Protein Alignment KLHL22 and CG17754

DIOPT Version :10

• Sequence 1: XP_016884508.1
• Gene: KLHL22 / 84861
• HGNCID: 25888
• Length: 682
• Species: Homo sapiens
• Sequence 2: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Alignment Length: 620
• Identity: 175/620 - (28%)
• Similarity: 285/620 - (45%)
• Gaps: 74/620 - (11%)

Human    75 YRSAQHSQALLRGLLALRDSGILFDVVLV--VEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQE 137
            :|...|:..:|:.:....||..|.||||:  ::|:.:.|||::|:||..||..||.|.|:|.:::
  Fly    52 FRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQ 116

Human   138 EVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILD 202
            ||.:..|..:|:..::.:.||..:|:....|:..|..||.||:..::..||:||...:...|.|.
  Fly   117 EVTLGEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLG 181

Human   203 VYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALL 267
            ....||....:.|......|..:.|:...:..::.||..:::..||||:.|.|..|.:|
  Fly   182 FAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDV------ 240

Human   268 YHYSLEQVQADQISLHEP-PKLLETVRFPLME-AEVLQRLHDKLDPSPLRDTVASALMYHRNESL 330
            :|..:..|:.|..:..:. |:||..||.||:: |.::..:.:..:.:..:..|..|..:|    |
  Fly   241 FHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVENVCNANECQQLVMEAFKWH----L 301

Human   331 QPSLQSP-QTELRSDFQCVVG----FGGIHSTPSTVLSDQAKYLNPLLGE---WKHFTASLAPRM 387
            .|..:|. .||..:..:..||    .||:.:....:..:  .|. |.|.:   |||.|.    |.
  Fly   302 MPERRSRIATERTTPRKSTVGRLLAVGGMDAHKGAISIE--SYC-PRLDKWTPWKHMTG----RR 359

Human   388 SNQGIAVLNNFVYLIGGD------NNVQGFRAESRCW-----RYDPRHNRWFQIQSLQQEHADLS 441
            ...|.||:.:.:.|:||.      |.|:.....:..|     ...|||.              |.
  Fly   360 LQFGAAVMEDKLILVGGRDGLKTLNTVESLDLNTMAWAPLNAMATPRHG--------------LG 410

Human   442 VCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAG-ATLEGKMYITCGRRGE 505
            |.|:...:|||.|.|..:.||.|||:||...:|:||||:. .:.:.|| |.|.|::|...||.|.
  Fly   411 VAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMS-SMRSTAGVAVLGGRLYAVGGRDGS 474

Human   506 DYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGG----SNNDAGYRRDVHQVACYS 566
            ...:...||||.:|.|..||....||...|:......||.:||    ::|....|.:.  |..|.
  Fly   475 VCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTET--VERYD 537

Human   567 CTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSI 631
            ..:..|:.:|.|..|....|.|:|.:|:.|:||...|...::  |..||..::.|.|...:..:.
  Fly   538 PATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKS--VEEYDPVRNGWNELAPMAFAR 600

Human   632 SGLAACVLTLPRSLLLEPPRGTPDRSQADPDFASE 666
            :|  |||:.:|..:        |..:|..|..|::
  Fly   601 AG--ACVVAIPNVI--------PPAAQQPPPSATK 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL22	XP_016884508.1	BTB_POZ	75..199	CDD:453885	41/125 (33%)
		PHA03098	100..640	CDD:222983	163/567 (29%)
		BACK_KLHL22	195..298	CDD:350536	27/103 (26%)
		KELCH repeat	342..383	CDD:276965	11/47 (23%)
		KELCH repeat	388..433	CDD:276965	12/55 (22%)
		KELCH repeat	437..481	CDD:276965	20/43 (47%)
		KELCH repeat	484..529	CDD:276965	17/45 (38%)
		KELCH repeat	531..579	CDD:276965	12/51 (24%)
		KELCH repeat	582..627	CDD:276965	13/44 (30%)
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	160/555 (29%)
		KELCH repeat	359..402	CDD:276965	9/42 (21%)
		KELCH repeat	406..449	CDD:276965	21/56 (38%)
		KELCH repeat	453..497	CDD:276965	17/43 (40%)
		KELCH repeat	500..549	CDD:276965	12/50 (24%)
		KELCH repeat	553..596	CDD:276965	13/44 (30%)