DRSC/TRiP Functional Genomics Resources

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Protein Alignment OGT and BBS4

DIOPT Version :9

Sequence 1:NP_858058.1 Gene:OGT / 8473 HGNCID:8127 Length:1046 Species:Homo sapiens
Sequence 2:NP_610636.1 Gene:BBS4 / 36167 FlyBaseID:FBgn0033578 Length:486 Species:Drosophila melanogaster


Alignment Length:339 Identity:69/339 - (20%)
Similarity:133/339 - (39%) Gaps:50/339 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   198 GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA--LSLSPNHAV 260
            |.:...:|....|:.|.:|:..|:|..::.|..:|..|.....|.:|:..:..|  .|...:|.:
  Fly    74 GLIDREEGNHIEALRHLQKSAELNPRNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEI 138

Human   261 VH--GNL--------------------ACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANAL 303
            .|  |.|                    |..|:|     ||:.:.|:.        ::|..||...
  Fly   139 YHYLGELLYRAATTQSQKDVASQQQDEARTYFE-----LAVQSGRKL--------ESYVRLAELY 190

Human   304 KEKGSVAEAEDCYNTALRLCPTHADSLNNLA-------NIKREQGNIEEAVRLYRKALEVFPEFA 361
            ::.....:|.:.....|.|.|.:::.|..::       ..::....:.|.|.:.||.   .|:..
  Fly   191 RKDKQYQKAIEILENCLHLTPENSEVLIEISVLYLKINETQKAHDRLAEVVSIERKC---SPKGL 252

Human   362 AAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINP 426
            .|   ..::||.:..:..||..|.:.....|..|:.::|:|....:.|....|:....:::.::|
  Fly   253 LA---FGAILQSRNDIDGALSKYSQIANAEPEIAELWNNIGLCFFKKQKFIVAISSLRKSVWLSP 314

Human   427 AFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVS 491
            ...:|..||:.|:..|.....|..:...|:.|:.|..:.|..|..||:.:.|..:....:::..|
  Fly   315 LNYNALYNLSLIYIASEQYASAFHTLAAAINLRK
DNAECYMLLGLCLRKLDDMENAFVALERASS 379

Human   492 IVADQLEKNRLPSV 505
            :...|....|.|.|
  Fly   380 MATGQQGAGRNPLV 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OGTNP_858058.1 TPR 1 21..54
PEP_TPR_lipo <22..>465 CDD:274350 59/297 (20%)
TPR repeat 24..49 CDD:276809
TPR repeat 57..83 CDD:276809
TPR 2 89..122
TPR repeat 89..117 CDD:276809
TPR repeat 122..152 CDD:276809
TPR 3 123..156
TPR 4 157..190
TPR repeat 157..185 CDD:276809
TPR 5 191..224 7/25 (28%)
TPR repeat 191..219 CDD:276809 5/20 (25%)
TPR 6 225..258 7/34 (21%)
TPR repeat 226..253 CDD:276809 6/28 (21%)
TPR 7 259..292 9/54 (17%)
TPR repeat 259..287 CDD:276809 9/49 (18%)
TPR 8 293..326 7/32 (22%)
TPR repeat 293..321 CDD:276809 4/27 (15%)
TPR 9 327..360 6/39 (15%)
TPR repeat 327..355 CDD:276809 5/34 (15%)
TPR repeat 360..390 CDD:276809 6/29 (21%)
TPR 10 361..394 7/32 (22%)
TPR 11 395..428 6/32 (19%)
TPR repeat 395..423 CDD:276809 5/27 (19%)
TPR 12 429..462 8/32 (25%)
TPR repeat 429..457 CDD:276809 7/27 (26%)
TPR 13, truncated 463..473 2/9 (22%)
Nuclear localization signal. /evidence=ECO:0000255 487..503 3/15 (20%)
Glyco_transf_41 556..1024 CDD:372753
Required for phosphatidylinositol 3,4,5-triphosphate binding 991..1010
BBS4NP_610636.1 TPR_12 63..127 CDD:290160 12/52 (23%)
TPR repeat 68..95 CDD:276809 5/20 (25%)
TPR_12 97..175 CDD:290160 17/82 (21%)
TPR repeat 100..130 CDD:276809 6/29 (21%)
TPR repeat 136..175 CDD:276809 9/43 (21%)
TPR repeat 179..209 CDD:276809 5/37 (14%)
TPR_19 190..254 CDD:291240 10/66 (15%)
TPR repeat 214..242 CDD:276809 2/27 (7%)
TPR repeat 249..277 CDD:276809 7/30 (23%)
TPR_11 283..348 CDD:290150 14/64 (22%)
TPR repeat 283..311 CDD:276809 5/27 (19%)
TPR repeat 316..346 CDD:276809 7/29 (24%)
TPR repeat 351..377 CDD:276809 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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