Protein Alignment ORAI1 and Orai1

DIOPT Version :10

• Sequence 1: NP_116179.2
• Gene: ORAI1 / 84876
• HGNCID: 25896
• Length: 301
• Species: Homo sapiens
• Sequence 2: NP_001014004.1
• Gene: Orai1 / 304496
• RGDID: 1311873
• Length: 304
• Species: Rattus norvegicus
• Alignment Length: 304
• Identity: 271/304 - (89%)
• Similarity: 281/304 - (92%)
• Gaps: 3/304 - (0%)

Human     1 MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPP-PPPSAVTYPDWIGQSYSEVM 64
            |||||||||:.|:||||.||||:||||||||||||||||.|||| |||.||:|||||||||||||
  Rat     1 MHPEPAPPPNNSNPELPLSGGSSTSGSRRSRRRSGDGEPTGAPPLPPPPAVSYPDWIGQSYSEVM 65

Human    65 SLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTV 129
            ||||||||||||||||||||||||||||||||||||||||||||||.||||||||||.|||||||
  Rat    66 SLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYPPGLLIVFSACTTV 130

Human   130 LVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLL 194
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 LVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLL 195

Human   195 CWVKFLPLKKQPGQPRPTSKP--PASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHF 257
            |||||||||:|.|||.||..|  ||...|.:.:..|||||:|||||||.||||.||:||||||||
  Rat   196 CWVKFLPLKRQAGQPSPTKPPTEPAVVVANSSNNGGITPGEAAAIASTAIMVPCGLVFIVFAVHF 260

Human   258 YRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA 301
            |||||||||||||||||||||||||||||||||||.||||:|||
  Rat   261 YRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHSLTPGTHYA 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI1	NP_116179.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		42/50 (84%)
		Required for generation of inwardly rectifying CRAC currents. /evidence=ECO:0000269|PubMed:19182790	3..47		37/44 (84%)
		AKAP5 association region. /evidence=ECO:0000269|PubMed:33941685	39..59		16/20 (80%)
		Interaction with STIM1. /evidence=ECO:0000269|PubMed:19249086	70..90		19/19 (100%)
		Orai-1	73..267	CDD:462291	173/195 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	205..225		10/21 (48%)
		Interaction with STIM1. /evidence=ECO:0000269|PubMed:24351972	272..292		19/19 (100%)
Orai1	NP_001014004.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		40/47 (85%)
		Required for generation of inwardly rectifying CRAC currents. /evidence=ECO:0000250|UniProtKB:Q96D31	3..49		38/45 (84%)
		AKAP5 association region. /evidence=ECO:0000250|UniProtKB:Q96D31	39..60		16/20 (80%)
		Interaction with STIM1. /evidence=ECO:0000250|UniProtKB:Q96D31	71..91		19/19 (100%)
		Orai-1	74..270	CDD:462291	173/195 (89%)
		Interaction with STIM1. /evidence=ECO:0000250|UniProtKB:Q96D31	275..295		19/19 (100%)