DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF577 and LOC101731232

DIOPT Version :9

Sequence 1:	NP_001357376.1	Gene:	ZNF577 / 84765	HGNCID:	28673	Length:	485	Species:	Homo sapiens
Sequence 2:	XP_004919616.1	Gene:	LOC101731232 / 101731232	-ID:	-	Length:	1375	Species:	Xenopus tropicalis

Alignment Length:	517	Identity:	168/517 - (32%)
Similarity:	243/517 - (47%)	Gaps:	149/517 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    24 SFEDVAVGFTREEWQFLDQSQKVLYKEVMLENYINLVSIGYRGTKPDSLFKLEQGE--------- 79
            :|:||||.|:..||:.|..||:.:||.||.|||..::|:||...||:.:.|:|.||
Frog    13 TFDDVAVYFSWSEWESLSPSQRDMYKSVMAENYECVLSLGYPIGKPEIVSKIEAGEDLWSRSDAR 77

Human    80 --------------------------------------PPGIAEG---AAHSQICPGFVIQSRRY 103
                                                  ...:.||   |..|.||        .:
Frog    78 PERKEKDGETPKDSDWAAEDYKEVLYLGTLAAVKSEPVEEPVVEGSNSAKKSHIC--------SH 134

Human   104 AGKDSDAFGGYGR-----------SCLH-----------IKRDKTLTGVKYHRCV---KPSSPKS 143
            .||....:....|           .|.|           ||..:|.||.:.::|.   |..:.:|
Frog   135 CGKLFSCYAAAARHQRMHRLQKAHQCPHCKKGFVQKSDLIKHHRTHTGERPYQCAECQKNFTERS 199

Human   144 QLNDLQKICAGGKPHECSVCGRAFSRKAQLIQHQRTERGEKPHGCGECGKTFMRKIQLTEHQRTH 208
            .|.:.|:...|.:|:.|..|.::|::::.|.:|:||..||:|:.|..|.|:|::...|.:|.|||
Frog   200 ALVNHQRTHTGERPYRCPDCLKSFNQRSALTKHRRTHTGERPYHCSVCAKSFIQNSDLVKHVRTH 264

Human   209 TGEKPHECSECGKAFSRKSQLMVHQRTHTGEKPYRCSKCGKAFSR-------------------- 253
            |||||:||..|||.|:..|.||.|:|||..::|:|||:|.::|::
Frog   265 TGEKPYECPLCGKRFAESSALMKHKRTHNAQRPFRCSECSRSFAQNSDLAAHMRKHTESQNVPDP 329

Human   254 --------------------------KCR--------LNRHQRSHTGEKLYGCSVCGKAFSQKAY 284
                                      |||        |..||::|.|||.|.||.|.|.|.|.:.
Frog   330 DSVVGTGPLSSQNEVITAAESPFSCAKCRKTFKQWTSLLNHQQAHCGEKPYLCSYCNKGFVQNSD 394

Human   285 LTAHQRLHTGDKPYKCSDCGRTFYFKSDLTRHQRIHTGEKPYECSECEKAFRSKSKLIQHQRTHT 349
            |..|.|.|||::||:|:||.:.|..||||.:|.|.||||||::|:.|:|.|..||.|.:||||||
Frog   395 LVKHLRTHTGERPYQCADCHKGFIQKSDLVKHLRTHTGEKPFKCTHCDKKFTEKSALAKHQRTHT 459

