DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SEMA7A and Sema1a

DIOPT Version :9

Sequence 1:	NP_003603.1	Gene:	SEMA7A / 8482	HGNCID:	10741	Length:	666	Species:	Homo sapiens
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	174/708 - (24%)
Similarity:	294/708 - (41%)	Gaps:	151/708 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    31 LRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVG-QDRVDFGQTE---PHTVLFHEPGSSSVWVGG 91
            |.|.:|:....::.|.::|  |:::.    .:| :|.:.|...|   .|..|..:.| :|:.:|.
  Fly    54 LLLTVLVIGNQSAWQENIR--PKLYV----ELGPEDVLKFVGNESVVDHFKLVTKDG-NSLLIGA 111

Human    92 RGKVY---LFDFPEGKNASVRTVNIGSTKGSCL----DKRDCENYITLLERRSEG-LLACGTNAR 148
            |..|:   :.|..| :...|.|.....|| .||    |:..|:|||.::...|.| |..||||:.
  Fly   112 RNTVFNLSIHDLVE-QQRLVWTSPEDDTK-MCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSF 174

Human   149 HPSCWNLV----NGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYS-TIRKQEYNGKIPRFRRIRG 208
            .|.|...:    |.|:......:...|:.|..||..:...:|:|| |:  .:::|..|...|...
  Fly   175 RPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTV--ADFSGSDPIIYREPL 237

Human   209 ESELYTSDTVMQN-PQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGG 272
            ::|.|  |::..| |.|:.:.      ...|.:|:||||...:.........||||::|:.|:||
  Fly   238 QTEQY--DSLSLNAPNFVSSF------TQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGG 294

Human   273 ESSLSVSKWNTFLKAMLVCSDAATNK-NFNRLQDVF-LLPDPSGQWRDTRVYGVFSNPWNY---S 332
            ..... ::|.:|||:.|.||...... .||.:|... |:....|......:||||:.|.|.   |
  Fly   295 PHRFR-NRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGS 358

Human   333 AVCVYSLGDIDKVF----------RTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEV 387
            |||.::|.||...|          .::.|...::.:|:||||.|..|.:.:|..|......|..:
  Fly   359 AVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDPTLNFIKTHSLM 423

Human   388 AQRVEPMGPLKTPLFHSK---------YHYQKVAVH-RMQASHGETFHVLYLTTDRGTIHKVV-- 440
            .:.|        |.|.|:         |.:.::||. :::...|:|:.|:::.||.|.|.|.|
  Fly   424 DENV--------PAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNA 480

Human   441 ---EPGEQEHSFAFNIMEI----QPFRRAAAIQTMSLDAER------RKLYVSSQWEVSQVPLDL 492
               :..::..|.....:::    :|.|....::||..|..:      .||.:.:..:|..:.|..
  Fly   481 ESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHR 545

Human   493 C---EVYGGGCHGCLMSRDPYCGWDQ--GRCIS----IYSSERSVLQSINPAEPHKECP----NP 544
            |   ::  ..|..|:..:||||.||:  |:|.|    .:..|....|::...: |..||    |.
  Fly   546 CHNDKI--TSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQ-HAACPSGKINS 607

Human   545 KPDKAPLQK-----VSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCI------- 597
            |...|..||     :.|           ::||..:......:|::::.|....|.:.|
  Fly   608 KDANAGEQKGFRNDMDL-----------LDSRRQSKDQEIIDNIDKNFEGPQISADIINAQYTVE 661

Human   598 ----------LFIENLTAQQYGHYFCEAQ--------------EGSYFREAQHWQLLP 631
                      :|  :|....:..|||..:              |..||.:.|:....|
  Fly   662 TLVMAVLAGSIF--SLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFP 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SEMA7A	NP_003603.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Sema_7A	72..491	CDD:200504	125/475 (26%)
		Cell attachment site. /evidence=ECO:0000255	267..269		0/1 (0%)
		Interaction with integrins	267..269		0/1 (0%)
		PSI	493..>527	CDD:307546	13/42 (31%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	126/476 (26%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/35 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910