DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ORAI1 and orai2

DIOPT Version :10

Sequence 1:NP_116179.2 Gene:ORAI1 / 84876 HGNCID:25896 Length:301 Species:Homo sapiens
Sequence 2:XP_012824392.1 Gene:orai2 / 100380109 XenbaseID:XB-GENE-5781666 Length:259 Species:Xenopus tropicalis


Alignment Length:262 Identity:212/262 - (80%)
Similarity:225/262 - (85%) Gaps:19/262 - (7%)


- Green bases have known domain annotations that are detailed below.


Human    44 PPPP----SAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAM 104
            |.||    ..|:||:||.:||.|:|||||||||||||||||||||||||||||||||||||||||
 Frog    13 PCPPQLQEEEVSYPEWISRSYVELMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAM 77

Human   105 VEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMH 169
            |||||:|||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    78 VEVQLEADHAYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMH 142

Human   170 RHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQA 234
            ||||||||||||||||||||||||||||||||:    ..|:.:|.          .||.::.|||
 Frog   143 RHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPV----NSPKLSSN----------DTSTVSSGQA 193

Human   235 AAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSH 299
            ||||||.|||||||:|||||||||||||||||||||||||||||.|:||||||||||...:|| |
 Frog   194 AAIASTAIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELNELAELAQLQDQLDHRGDPVQSPG-H 257

Human   300 YA 301
            ||
 Frog   258 YA 259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ORAI1NP_116179.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 3/10 (30%)
Required for generation of inwardly rectifying CRAC currents. /evidence=ECO:0000269|PubMed:19182790 3..47 1/2 (50%)
AKAP5 association region. /evidence=ECO:0000269|PubMed:33941685 39..59 8/18 (44%)
Interaction with STIM1. /evidence=ECO:0000269|PubMed:19249086 70..90 19/19 (100%)
Orai-1 73..267 CDD:462291 163/193 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..225 2/19 (11%)
Interaction with STIM1. /evidence=ECO:0000269|PubMed:24351972 272..292 17/19 (89%)
orai2XP_012824392.1 Orai-1 46..226 CDD:462291 163/193 (84%)

Return to query results.
Submit another query.