DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ORAI1 and orai-1

DIOPT Version :10

Sequence 1:NP_116179.2 Gene:ORAI1 / 84876 HGNCID:25896 Length:301 Species:Homo sapiens
Sequence 2:NP_001254835.1 Gene:orai-1 / 175221 WormBaseID:WBGene00015648 Length:297 Species:Caenorhabditis elegans


Alignment Length:283 Identity:97/283 - (34%)
Similarity:149/283 - (52%) Gaps:56/283 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    10 SRSSP-ELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSL---NEHS 70
            |::.| |..|:|||::.|.              :||..|:..:.......:.|.|:..   ::|.
 Worm    52 SQTPPVENAPTGGSSSMGQ--------------SPPHHPANTSTNTATHHTLSPVIQCFQQDQHR 102

Human    71 MQA-LSWRKLY-LSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAV 133
            .:. ||.:..| ||||:|||||||||||:|||||.:||:|.  |...|..|||.....|::||:|
 Worm   103 GELDLSEKYNYDLSRAQLKASSRTSALLAGFAMVCLVELQY--DQSTPKPLLIVLGVVTSLLVSV 165

Human   134 HLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVK 198
            ||.|||:||||||.:||.      ...::|||.::..:|:|:|.|||.||.||||.|:.::.:||
 Worm   166 HLLALMMSTCILPYMEAT------GCTQDSPHIKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVK 224

Human   199 FLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVS 263
            |..:    |.|                        .|...:|.::||.|::|:||:...:::.||
 Worm   225 FTAV----GYP------------------------TAGYITTAMLVPVGVVFVVFSYLIHKNRVS 261

Human   264 HKTDRQFQELNELAEFARLQDQL 286
            |...|...:::.:.:|..::..|
 Worm   262 HSLGRFKHKVDTMKQFLDVEANL 284

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ORAI1NP_116179.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 11/41 (27%)
Required for generation of inwardly rectifying CRAC currents. /evidence=ECO:0000269|PubMed:19182790 3..47 10/37 (27%)
AKAP5 association region. /evidence=ECO:0000269|PubMed:33941685 39..59 3/19 (16%)
Interaction with STIM1. /evidence=ECO:0000269|PubMed:19249086 70..90 10/21 (48%)
Orai-1 73..267 CDD:462291 80/195 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..225 2/19 (11%)
Interaction with STIM1. /evidence=ECO:0000269|PubMed:24351972 272..292 2/15 (13%)
orai-1NP_001254835.1 Orai-1 108..263 CDD:462291 78/190 (41%)

Return to query results.
Submit another query.