Protein Alignment CDC42BPA and ROM1

DIOPT Version :10

• Sequence 1: NP_001374479.1
• Gene: CDC42BPA / 8476
• HGNCID: 1737
• Length: 1845
• Species: Homo sapiens
• Sequence 2: NP_011584.2
• Gene: ROM1 / 852961
• SGDID: S000003302
• Length: 1155
• Species: Saccharomyces cerevisiae
• Alignment Length: 1345
• Identity: 245/1345 - (18%)
• Similarity: 435/1345 - (32%)
• Gaps: 468/1345 - (34%)

Human   353 NCEAPYIPEVSSPTDTSNFDVDDDCLKNS--------ETMPPPT----------HTAFSGHHLPF 399
            |...|::.:.|||:..| |.      |||        :...|||          |::|:|.|
Yeast   144 NVLLPHVRKHSSPSLLS-FS------KNSGSHMGDPNQLSTPPTPKSAGHTMELHSSFNGKH--- 198

Human   400 VGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQE 464
                  ||...|....|.          .:..|....:|.:..:.:.| :...|.:...||   .
Yeast   199 ------SSSSTSSLFALE----------SLKTQNRRSSNSSNHSSQYR-RHTNQHQRHHSR---S 243

Human   465 STQTVQALQYSTVDG-PLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQL--EEANAVRQELDDA 526
            .:..|...:.|.:.| ||.....|.:..:     |.::.:..|:|.:..|  .::...:|.:|..
Yeast   244 KSSPVSLTEISMIKGTPLVYPALLSLIAI-----KFKQTIKLSTHKKMGLLYRDSFTGKQAIDTL 303

Human   527 FRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHT 591
            ...|.:.::.:..|      :.|.|
Yeast   304 CLIIGSLDRNLGML------IGKSL---------------------------------------- 322

Human   592 QKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYS 656
            :.|||...|.......|.|::..|...:.:....:::....: ....::.:|....||.::|.|
Yeast   323 EAQKLFHDVLYDHGVRDSVLEIYELSSESIFMAHQSQSSTSI-ANTFSSSSSSVNSLRTKTEIY- 385

Human   657 KQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKE 721
                    |:...........||:|      ||     ..||.....|.::..:|......||:.
Yeast   386 --------GVFVPLTHCYSSTCSLE------KL-----CYSISCPNRLQQQANLHLKLGGGLKRN 431

Human   722 LHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKV---LLTEENKKLTSEL 783
            :      .|||:||     |. |:....:...:..:||..|||.:|::.   |.|.| ||....|
Yeast   432 I------SLALDKE-----DD-ERISWTNSVPKSVWESLSKQQIKRQEAIYELFTTE-KKFVKSL 483

Human   784 DKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEE 848
            :.:...:....:....:..:|     :...|.|..|.|.||.. |:     |.:|:|||.:.:..
Yeast   484 EIIRDTFMKKLLETNIIPSDV-----RINFVKHVFAHINEIYS-VN-----REFLKALAQRQSLS 537

Human   849 ----------LEAL---------------RNSSLGTRATDMPWKMRRFAKLD-----MSARLELQ 883
                      |:.|               ....:.|:.:..|    .||:.|     .|.|..:.
Yeast   538 PICPGIADIFLQYLPFFDPFLSYIASRPYAKYLIETQRSVNP----NFARFDDEVSNSSLRHGID 598

Human   884 SALDAEI----RAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEE------- 937
            |.|...:    |....::|.::   .|:.:|       :|.:|::|.:::.|:||..:
Yeast   599 SFLSQGVSRPGRYSLLVREIIH---FSDPVT-------DKDDLQMLMKVQDLLKDLMKRIDRASG 653

Human   938 -------------------------LRSEK-GIEHQDSQHSFLAFLN----TPTDALDQFEDSFS 972
                                     |.:|| .|:|:       ..|:    ..|||      |||
Yeast   654 AAQDRYDVKVLKQKILFKNEYVNLGLNNEKRKIKHE-------GLLSRKDVNKTDA------SFS 705

