Protein Alignment LMNB2 and Lam

DIOPT Version :10

• Sequence 1: NP_116126.3
• Gene: LMNB2 / 84823
• HGNCID: 6638
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_476616.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 644
• Identity: 232/644 - (36%)
• Similarity: 367/644 - (56%)
• Gaps: 62/644 - (9%)

Human    14 RPRAAATMATPLPGRAGGP-------------------ATPLSPTRLSRLQEKEELRELNDRLAH 59
            :.|.|.| |||.||....|                   ::||||||.||:.||.||:.||||||.
  Fly     4 KSRRAGT-ATPQPGNTSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLAT 67

Human    60 YIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKL 124
            ||||||.||.||.||.:::....:..|||.:.||.::|:||.:.||:||:|||:|||.:|:|.:|
  Fly    68 YIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRL 132

Human   125 RAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAED 189
            ..|.:|:.....|:..|.|.|:|.|:..||..:....:...|.:|::.|..|:.|...:|.:...
  Fly   133 WEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRK 197

Human   190 GHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDF 254
            .....:|.||:|||.||||||..|||:|||.|:..:..:|:.|:||..:....|:|.....|||.
  Fly   198 QFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDA 262

Human   255 KMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSY 319
            |:.|:|:|||:|::||:::.:.|::..|:.|:...:.::.:...:...:.|||:..|:|:::|:.
  Fly   263 KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNA 327

Human   320 QLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLAL 384
            .::.|::..:....|||:||..:..:|::..:.:|..|:|:..:|:.|.|||.|||:|:|:|::|
  Fly   328 NINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSL 392

Human   385 DMEINAYRKLLEGEEERLKLSPSP--------------SSRVTVSRATSSSSGSLSATGRLGRSK 435
            |:||.||.|||.|||.||.::|:.              |:|.|.||.|.|::           .|
  Fly   393 DLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAA-----------VK 446

Human   436 RKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGN 500
            |||..|:|  ....||        ..::::  |||.|:|.|:|||.|||||:|.|...::.::|.
  Fly   447 RKRAVVDE--SEDHSV--------ADYYVS--ASAKGNVEIKEIDPEGKFVRLFNKGSEEVAIGG 499

Human   501 WRIKRQVLE-GEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVL 564
            |:::|.:.| |....|||.....:....::|||:|....:|.|||:||.|.| .|.:.::.||:|
  Fly   500 WQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQ-KWVSADNTRTIL 563

Human   565 VNADGEEVA-MRTVKK--SSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM 620
            :|::||.|| :..:|:  |.....:.........|..|.|.|:||||||:.::..|.:|
  Fly   564 LNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAVDGNEQLYHQQGDPQQSNEKCAIM 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LMNB2	NP_116126.3	Head	1..48		18/52 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		11/42 (26%)
		Filament	45..401	CDD:459643	138/355 (39%)
		Coil 1A	49..83		20/33 (61%)
		Linker 1	84..95		5/10 (50%)
		Coil 1B	96..229		51/132 (39%)
		Linker 2	230..256		8/25 (32%)
		Coil 2	257..400		49/142 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..464		19/78 (24%)
		Tail	401..620		76/236 (32%)
		Nuclear localization signal. /evidence=ECO:0000255	435..440		4/4 (100%)
		LTD	468..576	CDD:460003	45/109 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	581..620		11/38 (29%)
Lam	NP_476616.1	Filament	54..409	CDD:459643	138/354 (39%)
		LTD	467..572	CDD:460003	43/105 (41%)