Protein Alignment CEP89 and cep89

DIOPT Version :10

• Sequence 1: NP_116205.3
• Gene: CEP89 / 84902
• HGNCID: 25907
• Length: 783
• Species: Homo sapiens
• Sequence 2: XP_017212319.1
• Gene: cep89 / 393852
• ZFINID: ZDB-GENE-040426-1210
• Length: 865
• Species: Danio rerio
• Alignment Length: 809
• Identity: 360/809 - (44%)
• Similarity: 508/809 - (62%)
• Gaps: 83/809 - (10%)

Human     6 RRGRRSHFKHIIHGLLPAASVAPKAAVPRTPPPRSPNPSPERPRSALAAAILATTLTGRTVAIPQ 70
            ||..:..|::|.|||:|||::||:.|||||||||||||||||||||||||||:::|||||||||.
Zfish    26 RRKEKREFRNIAHGLIPAATIAPRPAVPRTPPPRSPNPSPERPRSALAAAILSSSLTGRTVAIPS 90

Human    71 PRQRSRSESDVSSVEQDSFIEPYATTSQLRPRPNWQSEMGRRSSLPSFETLDYGDEEDIETQLSS 135
            |||||.||||.|..:..:..|||||.  |..|..|...:..|..:||....|..|:||.|
Zfish    91 PRQRSYSESDCSRADSQADFEPYATA--LYTRDRWPGSVTGRPPVPSPGRTDEDDDEDDE----- 148

Human   136 SGKELGDVSARE----------DRGGHSDDL---YAVP--HRNQVPLLHEVNSEDDENISHQDGF 185
             |.::.::...|          :|...:||:   ||||  |:..     |::|:.||. :....|
Zfish   149 -GNDIDELEGLEGDEDHVYQSLERQSRADDINVVYAVPLKHKKS-----EIDSDVDEE-TEDSAF 206

Human   186 ---------------------PGSPPAPQRTQQKDGKHPVL-------NLKDEKPPLCEKPPPSP 222
                                 |.|.|.|:...::....|.|       :||..|.........||
Zfish   207 DIVSPLQTEEETVVPEGAAQTPSSLPQPRSVSRRSMASPELDDWSSPRSLKTSKRKSSRTNKESP 271

Human   223 DITGRARQRY---TEITREKFEA-------LKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKG 277
             :....|.|.   :|:.|...|.       |||:|..|:...::|........|.||.||.:|..
Zfish   272 -VRVNERDRSSEDSEVLRSTLEVQHALVKELKEQNQILSQEKETLEKRCLQQSQHMKHLQQELCH 335

Human   278 MEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKE 342
            ..:|:..       |:.|  ..||..||:|||||||||||||||||||||||||||.:||.|:|:
Zfish   336 THRERGN-------STGE--GSELSSLRQQAQELVDENDGLKMTVHRLNVELSRYQARFRPLTKD 391

Human   343 ESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEE 407
            |:..::|||.|||.||||||:||||||||||||.:..||:|..:.:||::..|:|.:||::|||:
Zfish   392 ENAQLKGLPVKGPAPPWLLDMKYLSPLLLAYEDHLNAKDKLLKSCEEELQSLRVRAEEVIQENEK 456

Human   408 LHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLL 472
            ||.:::|||.|:::||||||.||:||||||::|:||||:|..|||::|.:..|||.|::|::|||
Zfish   457 LHTQVSKSSTVSNKEWRQLQEQARLVLEENQVLIEQLELQHAKAKEAHSKHAQEVCKVSKKVMLL 521

Human   473 EAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEE 537
            ||:....||||...|::...|:.:.|.::...:..:::..|:::.::||.|||..|:.:..|:|:
Zfish   522 EAEKQSLEKELEVERKEHRALKTEFQRVRLALEHSLSLAEHQTVTDKLKRQLQDHEKVKTCEVED 586

Human   538 LMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAH 602
            |..:|:.|:.::|:|||:|.:|....|.||.||:.:|:.|||:|::|.|||:|||.::..|:.||
Zfish   587 LQVRLSALEVERKTLLLDKTNLNTHIKHLETELQLSQQANRKAQRRISVLKQQVEDSLEKELIAH 651

Human   603 QYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGD 667
            |||||:|.|||..|.|||.||.:|..||.:|.|||.::|:|.:.||||:||||.|||||:..:..
Zfish   652 QYLANIVTLAEKTTHERDQLMLMASTLEKDKQGVLTRIIESTVNLGKLQEKVKVYKKQASASVCA 716

Human   668 ISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRI 732
            :..||.||:||||||:|.|::|:|||...|:|:||.|..||||.||:||||||:||:..||::|:
Zfish   717 LGRRLREQEEDFAGKSASYQREIRHLQNQLRDRQEQLHGALQQKREVEGELEVVWEAATRESQRL 781

Human   733 RELLQDTLTRTGVQDNPRALVAPSLNGVS 761
            ||::..:.:.:.|      .|||:|:..|
Zfish   782 REVVLRSSSLSPV------TVAPALHSTS 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CEP89	NP_116205.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..49		18/20 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..157		38/106 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..226		14/77 (18%)
		EnvC	260..>496	CDD:443969	127/235 (54%)
		Smc	<421..>767	CDD:440809	162/341 (48%)
cep89	XP_017212319.1	CCDC158	<257..>588	CDD:464943	152/340 (45%)
		Smc	433..>786	CDD:440809	171/352 (49%)