Protein Alignment USP30 and not

DIOPT Version :10

• Sequence 1: XP_016875537.1
• Gene: USP30 / 84749
• HGNCID: 20065
• Length: 554
• Species: Homo sapiens
• Sequence 2: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 119/523 - (22%)
• Similarity: 176/523 - (33%)
• Gaps: 193/523 - (36%)

Human    50 YVIWGPITER------KKRRKGLVP-------GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTS 101
            :|.|.|.|:.      ..||:.:.|       ||:|||.|||||.::|.|...|.    |.::..
  Fly   334 WVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPL----LSDYFM 394

Human   102 QYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDD--EVLDASCLLDVLRMYRWQISSFEEQDAHE 164
            ....|.....||:.|...:..|.     ||....  ..|....||.::..:...::.:|:|||||
  Fly   395 SDRHDCGSKSSHKCLVCEVSRLF-----QEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHE 454

Human   165 LFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRT---RGSPHPTSNHWKSQ----- 221
            .|   .::|:        |.|.   |.::.::|...|..:..:   ..|.:.:|:|...|
  Fly   455 FF---IATLD--------VLHR---HCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCII 505

Human   222 -HPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGH----PLTLDHCLHHFISSE---S 278
             ..|.|.|.|::||:.|...| ..:|.|..:||.: ..|..|    |.||..||..:..:|   |
  Fly   506 DQIFTGMLQSDVVCQACNGVS-TTYDPFWDISLDL-GETTTHGGVTPKTLIDCLERYTRAEHLGS 568

Human   279 VRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKR--HE 341
            ...:.|..|.             .:|.:|  ||..|..||..:..||:|.   .|...:.|  ..
  Fly   569 AAKIKCSTCK-------------SYQEST--KQFSLRTLPSVVSFHLKRF---EHSALIDRKISS 615

Human   342 HVQFN-EFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPGVCARGADAAGIFSTE 405
            .:||. ||.|                                     ||            |.:|
  Fly   616 FIQFPVEFDM-------------------------------------TP------------FMSE 631

Human   406 KSSLASPPSGSLMTGAQGLYNVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSST 470
            |.:            |.|                                              .
  Fly   632 KKN------------AYG----------------------------------------------D 638

Human   471 YLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLF 535
            :.|.|.|||.|.|.:.:||:..|.|         ...:.|:...|..:..|||::||.|..||||
  Fly   639 FRFSLYAVVNHVGTIDTGHYTAYVR---------HQKDTWVKCDDHVITMASLKQVLDSEGYLLF 694

Human   536 YER 538
            |.:
  Fly   695 YHK 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USP30	XP_016875537.1	Peptidase_C19F	69..537	CDD:239127	111/488 (23%)
		UBP12	<69..>265	CDD:227847	56/210 (27%)
not	NP_001401041.1	zf-UBP	253..310	CDD:460464
		Peptidase_C19D	365..696	CDD:239125	111/489 (23%)