Protein Alignment MAP4K3 and gck-2

DIOPT Version :10

• Sequence 1: NP_003609.2
• Gene: MAP4K3 / 8491
• HGNCID: 6865
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_504721.1
• Gene: gck-2 / 179072
• WormBaseID: WBGene00022603
• Length: 829
• Species: Caenorhabditis elegans
• Alignment Length: 941
• Identity: 363/941 - (38%)
• Similarity: 516/941 - (54%)
• Gaps: 175/941 - (18%)

Human     7 LSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHP 71
            :.|.||.:|:||:||:||||||:|||||::.:..|||:||:|||.|::|||:||||:::::|.||
 Worm     6 IKRSNPADDYELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAVIQQEIMVIRECSHP 70

Human    72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRD 136
            ||:||||||:|||:|||.||:|||||||||||:||||||||||:|.||||:||.|||:.||:|||
 Worm    71 NIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKIHRD 135

Human   137 IKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVG 201
            ||||||||:.:|.||||||||:|||||||.|||||||||||||||||.||::|||...||:||.|
 Worm   136 IKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMQCDVWATG 200

Human   202 ITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEK 266
            ||||||.|.|||:||||||:.|:|||||.::||.||||.:|:..||.||:..|||||||||:.||
 Worm   201 ITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWTPLFHDFVRQCLTKNPKKRPSPEK 265

Human   267 LL-QHPFVTQHLTRSLAIELLDKVNNP------------DHSTYHDFDDDDPEPLV---AVPHRI 315
            || .||||...|:..:..:||||||..            |..|..:.|.||...|:   |.|.||
 Worm   266 LLTSHPFVLGSLSARMTRDLLDKVNGAPTDVYDRMSKTVDDLTEEESDMDDAPSLLTPDAAPIRI 330

Human   316 ----H--------------STSRNVREEKTRSEITFGQVKFDPPLRKE-TEPHHELPDSDGFLDS 361
                |              |:|.|...|..|...|......:.....| |.|..|:|
 Worm   331 GLPAHLNGLRLDARCLEQLSSSPNTSSESDRRTPTATPRSLNRGYHSERTLPAKEMP-------- 387

Human   362 SEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSV---EEELHQRGHVAHLEDDEGDDDESK 423
                                             ||..|   :..||....|.|      ||||
 Worm   388 ---------------------------------LLPDVVGGDALLHCGNGVIH------DDDE-- 411

Human   424 HSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKP 488
              ||:|                                              ||.||..|...:.
 Worm   412 --TLRA----------------------------------------------PRAPPRTLRAAQK 428

Human   489 VALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFN 553
            .|.||..:.|.     ..|:....:|...|...             |:|..|||.||||||||.:
 Worm   429 AAAGNSKNRFS-----STSIASTPSEDGLTTFF-------------GMPLIPKVPMGACFSKVMD 475

Human   554 GCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSIS 618
            ...|||:||:||::|.|....|:||.|:|||:.:.|.:.:.::.::..|||:|::|..:.|.:|.
 Worm   476 RTELKINCAASWVHPLTGAHLLLFGTEQGIYSFDTNCMPDGNLSKIHHRRCSWMFVYADRLTAIQ 540

Human   619 GKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVR--NP 681
            |....:|.|:|..|   .::...|.::...:|:|::.:|::.:::.::|||:...:|.|.|  ..
 Worm   541 GNTPYVYRHDLVAL---TQKNLTLKMSKNLNKIPEKYVPKRLAITVRMPETRGALQCTVKRGQGA 602

Human   682 YTGHKYLCGALQTSIVLLEWVEPMQKFMLIKH--IDFPIPCPLRMFEMLVVPEQEYPLVCVGVSR 744
            .....:||.|::.::.|.:|..||.:|:|::.  |...|..|:|.|.::.....::|.:|:||.:
 Worm   603 QANSLFLCCAVRKTVHLFQWYNPMNQFVLVRSEPIREDIRFPIRPFALINSRTSDFPELCIGVGQ 667

Human   745 GRDFNQ----VVRFETVNPNS------TSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVN 799
            ....|:    ::.|.:...||      .||:.:.:|.....|..:.|::|||:.......:.:.:
 Worm   668 MSGSNEYQFNMINFCSSTNNSELSGDLNSSYGSLADDEMLEVGSMHQIDRDTLCFSFRNKVVLTD 732

Human   800 LQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDSTRIFRLLGS 864
            |||   ..|...|..||:|.||.:..:..::|||..:|:|||..:||..||::.|.:|::|::|.
 Worm   733 LQG---FERPKPSIFTFNFHIEYLHVVDGTILAFHANGVQGRDLKSNLNTQDLCDVSRLYRVIGD 794

Human   865 DRVVVLESRPTD--NPTANSNLYILAGHENS 893
            |||::|.|:|..  |.....::.:|.||.::
 Worm   795 DRVIILRSQPMSPRNSGDTCDVSLLMGHTDT 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K3	NP_003609.2	STKc_MAP4K3_like	15..273	CDD:270788	186/258 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..536		20/125 (16%)
		CNH	561..874	CDD:214481	96/326 (29%)
gck-2	NP_504721.1	STKc_MAP4K3_like	14..273	CDD:270788	186/258 (72%)
		CNH	483..804	CDD:214481	96/326 (29%)