Protein Alignment KLHL22 and CG15097

DIOPT Version :10

• Sequence 1: XP_016884508.1
• Gene: KLHL22 / 84861
• HGNCID: 25888
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_001261079.1
• Gene: CG15097 / 37172
• FlyBaseID: FBgn0034396
• Length: 743
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 159/612 - (25%)
• Similarity: 267/612 - (43%)
• Gaps: 62/612 - (10%)

Human    62 PAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGM 126
            |..|:........:::..|..|....:..:|::..|.||.|.|.|..|.|||::||:...||..|
  Fly    36 PPGPNEEVLPQAHHQNPGHCIASFAAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAM 100

Human   127 FAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 191
            |...:.|..|..|.:|.|..:|:.|::.:.||.|:.::..|||..|.|:..||:..:...||.||
  Fly   101 FNDDMLERTQGLVRLHDVDSSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFL 165

Human   192 MSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVS 256
            :..:...|.|.:...|:......|..:...|.|:||.....|:::..||.|:|..|:|:::|.:|
  Fly   166 LRQLHPSNCLGIRSFADAHSCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNIS 230

Human   257 CETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPL---------MEAEVLQRLHDKLDPS 312
            .|..|:  |.:.::....:...::.:.|   |:..||.||         :|.|.|.|     |.|
  Fly   231 SEERVF--AAVINWVKHDLPTRRLHIAE---LMSNVRLPLVSRDFLMSCVETETLMR-----DDS 285

Human   313 PLRDTVASALMYHRNESLQPSLQSPQTELR-----SDFQCVVGFGGIHSTPSTVLSDQAKYLNPL 372
            ..::.:..|:.||.....:..:.|.:|:.|     ..:...||.|.:.:     :.::.:..||.
  Fly   286 ECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVGGGSLFA-----IHNECEVYNPR 345

Human   373 LGEWKHFTASLAP---RMSNQGIAVLNNFVYLIGGDNNVQGF-RAESRCWRYDPRHNRWFQIQSL 433
            ...|    :.:||   |.|..|:..|:..:|::||.:.|... .|||    |:|..|:|..|..:
  Fly   346 SNSW----SPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAES----YNPLTNKWSNITPM 402

Human   434 QQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLK-REVYAHAGATLEGKMY 497
            ..:.:.|.:|.....||...|.|..:.|:::|||||.|..|:....:. |..|... |.||..:|
  Fly   403 GTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRL-AVLENCIY 466

Human   498 ITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNN----DAGYRRD 558
            ...|....:|......:||....|..:.....||:..|:|:....||.|||::.    .:|.|
  Fly   467 SLGGFDSTNYQSSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTMCMSSGER-- 529

Human   559 VHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRT-GYVHIYDVEKDCWE 622
                  :|.....|..:..:.:......:..::..::.|||   |.||.: ..|..||...:.|.
  Fly   530 ------FSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGG---NDGSSSLNSVERYDTRLNKWS 585

Human   623 EGPQLDNSISGLAACVLT---LPRSLL 646
            ....:....|.:.|.||.   |.|.|:
  Fly   586 VVNAMVARRSSVGAAVLECFHLERGLV 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL22	XP_016884508.1	BTB_POZ	75..199	CDD:453885	40/123 (33%)
		PHA03098	100..640	CDD:222983	148/563 (26%)
		BACK_KLHL22	195..298	CDD:350536	26/111 (23%)
		KELCH repeat	342..383	CDD:276965	7/45 (16%)
		KELCH repeat	388..433	CDD:276965	15/45 (33%)
		KELCH repeat	437..481	CDD:276965	14/43 (33%)
		KELCH repeat	484..529	CDD:276965	10/44 (23%)
		KELCH repeat	531..579	CDD:276965	12/51 (24%)
		KELCH repeat	582..627	CDD:276965	10/45 (22%)
CG15097	NP_001261079.1	BTB_POZ	51..171	CDD:453885	40/119 (34%)
		PHA03098	65..539	CDD:222983	138/505 (27%)
		BACK	169..282	CDD:475122	29/117 (25%)
		KELCH repeat	359..402	CDD:276965	15/46 (33%)
		KELCH repeat	406..450	CDD:276965	14/43 (33%)
		KELCH repeat	453..496	CDD:276965	10/43 (23%)
		KELCH repeat	500..545	CDD:276965	12/52 (23%)
		KELCH repeat	547..590	CDD:276965	10/45 (22%)
		Kelch	559..603	CDD:128874	13/46 (28%)