Protein Alignment KLHL22 and CG1812

DIOPT Version :10

• Sequence 1: XP_016884508.1
• Gene: KLHL22 / 84861
• HGNCID: 25888
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_608397.1
• Gene: CG1812 / 33049
• FlyBaseID: FBgn0031119
• Length: 616
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 172/607 - (28%)
• Similarity: 288/607 - (47%)
• Gaps: 75/607 - (12%)

Human    60 KLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFR 124
            |:|..|..|           ..:.|||||..||:...|.||.|:||....:|||::||||.|||.
  Fly    21 KIPVNPVSP-----------EEETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFC 74

Human   125 GMFAG-GLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCC 188
            .|||. .:.|..::|:.::|:...||..|:.:||||.|||:..|::|.|.||..:|:.|:|..|.
  Fly    75 AMFADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCT 139

Human   189 DFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSN-R 252
            .||.:.::.||.|.:..:|:::.:..|:|:...|:..:|..|:.|..::::.::::..:|||| .
  Fly   140 IFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYP 204

Human   253 LEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLD------- 310
            ::|:.:..|   .|:..:::|| |.::.:|.:..:|::.........:.|:.::..||
  Fly   205 IDVAEQDLV---RLVCSFAIEQ-QLNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPL 265

Human   311 PSPLRDTVASALMYH--------RNESLQPSLQSPQTELRSDFQCVVGFGGI--HSTPSTVLSDQ 365
            |:...:.:....|.|        :::||.   |.| |.:|....|::..||.  :...:.::...
  Fly   266 PTSYYNRIKQEHMGHLLNGVVSLKDQSLP---QGP-TNMRGMELCLLKIGGFEWNGLTNVIMCFS 326

Human   366 AKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNV--------QGFRAESRCWRYDP 422
            .|.:|     |...||.......|.|.|||||.::::||..:|        .||     |  |.|
  Fly   327 PKKMN-----WYELTAIPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFGF-----C--YCP 379

Human   423 RHNRWFQIQSLQQEHADLSVCVVG-RYIYAVAG-RDYHND-----LNAVERYDPATNSWAYVAPL 480
            ..|.|..|..:||:....|:..|| :::|||.| .|..|:     ::.|||||.|.|.|.|:..|
  Fly   380 LRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSL 444

Human   481 KREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYV 545
            :.....|||..:..|:||:.|....:.|.....:|..:..|..||..|.....|.:..:.|::|.
  Fly   445 QENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYA 509

Human   546 IGGSNND-AGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGG----RSHNRG 605
            .||.:.. ..:|..|..:..|...:..||....:||.....|:..:...|:.:||    .|.:|.
  Fly   510 CGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRA 574

Human   606 SRTGYVHIYDV-----EKDCWE 622
            |.....:..|.     |||.|:
  Fly   575 SAETMAYDLDTKEWWHEKDSWD 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL22	XP_016884508.1	BTB_POZ	75..199	CDD:453885	50/124 (40%)
		PHA03098	100..640	CDD:222983	159/567 (28%)
		BACK_KLHL22	195..298	CDD:350536	22/103 (21%)
		KELCH repeat	342..383	CDD:276965	9/42 (21%)
		KELCH repeat	388..433	CDD:276965	18/52 (35%)
		KELCH repeat	437..481	CDD:276965	18/50 (36%)
		KELCH repeat	484..529	CDD:276965	12/44 (27%)
		KELCH repeat	531..579	CDD:276965	10/48 (21%)
		KELCH repeat	582..627	CDD:276965	12/50 (24%)
CG1812	NP_608397.1	BTB_POZ	33..151	CDD:453885	51/117 (44%)
		PHA03098	46..588	CDD:222983	157/561 (28%)
		KELCH repeat	344..390	CDD:276965	18/52 (35%)
		KELCH repeat	394..444	CDD:276965	18/49 (37%)
		KELCH repeat	448..492	CDD:276965	12/43 (28%)
		KELCH repeat	495..539	CDD:276965	9/43 (21%)