Protein Alignment KLHL22 and KLHL18

DIOPT Version :10

• Sequence 1: XP_016884508.1
• Gene: KLHL22 / 84861
• HGNCID: 25888
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 565
• Identity: 158/565 - (27%)
• Similarity: 258/565 - (45%)
• Gaps: 36/565 - (6%)

Human    91 LRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLI--HGVSYNAMCQIL 153
            :|..|.|.||.|.||.:...|||::|||:..||..||...:.|...:|:.:  ..:..:|:..::
  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96

Human   154 HFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQ 218
            :::|:.::.:...|||..:|.|..||:..:...|..||:|.....|:|.:...|:.....:|.:.
  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161

Human   219 LDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLH 283
            .|.||.:||...|:::::..|..|::..|:..:.|.|..|..::|..:.:....|..:::..
  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELF--- 223

Human   284 EPPKLLETVRFPLMEAEVLQRLHDKLDPSPL-------RDTVASALMYHRNESLQPSLQSPQTEL 341
              |::|..||.||:..   |.|.|::....|       ||.:..|..:|.....:..|||.:|..
  Fly   224 --PQVLAAVRLPLLSP---QFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQ 283

Human   342 RS-DFQC--VVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIG 403
            || :|..  :...||:.||..:|  ...:..:||..:|| ....::...|..|:||||..:|..|
  Fly   284 RSGEFFTGQIYAVGGLASTGESV--STVEIYDPLTKKWK-MGEQMSMMRSRVGVAVLNGKLYAFG 345

Human   404 GDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYD 468
            |.|   |....|....||||.|:|.|..::..:.:.:.|..:...||...|.|....||.||.|.
  Fly   346 GFN---GTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYY 407

Human   469 PATNSWAYVAPLKREVYAHAGAT--LEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRR 531
            |.:|:|..||.:.:  |..||..  |.|.:|...|..|.........||...:.|..::....||
  Fly   408 PKSNTWKTVAQMMK--YRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRR 470

Human   532 AWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYV 596
            ...|:|||..|:||.||...::..|    .|.||...:..|..|.|:........:|....:::.
  Fly   471 CRLGVATLNGKIYVCGGYCGNSFLR----SVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWA 531

Human   597 LGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTL 641
            :||  ::..|....|.:||.|.|.|...|.:.....|:.|.|:.:
  Fly   532 IGG--YDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL22	XP_016884508.1	BTB_POZ	75..199	CDD:453885	33/109 (30%)
		PHA03098	100..640	CDD:222983	154/553 (28%)
		BACK_KLHL22	195..298	CDD:350536	24/102 (24%)
		KELCH repeat	342..383	CDD:276965	12/43 (28%)
		KELCH repeat	388..433	CDD:276965	19/44 (43%)
		KELCH repeat	437..481	CDD:276965	15/43 (35%)
		KELCH repeat	484..529	CDD:276965	11/46 (24%)
		KELCH repeat	531..579	CDD:276965	17/47 (36%)
		KELCH repeat	582..627	CDD:276965	11/44 (25%)
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	32/104 (31%)
		PHA03098	36..510	CDD:222983	141/493 (29%)
		KELCH repeat	329..372	CDD:276965	19/45 (42%)
		KELCH repeat	376..417	CDD:276965	13/40 (33%)
		KELCH repeat	423..466	CDD:276965	10/42 (24%)
		KELCH repeat	470..514	CDD:276965	17/47 (36%)
		Kelch_1	517..560	CDD:396078	11/44 (25%)
		KELCH repeat	517..560	CDD:276965	11/44 (25%)