Protein Alignment MAP4K3 and hppy

DIOPT Version :10

• Sequence 1: NP_003609.2
• Gene: MAP4K3 / 8491
• HGNCID: 6865
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Alignment Length: 1224
• Identity: 496/1224 - (40%)
• Similarity: 634/1224 - (51%)
• Gaps: 356/1224 - (29%)

Human     6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 70
            |:||||||:::||||:||||||||||||:.:.:.||||||||||||.:|..::|||||||:||:|
  Fly    16 DISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRH 80

Human    71 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHR 135
            |||:||:|||||||||||||||||||||||||.|||||:|:||||:.||||:||.||||.|||||
  Fly    81 PNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHR 145

Human   136 DIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAV 200
            ||||||||||:.|.||||||||||||||||.||||||||||||||||||||||||||||||:||.
  Fly   146 DIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAC 210

Human   201 GITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAE 265
            ||||||||||||||||||||||||||:||.|:||.|.:|.|||.:||:|:|.|||||||||||||
  Fly   211 GITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAE 275

Human   266 KLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHS--TSR-------- 320
            :|||||||...::..:|.|||.|..:|:...|:..|.|: |.:..||.||.|  |||
  Fly   276 RLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDE-ESVAGVPQRIASKMTSRTNGVPAQN 339

Human   321 -------------NVR-------------------EEKTRSEITFGQVKFDP------------- 340
                         |.|                   |.|.|:.:.......||
  Fly   340 HTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHNGG 404

Human   341 -----------------------------------------------PLRKETEPHHELPD---- 354
                                                           |........|:||.
  Fly   405 AAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQQQQQ 469

Human   355 --------------------SDGF-------LDSSEEI--------YYTARSNLDLQLEYGQGHQ 384
                                |.|.       :.||..:        |...||::       .||.
  Fly   470 QSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHV-------VGHM 527

Human   385 G-GYFLGANKSLLKSV-----EEEL----------------------------------H----- 404
            | |:.:|...|.|::.     ::||                                  |
  Fly   528 GMGFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYS 592

Human   405 ---------QRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEM----HSTEDE-- 454
                     |....||...:...:..:.|.  .|.|...:.....|......:    :|:.|.
  Fly   593 SNYRSAAAAQASQAAHPHVNSNSNSNNGHG--HAPITSSISSSASSASFYNRLLLLDNSSGDAVV 655

Human   455 --NQGTIKRCPMSGSPAKPSQ-VPPRPPPPRLPPHKPVALGNGMSSFQ---------LNGERD-- 505
              |.|.......||..:..:. :..:.....||.....:.|:|.|...         ..|.||
  Fly   656 GGNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDND 720

Human   506 -----------------------------GSLCQQQNEHRGTNL--------------------- 520
                                         |:.|..::|:....|
  Fly   721 GPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMG 785

Human   521 --------------------------------------SRKEKKDVPKPISNGLPPTPKVHMGAC 547
                                                  |.|.:...|:|||||||||||||||||
  Fly   786 KSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGAC 850

Human   548 FSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNN 612
            |||:||||||::||.:|||:|:||||:|:.|||||||.||:||||:.:::||||||.|||||:.:
  Fly   851 FSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKD 915

Human   613 CLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCV 677
            .|:|:|||:.|||.|:|..|    ...|.:..::..:|:|:|::||||:::.|:|:||.|.:|||
  Fly   916 VLMSLSGKSCQLYRHDLVAL----HSKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCV 976

Human   678 VRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFP----------------IPCPLRMFE 726
            .||||.|:||||||..:.|.|::|.:|:.||||:|..::|                .|    :||
  Fly   977 TRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTP----VFE 1037

Human   727 MLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESD---------TPQTN---VTHV 779
            |::.||.|||:||.||.:.  .|..::.|.:|.|| :|||...|         .|:.:   |..|
  Fly  1038 MIITPELEYPIVCTGVRKA--MNGCLKLELINMNS-ASWFHSEDLEYDAMATMVPRRDLLKVVRV 1099

Human   780 TQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFR 844
            .|:|:|.||||....|::|.|||..|..:|:.|:|.|||.::|||||.||||||.||||||:|.|
  Fly  1100 HQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLR 1164

Human   845 SNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANS----NLYILAGHENSY 894
            :.||||||.|.:|.:||||||:||.|||:.....:..|    :||||||||.||
  Fly  1165 NGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY 1218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K3	NP_003609.2	STKc_MAP4K3_like	15..273	CDD:270788	211/257 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..536		31/233 (13%)
		CNH	561..874	CDD:214481	164/340 (48%)
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	211/257 (82%)
		CNH	864..1193	CDD:470577	163/339 (48%)