Protein Alignment SPPL2A and Spp

DIOPT Version :10

• Sequence 1: NP_001425040.1
• Gene: SPPL2A / 84888
• HGNCID: 30227
• Length: 538
• Species: Homo sapiens
• Sequence 2: NP_523444.1
• Gene: Spp / 33227
• FlyBaseID: FBgn0031260
• Length: 389
• Species: Drosophila melanogaster
• Alignment Length: 390
• Identity: 108/390 - (27%)
• Similarity: 180/390 - (46%)
• Gaps: 84/390 - (21%)

Human   163 PSWPN---FDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVV 224
            ||.|.   ..|:.:|  |:|:..:..|...|  |:|..||..|.|..:...||:         .:
  Fly    34 PSTPEGMAVAYSSLV--VMAMLPIIFGSIRS--VKLHKLKKSTGEKADTMTKKD---------AM 85

Human   225 IFVVICCVMMVLLYFFYK-----WLVYVMIAIFCIASAMSLYNCLAALIH--------KIPYGQC 276
            .|.:|....:..||.|:|     .:.|::...|.:...::|.:.|:.:|:        |:|:...
  Fly    86 YFPLIASAALFGLYLFFKIFQKVHINYLLTGYFFVLGVIALAHLLSPVINSLMPAAVPKVPFHIL 150

Human   277 TIACRGKNME--VRLIFLSG--LCIAVAV---VWAVFRNEDRWAWILQDILGIAFCLNLIKTLKL 334
            .....||:.|  |...|.:.  :|:.::.   ||.:.:..    ||..::.|:||.:|.::.|.|
  Fly   151 FTKGEGKHKEDIVNYKFSTHDIVCLVISSAIGVWYLLKKH----WIANNLFGLAFAINGVEMLHL 211

Human   335 PNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKNDGNLVEATGQPSAPHE 399
            .||.:.||||..|..||:|:||        |.::||.:|..            .||
  Fly   212 NNFVTGVILLSGLFFYDIFWVF--------GTNVMVTVAKS------------FEA--------- 247

Human   400 KLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRF-DVQTGSSYIYYVSSTVAYA 463
              |:.:..|:.:..:.::.  ...::||.|||::||:.||...|| |.:...:.||:.|:.:||.
  Fly   248 --PIKLVFPQDLIENGLNA--SNFAMLGLGDIVIPGIFIALLLRFDDSKKRKTRIYFYSTLIAYF 308

Human   464 IGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENP 528
            :|::.|..|:.:.|..|||||||||..:.|..:||..|.|:|..:   :|:  ||     .||.|
  Fly   309 LGLLATIFVMHVFKHAQPALLYLVPACMGTPLLVALIRGELKVLF---AYE--DH-----PEEKP 363

Human   529  528
              Fly   364  363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPPL2A	NP_001425040.1	None
Spp	NP_523444.1	Peptidase_A22B	71..358	CDD:282158	90/337 (27%)