Protein Alignment KLHL22 and klhl10

DIOPT Version :10

• Sequence 1: XP_016884508.1
• Gene: KLHL22 / 84861
• HGNCID: 25888
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 151/600 - (25%)
• Similarity: 243/600 - (40%)
• Gaps: 79/600 - (13%)

Human    81 SQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAG----------GLKEME 135
            |...|..|..||:..:|.|..:.|.......||.::.:...|||..|.|          | .:.:
  Fly    65 SDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDG-SDAK 128

Human   136 QEEVLIH--GVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEE 198
            :....||  |||...|..::.:.|..:..:|.|||.|.|:.|..:.:..::..|.|:|...:..|
  Fly   129 KNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPE 193

Human   199 NILDVYRLAELFDLSRLTEQLDTYILKNF--VAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEV 261
            |.:.:...|....|..|..:...|.|:.|  ||:...| ...:..|..||::|.:.|....|..|
  Fly   194 NCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNID-ILDMSAEDFYSIISDDELNTREEDHV 257

Human   262 YEGALLY---------HYSLEQVQADQISLHEPPKLLETVR-FP-LMEAEVLQRLHDKLDPSPLR 315
            ::..:.:         .:....:...::.|..|...:|.|: .| ::|.|..:.|        :.
  Fly   258 WKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPL--------IV 314

Human   316 DTVASALMY-------HRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLL 373
            ||.  ..||       ..:|...|.|..|    |...:.:...||.....|   ....:..:...
  Fly   315 DTF--KFMYDLDFLNPQADELTTPPLAMP----RLPHEVIFAIGGWSGGTS---KGCIETYDTRA 370

Human   374 GEWKHFTAS--LAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQE 436
            ..|....|.  ..|| :..|.|||...::.|||.:.|:.|   :.|..:|....:|.:|..:...
  Fly   371 DRWVTINAEDPAGPR-AYHGTAVLGFKIFSIGGYDGVEYF---NTCRVFDAVKKKWNEIAPMHCR 431

Human   437 HADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCG 501
            ...:||..:...|||:.|.|.||.||.||||:|.||.|:.:.|:..:....:..||:.::|.|.|
  Fly   432 RCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGG 496

Human   502 RRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDA----GYRRDVHQV 562
            ..|::.|.....|||.:|.|..:.:...||:........|:||||||.|..|    |.|.|.
  Fly   497 FNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDP--- 558

Human   563 ACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQL 627
                 .:..|..:..:.......|:.::|:.|:.:||  .|..|...:...|..|.|.|.|...:
  Fly   559 -----DTQTWHFIREMNHSRSNFGLEIIDDMIFAIGG--FNGVSTISHTECYVAETDEWMEATDM 616

Human   628 D--------NSISGL 634
            :        |:|:||
  Fly   617 NIVRSALSANNIAGL 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL22	XP_016884508.1	BTB_POZ	75..199	CDD:453885	33/129 (26%)
		PHA03098	100..640	CDD:222983	143/580 (25%)
		BACK_KLHL22	195..298	CDD:350536	23/115 (20%)
		KELCH repeat	342..383	CDD:276965	6/42 (14%)
		KELCH repeat	388..433	CDD:276965	13/44 (30%)
		KELCH repeat	437..481	CDD:276965	20/43 (47%)
		KELCH repeat	484..529	CDD:276965	12/44 (27%)
		KELCH repeat	531..579	CDD:276965	14/51 (27%)
		KELCH repeat	582..627	CDD:276965	12/44 (27%)
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	11/42 (26%)
		PHA03098	86..610	CDD:222983	138/556 (25%)
		KELCH repeat	385..428	CDD:276965	14/46 (30%)
		KELCH repeat	432..475	CDD:276965	19/42 (45%)
		KELCH repeat	479..523	CDD:276965	12/43 (28%)
		KELCH repeat	526..571	CDD:276965	14/52 (27%)
		KELCH repeat	573..617	CDD:276965	12/45 (27%)