Human   973 SS-----SSSLIDFLDDRSPSCTPASKGRRTDPVENTYVWNPSVKFHIQSRSTSPSTSSEAEPVK 1032
            ..     ..:::.||..::.:                       |:|                ..
Yeast   706 GDIQFYLLDNMLLFLKSKAVN-----------------------KWH----------------QH 731

Human  1033 TVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVC 1097
            ||...|:.:  |.|..  || :...||        :|.:.|.              ...||..|.
Yeast   732 TVFQRPIPL--PLLFI--CP-AEDMPP--------IKRYVTE--------------NPNCSAGVL 769

Human  1098 GFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEG-------HVRIPKPAG----VKKG 1151
                             :|..||.     :|:..|..||.|       .:..|:|||    ::|.
Yeast   770 -----------------LPQYQTS-----NPKNAIVFAYYGTKQQYQVTLYAPQPAGLQTLIEKV 812

Human  1152 WQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRV 1216
            .|....::.:.|...:....|:.....:..::|.|:.             :.||.:
Yeast   813 KQEQKRLLDETKHITFKQMVGQFFHSYINTNRVNDVL-------------ICHAGK--------- 855

Human  1217 TASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKK-----NKFRDRSVYVPKEAYDSTLP 1276
              ..|.|:|....:|..|.:.|:|     .:..||||...     .:::...:.:.|:.|...|.
Yeast   856 --ILLVATNMGLFVLNYATSINQK-----PVHLLHKISISQISVLEEYKVMILLIDKKLYGCPLD 913

Human  1277 LIKTTQAAAIIDHERIALGNEEGLF-VVHVTKD------EIIRVGDNKKIHQIE-LIPNDQLVAV 1333
            :|...:.|..:..:     |.:.|| .|.:.||      .||.:. :..:|.:: ||.|..:...
Yeast   914 VIDDAENADFLFRK-----NSKVLFKYVAMFKDGFCNGKRIIMIA-HHFLHAVQLLIVNPLIFDF 972

Human  1334 ISG---RNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELF 1395
            .||   :|....|...| :|.....|..| |.|                 :|:..|:.:
Yeast   973 NSGNFKKNLKAGLVDFS-VDSEPLSFSFL-ENK-----------------ICIGCKKNI------ 1012

Human  1396 QSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGF-LRYPLNGEGNPYSMLHSNDHTLSFIAHQ 1459
                     |.:.||           ::|  .::|| :|..||        ||.| ..|:.:..:
Yeast  1013 ---------KILNVP-----------EVC--DKNGFKMRELLN--------LHDN-KVLANMYKE 1046

Human  1460 PMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELM-WPANPSSCCYNAPYLSVYSENAVDI 1523
            ....:....|.:..: .||..:..:.:.||:|...:... |...|.....:.||:...:.|.::|
Yeast  1047 TFKVVSMFPIKNSTF-ACFPELCFFLNKQGKREETKGCFHWEGEPEQFACSYPYIVAINSNFIEI 1110

Human  1524 FDVNSMEWIQTLPLKKVRPLNNEGSLNLL------GLETIRLIYF 1562
            ..:.:.|.::.:...|:|.|.:.....|.      |.|.|.|:.|
Yeast  1111 RHIENGELVRCVLGNKIRMLKSYAKKILYCYEDPQGFEIIELLNF 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDC42BPA	NP_001374479.1	STKc_MRCK_alpha	4..412	CDD:270773	19/76 (25%)
		Mplasa_alph_rch	<442..954	CDD:275316	102/584 (17%)
		KELK	529..608	CDD:464876	8/78 (10%)
		DMPK_coil	881..941	CDD:117396	13/95 (14%)
		C1_MRCKalpha	1062..1121	CDD:410414	7/58 (12%)
		PH_MRCK	1123..1257	CDD:269949	28/149 (19%)
		CNH	1288..1546	CDD:459938	53/270 (20%)
ROM1	NP_011584.2	ROM1	1..1155	CDD:227709	244/1343 (18%)