Protein Alignment KLHL22 and Keap1

DIOPT Version :10

• Sequence 1: XP_016884508.1
• Gene: KLHL22 / 84861
• HGNCID: 25888
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Alignment Length: 596
• Identity: 159/596 - (26%)
• Similarity: 259/596 - (43%)
• Gaps: 69/596 - (11%)

Human    74 TYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEE 138
            |:..:.:::..|:.:..:|..|:|.||||.|:.....||:::|:|:..||:.||.|||||.|...
  Fly    66 TFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSR 130

Human   139 VLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDV 203
            |.:.||...||.:||:|:||.::.::...|.:.|.||...|:|.:|..||.||...:|..|.:.:
  Fly   131 VQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGI 195

Human   204 YRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY 268
            ...||......|.::.:.:|.:||....:.:::.||...::.:|:..:.|.|..|.|||...|.:
  Fly   196 AHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKW 260

Human   269 HYSLEQVQADQISLH-EPPKLLETVRFPLMEAEVLQRLHDKLD-----PSPLRDTVASA---LMY 324
                  |:.|:.:.| :...:|..||...:....|:......|     |: .|:.:|..   |..
  Fly   261 ------VKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPA-CREYLAKIFKDLTL 318

Human   325 HRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSN 389
            |:...::.  ::|.|.     :.:...||.......:|  :|..::.:  .|........|| |.
  Fly   319 HKCPGVKE--RTPNTT-----RMIFVAGGFFRHSLDIL--EAYNVDDM--TWTTLANLRIPR-SG 371

Human   390 QGIAVLNNFVYLIGGDNN----------VQGFRAESRCWR-----YDPRHNRWFQIQSLQQEHAD 439
            .|.|.|....|.:||.||          |..:.|.:..||     ..|||.
  Fly   372 LGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHR-------------- 422

Human   440 LSVCVVGRYIYAV---AGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCG 501
            :.|.|:...:|||   ||.:||   |.||.|||..:.|..|.|:..:........:...:|...|
  Fly   423 VGVAVMDELMYAVGGSAGMEYH---NTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGG 484

Human   502 RRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYS 566
            ..|.:.|....||.|.:|.|..|......|:..|:|.:...:||:||.:.    .|.:..|..|.
  Fly   485 FDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDG----TRQLATVERYD 545

Human   567 CTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSI 631
            ..:..|..|.|:........:..||.::|.:||...|  :....|.:||...:.|..|..|.:..
  Fly   546 TENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGN--NFLSIVEVYDPRTNTWTTGTPLKSGR 608

Human   632 SGLAACVLTLP 642
            ||.|:.|:..|
  Fly   609 SGHASAVIYQP 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL22	XP_016884508.1	BTB_POZ	75..199	CDD:453885	45/123 (37%)
		PHA03098	100..640	CDD:222983	152/566 (27%)
		BACK_KLHL22	195..298	CDD:350536	24/103 (23%)
		KELCH repeat	342..383	CDD:276965	5/40 (13%)
		KELCH repeat	388..433	CDD:276965	16/59 (27%)
		KELCH repeat	437..481	CDD:276965	18/46 (39%)
		KELCH repeat	484..529	CDD:276965	10/44 (23%)
		KELCH repeat	531..579	CDD:276965	13/47 (28%)
		KELCH repeat	582..627	CDD:276965	11/44 (25%)
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	145/548 (26%)
		KELCH repeat	369..416	CDD:276965	14/47 (30%)
		KELCH repeat	420..463	CDD:276965	19/59 (32%)
		KELCH repeat	467..510	CDD:276965	10/42 (24%)
		KELCH repeat	514..558	CDD:276965	13/47 (28%)
		KELCH repeat	561..606	CDD:276965	12/46 (26%)