Human   350 GERPYSCRECGKAFAHMSVLIKHEKTHIRETAINSLTVEKP---SSRSHTSLYMSELIQEQK 408
            ||:||.|..|.|||...|.||.|::.|         |.|:|   ::...:.:..|:|::.||
Frog   460 GEKPYKCSTCEKAFTQRSNLILHQRIH---------TGERPYKCTTCLRSFIQNSDLVKHQK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF577	NP_001357376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		KRAB	25..83	CDD:214630	27/104 (26%)
		COG5048	136..>217	CDD:227381	31/83 (37%)
		C2H2 Zn finger	160..180	CDD:275368	6/19 (32%)
		C2H2 Zn finger	188..208	CDD:275368	7/19 (37%)
		COG5048	<194..399	CDD:227381	101/261 (39%)
		C2H2 Zn finger	216..236	CDD:275368	10/19 (53%)
		C2H2 Zn finger	244..264	CDD:275368	10/73 (14%)
		C2H2 Zn finger	272..292	CDD:275368	9/19 (47%)
		C2H2 Zn finger	300..320	CDD:275368	10/19 (53%)
		C2H2 Zn finger	328..348	CDD:275368	10/19 (53%)
		C2H2 Zn finger	356..376	CDD:275368	9/19 (47%)
LOC101731232	XP_004919616.1	KRAB	13..72	CDD:214630	27/58 (47%)
		KRAB	13..51	CDD:279668	18/37 (49%)
		COG5048	<128..290	CDD:227381	54/169 (32%)
		C2H2 Zn finger	132..152	CDD:275368	4/27 (15%)
		C2H2 Zn finger	160..180	CDD:275368	4/19 (21%)
		C2H2 Zn finger	188..208	CDD:275368	5/19 (26%)
		zf-H2C2_2	200..225	CDD:290200	7/24 (29%)
		COG5048	212..604	CDD:227381	119/310 (38%)
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		zf-H2C2_2	228..253	CDD:290200	11/24 (46%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		zf-H2C2_2	256..280	CDD:290200	15/23 (65%)
		C2H2 Zn finger	272..292	CDD:275368	10/19 (53%)
		C2H2 Zn finger	300..320	CDD:275368	4/19 (21%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		C2H2 Zn finger	382..402	CDD:275368	9/19 (47%)
		C2H2 Zn finger	410..430	CDD:275368	10/19 (53%)
		zf-H2C2_2	422..446	CDD:290200	13/23 (57%)
		C2H2 Zn finger	438..458	CDD:275368	10/19 (53%)
		zf-H2C2_2	450..475	CDD:290200	16/24 (67%)
		COG5048	462..828	CDD:227381	19/60 (32%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..514	CDD:275368	4/19 (21%)
		C2H2 Zn finger	533..553	CDD:275368
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		C2H2 Zn finger	616..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		zf-H2C2_2	656..681	CDD:290200
		C2H2 Zn finger	672..692	CDD:275368
		zf-H2C2_2	684..708	CDD:290200
		C2H2 Zn finger	700..720	CDD:275368
		zf-H2C2_2	712..737	CDD:290200
		C2H2 Zn finger	728..748	CDD:275368
		C2H2 Zn finger	782..802	CDD:275368
		C2H2 Zn finger	810..830	CDD:275368
		zf-H2C2_2	822..847	CDD:290200
		C2H2 Zn finger	838..858	CDD:275368
		zf-H2C2_2	850..875	CDD:290200
		C2H2 Zn finger	866..886	CDD:275368
		zf-H2C2_2	878..903	CDD:290200
		COG5048	890..1315	CDD:227381
		C2H2 Zn finger	894..914	CDD:275368
		zf-H2C2_2	906..930	CDD:290200
		C2H2 Zn finger	922..942	CDD:275368
		C2H2 Zn finger	950..970	CDD:275368
		C2H2 Zn finger	1021..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1077..1097	CDD:275368
		C2H2 Zn finger	1166..1186	CDD:275368
		C2H2 Zn finger	1194..1214	CDD:275368
		zf-H2C2_2	1206..1231	CDD:290200
		C2H2 Zn finger	1222..1242	CDD:275368
		zf-H2C2_2	1234..1257	CDD:290200
		C2H2 Zn finger	1250..1270	CDD:275368
		zf-H2C2_2	1265..1287	CDD:290200
		C2H2 Zn finger	1278..1298	CDD:275368
		C2H2 Zn finger	1306..1325	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I41309
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910