFGVSAQITATLAKRKSFIGTPYWMAPEVAAVERKGGYNHLC 195

Human   196 DLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKK 260
            |:||||||||||||||||||||||||||||||||||||||||||:||:|:||:|||:||||||||
Zfish   196 DIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKVKWTNNFHNFVKLALTKNPKK 260

Human   261 RPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPE------------------- 306
            ||.|:||||||.|:|.|:|.||||||||.||||||:|.|.||||||
Zfish   261 RPPADKLLQHPLVSQPLSRILAIELLDKANNPDHSSYTDLDDDDPEPEFKYRGLFLPVSPLSRRV 325

Human   307 --------PLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSE 363
                    |.|:|||||.||||..||.||.|||.||||||||||..||:||||..|:|.|||.:|
Zfish   326 LRFAARRKPPVSVPHRIRSTSRTSREGKTLSEINFGQVKFDPPLTTETKPHHEQLDTDDFLDCAE 390

Human   364 EIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLE-DDEGDDD------- 420
            |||||||||||||::|.||...|..||.||||||||||||.||||.|||| ||||:||
Zfish   391 EIYYTARSNLDLQMDYEQGSPKGSILGGNKSLLKSVEEELQQRGHEAHLEDDDEGEDDGDDHDDE 455

Human   421 --ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDE--NQGTIKRCPMSGSPAKPS-QVPPRPPP 480
              .:|.||::.|:|||||||||....|.:..|.:.:  |||||||||...|||:.| .|||||||
Zfish   456 LQHTKSSTMRPKVPPPLPPKPKPSPGPHQSPSADPDRNNQGTIKRCPEPESPARSSTSVPPRPPP 520

Human   481 PRLPPHKPVALGNGMSSFQ---LNGERDGSLCQQ-------------------------QNEHRG 517
            ||||.:|..:|||.....:   ...:.|..:|.|                         .:||..
Zfish   521 PRLPAYKLSSLGNETHQEEHGLWGAQGDAGICSQFDQRLQVSFDDEENHDEEENSNGISPSEHSA 585

Human   518 TNLSR----------KEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRD 572
            :...:          |:|||.||||||||||||||||||||||||||||||||||:|||||||||
Zfish   586 STERQSTMPPAVPVPKDKKDFPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCATSWINPDTRD 650

Human   573 QYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYAR 637
            |||||||||||||||||||||||||||.|||||||||::|.||||||||..||||:|.|||::||
Zfish   651 QYLIFGAEEGIYTLNLNELHETSMEQLVPRRCTWLYVLSNSLLSISGKACHLYSHSLSGLFEHAR 715

Human   638 QMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWV 702
            |||||||:||.|||||:::|||||||.||||||.||||||||||||||||||||.|:||.|.|||
Zfish   716 QMQKLPVSIPTHKLPDKMIPRKFSVSNKIPETKGCQKCCVVRNPYTGHKYLCGAFQSSIALFEWV 780

Human   703 EPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFT 767
            |.||||||:|.||||:||||.:||||||||.:|||:|:.||:|.:.||||||||:||||||:||
Zfish   781 ETMQKFMLVKSIDFPLPCPLEVFEMLVVPEHQYPLICIAVSKGTELNQVVRFETLNPNSTSNWF- 844

Human   768 ESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLA 832
            :|||||:.|.|||||||||||||||.||||||||||||||||||:||||:|||||||||||||||
Zfish   845 DSDTPQSCVIHVTQLERDTILVCLDRCIKIVNLQGRLKSSRKLSAELTFNFQIESIVCLQDSVLA 909

Human   833 FWKHGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY 894
            ||:||||||||:|||:||||||::||||||||||||||||||||||||:|||||||||||||
Zfish   910 FWRHGMQGRSFKSNEITQEISDNSRIFRLLGSDRVVVLESRPTDNPTAHSNLYILAGHENSY 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K3	NP_003609.2	STKc_MAP4K3_like	15..273	CDD:270788	238/257 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..536		68/176 (39%)
		CNH	561..874	CDD:214481	260/312 (83%)
map4k3a	XP_068080465.1	STKc_MAP4K3_like	15..273	CDD:270788	238/257 (93%)
		CNH	639..951	CDD:214481	260/312 (83%)