Protein Alignment ORAI1 and Orai1

DIOPT Version :10

• Sequence 1: NP_116179.2
• Gene: ORAI1 / 84876
• HGNCID: 25896
• Length: 301
• Species: Homo sapiens
• Sequence 2: NP_780632.1
• Gene: Orai1 / 109305
• MGIID: 1925542
• Length: 304
• Species: Mus musculus
• Alignment Length: 304
• Identity: 274/304 - (90%)
• Similarity: 282/304 - (92%)
• Gaps: 3/304 - (0%)

Human     1 MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAP--PPPPSAVTYPDWIGQSYSEV 63
            ||||||||||.|:||||.||||:||||||||||||||||.|||  ||||.||:||||||||||||
Mouse     1 MHPEPAPPPSHSNPELPVSGGSSTSGSRRSRRRSGDGEPSGAPPLPPPPPAVSYPDWIGQSYSEV 65

Human    64 MSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTT 128
            |||||||||||||||||||||||||||||||||||||||||||||||.||||||||||.||||||
Mouse    66 MSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYPPGLLIVFSACTT 130

Human   129 VLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVL 193
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 VLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVL 195

Human   194 LCWVKFLPLKKQPGQPRPTSKPPASGAAANVS-TSGITPGQAAAIASTTIMVPFGLIFIVFAVHF 257
            ||||||||||:|.|||.||..|..|...||.| :||||||:|||||||.||||.||:||||||||
Mouse   196 LCWVKFLPLKRQAGQPSPTKPPAESVIVANHSDSSGITPGEAAAIASTAIMVPCGLVFIVFAVHF 260

Human   258 YRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA 301
            |||||||||||||||||||||||||||||||||||.||||:|||
Mouse   261 YRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHSLTPGTHYA 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI1	NP_116179.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		43/51 (84%)
		Required for generation of inwardly rectifying CRAC currents. /evidence=ECO:0000269|PubMed:19182790	3..47		38/45 (84%)
		AKAP5 association region. /evidence=ECO:0000269|PubMed:33941685	39..59		16/21 (76%)
		Interaction with STIM1. /evidence=ECO:0000269|PubMed:19249086	70..90		19/19 (100%)
		Orai-1	73..267	CDD:462291	175/194 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	205..225		10/19 (53%)
		Interaction with STIM1. /evidence=ECO:0000269|PubMed:24351972	272..292		19/19 (100%)
Orai1	NP_780632.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		41/48 (85%)
		Required for generation of inwardly rectifying CRAC currents. /evidence=ECO:0000250|UniProtKB:Q96D31	3..49		38/45 (84%)
		AKAP5 association region. /evidence=ECO:0000250|UniProtKB:Q96D31	39..61		16/21 (76%)
		Interaction with STIM1. /evidence=ECO:0000250|UniProtKB:Q96D31	72..92		19/19 (100%)
		Orai-1	75..270	CDD:462291	175/194 (90%)
		Interaction with STIM1. /evidence=ECO:0000250|UniProtKB:Q96D31	275..295		19/19 (100%)