Protein Alignment CEP89 and C14H10.2

DIOPT Version :10

• Sequence 1: NP_116205.3
• Gene: CEP89 / 84902
• HGNCID: 25907
• Length: 783
• Species: Homo sapiens
• Sequence 2: NP_001359535.1
• Gene: C14H10.2 / 181234
• WormBaseID: WBGene00007592
• Length: 700
• Species: Caenorhabditis elegans
• Alignment Length: 598
• Identity: 133/598 - (22%)
• Similarity: 242/598 - (40%)
• Gaps: 142/598 - (23%)

Human   219 PPSPDITG------RARQRYTEITRE-----------KFEALKEENMDLNNMNQSLTLELNTMKQ 266
            |.||..||      .|....|.:::|           |.|.:::..||...:|.|||:....:|:
 Worm    10 PESPFRTGTPSRMPSAFGEKTYVSKEEHEKERSRWLGKMEEVEKRLMDAETLNSSLTINKAELKK 74

Human   267 AMKELQLKLKGMEKEKRKLKEAEKASSQEV---------AAPELLYLRKQAQELVDENDGLK--- 319
            .:.:::...:.|....|||.:..|...|||         :..:.|.|:...:.|:.||..||
 Worm    75 KIVDMEKGQRPMIDANRKLSDRNKVLQQEVKKVEQRFSHSRDDFLTLKDIHERLLKENACLKEKR 139

Human   320 MTVHRLNVELSRYQTKFRHLSK----------EESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYE 374
            ::..:|. |||||:.|....||          |:....|.|..|         .|.|...|...|
 Worm   140 VSPEKLE-ELSRYRNKVLEYSKCITALRSSAYEKDKRYEMLVQK---------FKRLQKCLKKSE 194

Human   375 D----MMKEKDELNA-------TLKEEM-RMFRMRV----QEVVKENEELHQELNKSSAVTSEEW 423
            :    |.....:.:|       |:.|:. .:|...:    |.:.:||.||.:.||:....||:
 Worm   195 NDDDRMSNGGSDCSAASTVSLDTITEDFEEVFAKDIETDYQALYRENAELQRALNELQLNTSD-- 257

Human   424 RQLQTQAKLVLEENKLLLEQLEI------QQRKAKDSHQERLQEVSKL-------TKQLMLLEAK 475
                      |.|...|.:|:..      ||:...|:.|:.:.:.::|       .:.:..||..
 Worm   258 ----------LSEESFLRDQISFANSTIEQQQLVIDATQDMMSQTAQLKSTIAGQQEHIRSLETT 312

Human   476 THGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKE-EEKERAEMEELM 539
            ....::::|...|:.::|..:..|::.:...:..:...:|.....|:||.|| :|.::|...:|
 Worm   313 VDDLKQQIASQTERNDVLEFQVLEMEENQKQQDTIAAKQSTFESEKTQLLKELDEVKKAHANQL- 376

Human   540 EKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQY 604
                      ||:.|.|..| |.:||....:    |......::::.|:::.|||....:|.::.
 Worm   377 ----------KSIALIKKEL-EDHKAAAPSV----KPTLSESEQVDALQQKFEKAEAANVSINEE 426

Human   605 LAN-----------LVGLAENITQERDSLMCLAKCLES----------EKDGVLNKVIKSNIRLG 648
            |.:           :.|...::::||.....|:..|:|          :|:..|.| :|:.:.|.
 Worm   427 LRSASKELGKIRFQMQGKESDLSRERKMTEALSAQLQSVVSSSQEEALKKEEELKK-LKATVELQ 490

Human   649 KLE-EKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMR-HLHQVLKDKQEVLDQALQQN 711
            :.| ||:...||:|     |...:.||::      .|.||.|.| .:...|:.:.|.....|:..
 Worm   491 QAEIEKMHEDKKEA-----DQKFKNLEKE------YAAYRDEQRPEIKTELERRYEEAKYRLKNA 544

Human   712 REMEGELEVIWES 724
            .|...:.|:::|:
 Worm   545 LEKIHDYELLYEA 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CEP89	NP_116205.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..49
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..157
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..226		3/6 (50%)
		EnvC	260..>496	CDD:443969	61/286 (21%)
		Smc	<421..>767	CDD:440809	70/341 (21%)
C14H10.2	NP_001359535.1	SMC_N	121..>469	CDD:481474	82/385 (21%)
		SMC_prok_B	306..>634	CDD:274008	61/280 (22%)