Protein Alignment ORAI1 and orai1a

DIOPT Version :10

• Sequence 1: NP_116179.2
• Gene: ORAI1 / 84876
• HGNCID: 25896
• Length: 301
• Species: Homo sapiens
• Sequence 2: XP_695046.5
• Gene: orai1a / 566671
• ZFINID: ZDB-GENE-110721-1
• Length: 225
• Species: Danio rerio
• Alignment Length: 239
• Identity: 184/239 - (76%)
• Similarity: 204/239 - (85%)
• Gaps: 15/239 - (6%)

Human    64 MSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTT 128
            |||||||:|||||||||||||||||:|||||||||||||||||.||:.||:||||||||||||||
Zfish     1 MSLNEHSLQALSWRKLYLSRAKLKATSRTSALLSGFAMVAMVECQLEEDHNYPPGLLIAFSACTT 65

Human   129 VLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVL 193
            |||||||||||||||||||:|||||||||||:|||||||||||||||||||||||||||||||||
Zfish    66 VLVAVHLFALMISTCILPNLEAVSNVHNLNSIKESPHERMHRHIELAWAFSTVIGTLLFLAEVVL 130

Human   194 LCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTS-GITPGQAAAIASTTIMVPFGLIFIVFAVHF 257
            |||||||||.:.|    .|.|       .||:.: ||:.|:|||||||||||||.|:||||||||
Zfish   131 LCWVKFLPLSQTP----VTQK-------ENVTQAPGISEGKAAAIASTTIMVPFALVFIVFAVHF 184

Human   258 YRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA 301
            |||||||||:||.:||..||:..::|:|||.||:   ....|:|
Zfish   185 YRSLVSHKTERQHEELEVLAKITQMQNQLDQRGE---ASSIHFA 225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI1	NP_116179.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51
		Required for generation of inwardly rectifying CRAC currents. /evidence=ECO:0000269|PubMed:19182790	3..47
		AKAP5 association region. /evidence=ECO:0000269|PubMed:33941685	39..59
		Interaction with STIM1. /evidence=ECO:0000269|PubMed:19249086	70..90		18/19 (95%)
		Orai-1	73..267	CDD:462291	161/194 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	205..225		4/19 (21%)
		Interaction with STIM1. /evidence=ECO:0000269|PubMed:24351972	272..292		10/19 (53%)
orai1a	XP_695046.5	None