Protein Alignment PCGF1 and SPCC548.05c

DIOPT Version :9

• Sequence 1: NP_116062.2
• Gene: PCGF1 / 84759
• HGNCID: 17615
• Length: 259
• Species: Homo sapiens
• Sequence 2: NP_587745.1
• Gene: SPCC548.05c / 2539314
• PomBaseID: SPCC548.05c
• Length: 468
• Species: Schizosaccharomyces pombe
• Alignment Length: 226
• Identity: 47/226 - (20%)
• Similarity: 78/226 - (34%)
• Gaps: 66/226 - (29%)

Human     4 PQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKD----------LNEHIVCCLCAGYFVDAT 58
            ||......|.....|:   ||...:.:..|.:.:|.|          :.:.:.|.:|........
pombe    35 PQSNSTTFASSDATQM---YKKSRISSNSENKKQIPDTKTLLETFQKIKKTLECPICTEALQRPF 96

Human    59 TITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRI 123
            | |.|.||:|..|::.:|:.||.||.|..|:: |||.....:..:|..:
pombe    97 T-THCGHTYCYECLLNWLKESKSCPTCRQKLY-TQPSPAYLVYEIMNVV---------------- 143

Human   124 REFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSV 186
                                |.||.|.|....:.:.|     .:|..:..:.:...:|.:  :|:
pombe   144 --------------------AASNSGFPLVGINENPA-----KKQKEVLFDGMFKQEDSHYPRSI 183

Human   187 LQNKYVRCSVRAEVRHLRRVLCHRLMLNPQH 217
            |        |.:|...||...|...:.||.|
pombe   184 L--------VDSEDGVLRCARCQWELENPYH 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCGF1	NP_116062.2	RING-HC_PCGF1	44..86	CDD:319647	14/41 (34%)
		RING-HC finger (C3HC4-type)	47..85	CDD:319647	14/37 (38%)
		Required for repressor activity	86..247		23/134 (17%)
		Required for the interaction with the KDM2B-SKP1 heterodimeric complex. /evidence=ECO:0000269|PubMed:27568929	150..255		14/70 (20%)
		RAWUL_PCGF1	166..253	CDD:340601	12/54 (22%)
		RING-finger and WD40-associated ubiquitin-like domain (RAWUL), sufficient for interaction with BCOR and BCORL1. /evidence=ECO:0000269|PubMed:23523425, ECO:0000269|PubMed:27568929	167..255		12/53 (23%)
SPCC548.05c	NP_587745.1	RING	84..126	CDD:238093	15/42 (36%)
		COG2888	<193..213	CDD:268082	5/14 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910