DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OGT and ogt

DIOPT Version :10

Sequence 1:NP_858058.1 Gene:OGT / 8473 HGNCID:8127 Length:1046 Species:Homo sapiens
Sequence 2:XP_012823955.1 Gene:ogt / 553157 XenbaseID:XB-GENE-966145 Length:1045 Species:Xenopus tropicalis


Alignment Length:1046 Identity:1003/1046 - (95%)
Similarity:1029/1046 - (98%) Gaps:1/1046 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIH 65
            ||:|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog     1 MAASVGSVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIH 65

Human    66 FQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 FQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 130

Human   131 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWS 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   131 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWS 195

Human   196 NLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAV 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 NLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAV 260

Human   261 VHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPT 325
            |||||||||||||||||||||||||||||||||||||||||||||||||.:||:|||||||||||
 Frog   261 VHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVVDAEECYNTALRLCPT 325

Human   326 HADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   326 HADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 390

Human   391 SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   391 SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455

Human   456 LKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFR 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   456 LKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFR 520

Human   521 KAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDK 585
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
 Frog   521 KAIAERHGNLCLDKINVLHKPPYEHPKDLKASDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDK 585

Human   586 FEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNEL 650
            |||||||||||||||||||||||||||:|||||||||||||||||||:|||:|||||||||||||
 Frog   586 FEVFCYALSPDDGTNFRVKVMAEANHFVDLSQIPCNGKAADRIHQDGVHILINMNGYTKGARNEL 650

Human   651 FALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHL 715
            |||:.||||||||||||||||.||||||:|.||||.:|||||||||||||:||||||||||||||
 Frog   651 FALKAAPIQAMWLGYPGTSGASFMDYIISDIETSPVDVAEQYSEKLAYMPNTFFIGDHANMFPHL 715

Human   716 KKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMN 780
            ||||||||||||||||||||||||||||||:|||||||||||.||.|||.| :|:|||||||||:
 Frog   716 KKKAVIDFKSNGHIYDNRIVLNGIDLKAFLESLPDVKIVKMKGPDSGDNVD-NNSALNMPVIPMS 779

Human   781 TIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYC 845
            :|||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||:|||
 Frog   780 SIAEAVIEMINRGQIQITINGFNISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAVVYC 844

Human   846 NFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEE 910
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||
 Frog   845 NFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQSRIIFSPVAPKEE 909

Human   911 HVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQE 975
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||.|||||.||:
 Frog   910 HVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGDTLASRVAASQLTCLGCPELIAKGRQD 974

Human   976 YEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPV 1040
            |||.|||||||||||||:|.||||||||||||||||||::||||||||||||:||||.||:||.|
 Frog   975 YEDTAVKLGTDLEYLKKIRSKVWKQRISSPLFNTKQYTIDLERLYLQMWEHYSAGNKTDHLIKTV 1039

Human  1041 EVTESA 1046
            |.||||
 Frog  1040 ESTESA 1045

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OGTNP_858058.1 TPR 1 21..54 32/32 (100%)
TPR repeat 24..49 CDD:276809 24/24 (100%)
PilF 32..121 CDD:442297 88/88 (100%)
TPR repeat 57..83 CDD:276809 25/25 (100%)
TPR 82..289 CDD:440225 206/206 (100%)
TPR 2 89..122 32/32 (100%)
TPR repeat 89..117 CDD:276809 27/27 (100%)
TPR repeat 122..152 CDD:276809 29/29 (100%)
TPR 3 123..156 32/32 (100%)
TPR 4 157..190 32/32 (100%)
TPR repeat 157..185 CDD:276809 27/27 (100%)
LapB 190..457 CDD:442196 263/266 (99%)
TPR 5 191..224 32/32 (100%)
TPR repeat 191..219 CDD:276809 27/27 (100%)
TPR 6 225..258 32/32 (100%)
TPR repeat 226..253 CDD:276809 26/26 (100%)
TPR 7 259..292 32/32 (100%)
TPR repeat 259..287 CDD:276809 27/27 (100%)
TPR 8 293..326 29/32 (91%)
TPR repeat 293..321 CDD:276809 24/27 (89%)
TPR 9 327..360 32/32 (100%)
TPR repeat 327..355 CDD:276809 27/27 (100%)
TPR repeat 360..390 CDD:276809 29/29 (100%)
TPR 10 361..394 32/32 (100%)
TPR 11 395..428 32/32 (100%)
TPR repeat 395..423 CDD:276809 27/27 (100%)
TPR 12 429..462 32/32 (100%)
TPR repeat 429..457 CDD:276809 27/27 (100%)
TPR 13, truncated 463..473 9/9 (100%)
DFP motif. /evidence=ECO:0000269|PubMed:27713473 464..466 1/1 (100%)
Glyco_transf_41 476..1016 CDD:404688 507/539 (94%)
Nuclear localization signal. /evidence=ECO:0000255 487..503 15/15 (100%)
Required for phosphatidylinositol 3,4,5-triphosphate binding. /evidence=ECO:0000250|UniProtKB:P56558 991..1010 16/18 (89%)
ogtXP_012823955.1 TPR repeat 24..49 CDD:276809 24/24 (100%)
PilF 32..121 CDD:442297 88/88 (100%)
TPR repeat 57..83 CDD:276809 25/25 (100%)
TPR 82..289 CDD:440225 206/206 (100%)
TPR repeat 89..117 CDD:276809 27/27 (100%)
TPR repeat 122..152 CDD:276809 29/29 (100%)
TPR repeat 157..185 CDD:276809 27/27 (100%)
LapB 190..457 CDD:442196 263/266 (99%)
TPR repeat 191..219 CDD:276809 27/27 (100%)
TPR repeat 226..253 CDD:276809 26/26 (100%)
TPR repeat 259..287 CDD:276809 27/27 (100%)
TPR repeat 293..321 CDD:276809 24/27 (89%)
TPR repeat 327..355 CDD:276809 27/27 (100%)
TPR repeat 360..390 CDD:276809 29/29 (100%)
TPR repeat 395..423 CDD:276809 27/27 (100%)
TPR repeat 429..457 CDD:276809 27/27 (100%)
Glyco_transf_41 476..1015 CDD:404688 507/539 (94%)

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