Protein Alignment MIGA2 and Miga

DIOPT Version :10

• Sequence 1: NP_116198.3
• Gene: MIGA2 / 84895
• HGNCID: 23621
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_572476.2
• Gene: Miga / 31775
• FlyBaseID: FBgn0030037
• Length: 525
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 189/559 - (33%)
• Similarity: 289/559 - (51%)
• Gaps: 99/559 - (17%)

Human   103 RLTPGLRKVLFATALGTVALALAAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKG 167
            |::...:.|||:...|...:::.:..|:||:                 .|.|...|||
  Fly    19 RVSTTTKVVLFSLTAGVALMSVLSRFLRRRK-----------------PPRPPRRARK------- 59

Human   168 YSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSVASMMAVNSSSPTAACS------GLWDARGM 226
            |:.||.::.....||.:| |:..:.|..|||  .|.|.:|.:.....|:.|      |:.:| |.
  Fly    60 YTGRRNRNSMRSPNDLIS-IAGSKASARSGS--PVGSTLAYSDRLSMASGSIGVGVLGVQNA-GP 120

Human   227 EESLTTSDGNAESLYMQGMELFEEALQKWEQALSVGQRGDSGSTPMPRDGLRNPETASEPLSEPE 291
            ..|:.| ...|:.|.|.|||..:..:..||.||:      :..:|   .||        |.....
  Fly   121 GSSVVT-QLTAQQLGMMGMEALDTVINFWEDALA------AHYSP---GGL--------PALLTT 167

Human   292 SQRKEFAEKLESLLHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTE------------------ 338
            ::..||..::::||..||.|||:        |.||.|::..:|...|
  Fly   168 AEDSEFCREIQNLLEMAYTLQEQ--------SELLFLDQRSVLFREEHSIDEAEEEAGEADDDRR 224

Human   339 ----GSLRLRADDEDSLTSEDSFFSATELFESLQTGD---------YPIPLSRPAAAYEEALQLV 390
                ||:..||..:.:..|.:||.||.:....|:..|         ||:        ::.||:..
  Fly   225 SRKSGSVLSRAGSDPNFDSAESFASALDQVADLREFDGFIETSYEEYPL--------FQSALKHH 281

Human   391 KEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEDKSNQLFFGKVGRQMVTGLMTKAEKS 455
            .|..|||||:|.||:.|.:|.::||||||||.||:.|.:|.:...:....|||::|.|:...:|.
  Fly   282 DEYTVPCRTIRAELMHCSTDTEYLAKLHCVRLAFQFLFKDPAVGQWICDAGRQILTDLLCLGDKD 346

Human   456 PKGFLESYEEMLSYALRPETWATTRLELEGRGVVCMSFFDIVLDFILMDAFEDLENPPASVLAVL 520
            .|.||..||:|::|......|...::|||.|.|..|:|:||.||||::|:|:||:.|||||.||:
  Fly   347 TKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFYDICLDFIILDSFKDLDAPPASVTAVV 411

Human   521 RNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLAEVC 585
            :|||||:.||||||.||.|||||||:|:|..|:||:||||.:||.:||::|:||.||...|.::|
  Fly   412 QNRWLSNGFKETALTTAVWSVLKAKKRMLKFPNGFMSHFYVISEQISPLMAWGFFGPNENLRDIC 476

Human   586 AFFKHQIVQYLRDMFDLDNVRYTSLPALADDILQLSRRR 624
            .:|:.:::.:|.|:|.....|:|::...:.|:||..:.|
  Fly   477 HYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTR 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MIGA2	NP_116198.3	Miga	95..632	CDD:463034	189/559 (34%)
Miga	NP_572476.2	Miga	13..523	CDD:463034	189/559 (34%)