Protein Alignment KLHL22 and CG9426

DIOPT Version :10

• Sequence 1: XP_016884508.1
• Gene: KLHL22 / 84861
• HGNCID: 25888
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_609616.1
• Gene: CG9426 / 34719
• FlyBaseID: FBgn0032485
• Length: 627
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 163/590 - (27%)
• Similarity: 269/590 - (45%)
• Gaps: 45/590 - (7%)

Human    74 TYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAG--GLKEMEQ 136
            :|.:||:...:|..|..||:.....||.::.....:.|||.:|:|:..||..||..  ||.|::|
  Fly    59 SYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQ 123

Human   137 EEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENIL 201
            :.|::|.:..:.:..:|.||||...|::.|||||.|.||..||:.|::..||:||...:...|.|
  Fly   124 KSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNAL 188

Human   202 DVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGAL 266
            .:.|.||..:...|.:....::..||.|.:..|::.:.|...:..||:|..|.|..|::|::.||
  Fly   189 GILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAAL 253

Human   267 LYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPLRD-TVASAL------MY 324
              .:....|...:..:.:   :|..||..|:..:|:    ||......|| :|..||      :.
  Fly   254 --RWIKHDVTQRRCYVFD---VLSHVRMALVPVKVI----DKALKDDCRDMSVKIALRSICRDIA 309

Human   325 HRNESLQPSLQSPQTELRSDFQCVVGFGGIH-STPST------VLSDQAKYLNPLLGEWKHFTAS 382
            .:...|.|....|:...:.:...:   ||.| .||.|      :....||: :....||.. ||.
  Fly   310 SKRGQLVPLRVCPRQLAKKNIYII---GGSHRDTPRTWNSADCIFETVAKF-DIFRREWTE-TAP 369

Human   383 LAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGR 447
            :.......|::.||..:|::||:...| ..|....  |||:::.|..|..:.....:..:|.:|.
  Fly   370 MEVGRILPGVSALNGKIYVVGGERGSQ-ILANGEV--YDPQNDVWQPIAPMIVPRCEFGLCTMGG 431

Human   448 YIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCG-RRGEDYLKET 511
            .::||.|....:...::|.|||..:.|..:..:.:..::....:.||.:||..| .....:|.:.
  Fly   432 NLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDL 496

Human   512 HCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDV-HQVACYSCTSGQWSSV 575
            ..::|.:..|:.||.....|...|:|.|...|||:|||:    ..:|: ..|..||....:|::|
  Fly   497 ISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSS----ISQDILSSVERYSFDEDKWTTV 557

Human   576 CPLPAGHGEPGIAVLDNRIYVLGGR-----SHNRGSRT-GYVHIYDVEKDCWEEGPQLDNSISGL 634
            |.|......|.:...|..:||.||.     :..|...| ..|..||...|.|:..|.|..|.|..
  Fly   558 CALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEA 622

Human   635 AACVL 639
            .|.|:
  Fly   623 GAVVV 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL22	XP_016884508.1	BTB_POZ	75..199	CDD:453885	45/125 (36%)
		PHA03098	100..640	CDD:222983	155/564 (27%)
		BACK_KLHL22	195..298	CDD:350536	25/102 (25%)
		KELCH repeat	342..383	CDD:276965	12/47 (26%)
		KELCH repeat	388..433	CDD:276965	13/44 (30%)
		KELCH repeat	437..481	CDD:276965	10/43 (23%)
		KELCH repeat	484..529	CDD:276965	10/45 (22%)
		KELCH repeat	531..579	CDD:276965	17/48 (35%)
		KELCH repeat	582..627	CDD:276965	14/50 (28%)
CG9426	NP_609616.1	BTB_POZ_KLHL27_IPP	63..189	CDD:349565	45/125 (36%)
		PHA03098	78..558	CDD:222983	134/500 (27%)
		KELCH repeat	374..417	CDD:276965	13/45 (29%)
		KELCH repeat	421..465	CDD:276965	10/43 (23%)
		KELCH repeat	468..512	CDD:276965	10/43 (23%)
		KELCH repeat	516..561	CDD:276965	17/48 (35%)
		KELCH repeat	564..617	CDD:276965	15/52 (29%)
		Kelch	575..627	CDD:128874	16/51 (31%)