Protein Alignment CEP89 and cep89

DIOPT Version :10

• Sequence 1: NP_116205.3
• Gene: CEP89 / 84902
• HGNCID: 25907
• Length: 783
• Species: Homo sapiens
• Sequence 2: XP_004913612.2
• Gene: cep89 / 100494656
• XenbaseID: XB-GENE-1003479
• Length: 801
• Species: Xenopus tropicalis
• Alignment Length: 778
• Identity: 373/778 - (47%)
• Similarity: 531/778 - (68%)
• Gaps: 58/778 - (7%)

Human     1 MLLGFRRGRRSHFKHIIHGLLPAASVAPKAAVPRTPPPRSPNPSPERPRSALAAAILATTLTGRT 65
            |...|||..|:.||||.|||:|||:|||::|||||||||||||||||||||||||||.|:|||||
 Frog     1 MSFPFRRRSRNEFKHIAHGLIPAATVAPRSAVPRTPPPRSPNPSPERPRSALAAAILMTSLTGRT 65

Human    66 VAIPQPRQRSRSESDVSSVEQDSFIEPYATTSQLRPRPNWQSEMGRRSSLPSFETLDYGDEEDIE 130
            ||||||||||.||:|.:.:|:.|.|:||||...|....||:....|::.:....:.:: |:||.|
 Frog    66 VAIPQPRQRSYSENDSTYMEESSTIDPYATARDLGLEQNWKEYRARQNIVSPVMSFNF-DDEDTE 129

Human   131 TQLSSSGKELG-DVSAREDRGGHSDDLYAVP-HRNQVPLLHEVNS-------------------- 173
            .::|...:|.. ::|.:::.....:.:|::| .:.:..:|.|:.|
 Frog   130 EEMSDIEREHAVNISEKKEEMQSHEPIYSLPLKKKKETILPEIASKLSSQRAELLNSPTMSGPEQ 194

Human   174 EDDENISHQDG--FPGSPPAP--------------QRTQQKDGKHPVLNLKDEKPPLCEKPPPSP 222
            :::|:|   ||  .|.:.|.|              :.|:||..|..:   |.:......|.|..|
 Frog   195 QEEESI---DGRVDPSASPPPTKQTSERPLEQNQGRETKQKQNKEII---KSDGSLTLNKDPVIP 253

Human   223 DITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKE 287
            .:             .:.|.|:..|:.|::.||:|:.:|..:|..:|.:::|||.::.|||.|.:
 Frog   254 SM-------------NEAEQLRARNLYLSDENQALSNKLQELKNQIKAMRIKLKEVKNEKRDLSQ 305

Human   288 AEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPS 352
            :.|....:..|.||..||:|||||||:||.||.||:||||||||||||||.|.|:|.:.:..||.
 Frog   306 SIKRQQTDAEAAELASLREQAQELVDQNDALKTTVYRLNVELSRYQTKFRPLLKDEKVKLGSLPQ 370

Human   353 KGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSA 417
            |||.||||||:||||||||||||.|:|||:|..:.:||::.|:.||::||:||::||.||.....
 Frog   371 KGPPPPWLLDMKYLSPLLLAYEDRMREKDDLLISFEEEVKNFKTRVKKVVEENKQLHNELQGKRD 435

Human   418 VTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKE 482
            :|:.||:.:|.|||||||||:.|:|||:::|.|||::.:..|.||::||||:|:||.|...:|:|
 Frog   436 ITNAEWQLIQAQAKLVLEENQTLMEQLQVEQAKAKETERNHLMEVTRLTKQMMVLEGKNQSREEE 500

Human   483 LAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQA 547
            |.|.::|.|:||:|..|||.:.:||:|.|.|.::|||||||:|..::|.:.|.::|::|:..||.
 Frog   501 LLEFQKQQEVLRSKYDELKANMEGKVAAEEHVAMVNELKSQIQHIQDKSKREEKDLIDKIATLQL 565

Human   548 QKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLA 612
            ||||||||:|:|...||.|:||.|..:|:|||.|:|:..||:|:|.|:..|::|||||||::.||
 Frog   566 QKKSLLLERNNLLADNKILDAEGETVKKLNRKLQRKLGHLKQQLEDALEKEVAAHQYLANIITLA 630

Human   613 ENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQE 677
            |||:.|||.||.:||.|::||....||:::.|:||.||||.||.|||:||.||.||||||.||:|
 Frog   631 ENISLERDELMQVAKSLKTEKHSFFNKMLEGNVRLEKLEELVKVYKKKAAGKLQDISHRLSEQEE 695

Human   678 DFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTL 740
            |||||..||::|||||.::|:|:|:.||:.|||.|::||||||:||||..||:::::||..||
 Frog   696 DFAGKAVQYQREMRHLQRLLQDRQQTLDEVLQQKRQVEGELEVMWESTSNENKQLKDLLHKTL 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CEP89	NP_116205.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..49		18/20 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..157		34/94 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..226		15/65 (23%)
		EnvC	260..>496	CDD:443969	127/235 (54%)
		Smc	<421..>767	CDD:440809	176/320 (55%)
cep89	XP_004913612.2	Smc	<256..>754	CDD:440809	267/497 (54%)