DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FCRLA and bdl

DIOPT Version :9

Sequence 1:	NP_001171795.2	Gene:	FCRLA / 84824	HGNCID:	18504	Length:	365	Species:	Homo sapiens
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	243	Identity:	61/243 - (25%)
Similarity:	87/243 - (35%)	Gaps:	44/243 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    77 FHLIVSYDWLILQGPA-KPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALGP---------PGPN 131
            :||.|....||...|. :.:.||......| ..:....:|.::|:||..|..         .||:
  Fly   143 YHLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPD 206

Human   132 REFSITVVQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSAEPQAGSPMTL 196
            ...||.....:|.|.|.|. :..|.|.  .:||... :.:|  :.|.::.|.|......|.|..|
  Fly   207 GSLSIDPTMMSDLGEYECK-VRNSDGE--LQTAKAF-LNIQ--YKAKVIYAPPEVFLPYGQPAVL 265

Human   197 SCQTKL--PLQRSAARLLFSFYKDGRIVQSRGLSSEFQIPTAS-------EDHSGSYWCEAATED 252
            .|..:.  ||:.      ..:.|||.:..|..:...|.....|       |:|:|||.|   |..
  Fly   266 DCHFRANPPLKN------LRWEKDGLLFDSYNVPGVFYKMNGSLFFAKVDENHAGSYTC---TPY 321

Human   253 NQVWKQSPQLEIRVQGASSSAAPPTLNPAP-----QKSAAPGTAPEEA 295
            |.:....|...|.|    ....||..:..|     ||.......|.||
  Fly   322 NDLGTDGPSPVISV----IVLRPPIFSVTPKAIYIQKLGEAAELPCEA 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRLA	NP_001171795.2	Ig	85..152	CDD:353325	19/76 (25%)
		Ig_2	177..266	CDD:316418	25/97 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..319		9/36 (25%)
bdl	NP_608822.1	IG_like	42..128	CDD:214653
		Ig	43..131	CDD:299845
		I-set	153..242	CDD:254352	22/93 (24%)
		Ig	157..242	CDD:299845	21/89 (24%)
		Ig_2	252..337	CDD:290606	24/97 (25%)
		IG_like	260..327	CDD:214653	20/75 (27%)
		I-set	341..428	CDD:254352	7/25 (28%)
		IGc2	356..419	CDD:197706	3/10 (30%)
		FN3	435..524	CDD:238020
		FN3	554..636	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910