Protein Alignment ARHGEF39 and RhoGEF4

DIOPT Version :10

• Sequence 1: NP_116207.2
• Gene: ARHGEF39 / 84904
• HGNCID: 25909
• Length: 335
• Species: Homo sapiens
• Sequence 2: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Alignment Length: 332
• Identity: 82/332 - (24%)
• Similarity: 151/332 - (45%)
• Gaps: 33/332 - (9%)

Human     7 GSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWE 71
            ||..|...:|..:.|:   ..:|::.:|:.|.|||.|:..:|:..||.:..:.......|||..|
  Fly    58 GSPNPDAGKRLGFRRQ---AIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIE 119

Human    72 LIYGASQELLPYLEGGCWGQGLEGFCR-------HLELYNQFAANSERSQTTLQEQLKKNKGFRR 129
            :|:..:.|.|..||.     .:|....       ..:||:.:|.:...:...:|:.:.||..||:
  Fly   120 MIHNLNGEFLRELEA-----NMENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRK 179

Human   130 FVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRV 194
            |:...|.|||. ..:|..|:.:|:||:.:|:.|:..:...|.|...|::.|..:.:.|..||..:
  Fly   180 FLEQTESRPEV-QRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHI 243

Human   195 HTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLL--- 256
            :|..::|:..|:|..:|..|..|....:...|..:::|.|..:...|....|...|.:|:.:
  Fly   244 NTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEIKRYCVLMSDIFMYCK 308

Human   257 MAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLLSLSFPHEKLLLMSTDQEELSR 321
            |.|.|.| :.:...:..|..::|:.:|.:..:.       .|...|:...:.::..|.| .:|||
  Fly   309 MIKERAP-NTVVENSLECCCIFPLKKCKVYEML-------PGNFKLTCQSDGIIFGSGD-VQLSR 364

Human   322 WYHSLTW 328
                 ||
  Fly   365 -----TW 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF39	NP_116207.2	RhoGEF	27..195	CDD:459876	47/174 (27%)
		PH-like	225..>269	CDD:473070	11/46 (24%)
		PH	230..331	CDD:459697	22/102 (22%)
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:459876	47/175 (27%)
		PH-like	269..>311	CDD:473070	8/41 (20%)
		PH	277..374	CDD:459697	22/104 (21%)