DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OGT and ogt.1

DIOPT Version :10

Sequence 1:NP_858058.1 Gene:OGT / 8473 HGNCID:8127 Length:1046 Species:Homo sapiens
Sequence 2:NP_001017359.1 Gene:ogt.1 / 337685 ZFINID:ZDB-GENE-030131-9631 Length:1062 Species:Danio rerio


Alignment Length:1063 Identity:974/1063 - (91%)
Similarity:1020/1063 - (95%) Gaps:20/1063 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIH 65
            |||||||||||||||||:|||||||||||||||:|||||||||||||||||||||||||||||||
Zfish     1 MASSVGNVADSTEPTKRVLSFQGLAELAHREYQSGDFEAAERHCMQLWRQEPDNTGVLLLLSSIH 65

Human    66 FQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 130
            |||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
Zfish    66 FQCRRLDRSAHFSTLAIKQNPMLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 130

Human   131 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWS 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   131 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWS 195

Human   196 NLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAV 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||
Zfish   196 NLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAGYLRALSLSPNHAV 260

Human   261 VHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPT 325
            |||||||||||||||||||||||||||||||||||||||||||||||:|:|||:|||||||||||
Zfish   261 VHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGNVSEAEECYNTALRLCPT 325

Human   326 HADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 390
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Zfish   326 HADSLNNLANIKREQGNIEEAVQLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 390

Human   391 SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   391 SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455

Human   456 LKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFR 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   456 LKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFR 520

Human   521 KAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDK 585
            ||||||||||||||||.||||.||||||||.|.|||||||:|||||||||||||||||||||.:|
Zfish   521 KAIAERHGNLCLDKINALHKPAYEHPKDLKASSGRLRVGYISSDFGNHPTSHLMQSIPGMHNSEK 585

Human   586 FEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNEL 650
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Zfish   586 FEVFCYALSPDDGTNFRVKVMAEAHHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNEL 650

Human   651 FALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHL 715
            |||||||||||||.|||||||.|||||::|:.|||.||||||||||||||:||||||||||||||
Zfish   651 FALRPAPIQAMWLAYPGTSGAPFMDYIVSDKATSPIEVAEQYSEKLAYMPNTFFIGDHANMFPHL 715

Human   716 KKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMN 780
            ||||||||||||||:|||||||||||||||:||||||:|||:| ||.:.|| ||.||:||:||||
Zfish   716 KKKAVIDFKSNGHIFDNRIVLNGIDLKAFLESLPDVKVVKMEC-DGQEVAD-SNGALSMPIIPMN 778

Human   781 TIAEAVIEMINRGQIQITINGFSISNGLATT----------------QINNKAATGEEVPRTIIV 829
            |.|||:|.|||:||||:|||||::|||||||                ||||||||||||||||:|
Zfish   779 TAAEAIINMINQGQIQVTINGFTVSNGLATTQIFTVEEVVVSGTVALQINNKAATGEEVPRTIVV 843

Human   830 TTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMG 894
            |||||||||||:||||||||||||||.||||||||||||||||:|||||||||||||||||||:|
Zfish   844 TTRSQYGLPEDSIVYCNFNQLYKIDPPTLQMWANILKRVPNSVIWLLRFPAVGEPNIQQYAQNLG 908

Human   895 LPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQ 959
            ||.:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   909 LPASRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQ 973

Human   960 LTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMW 1024
            ||||||.||||::||||||:|||||||:|:|||||.:||||||.|||||||||||:||:||||||
Zfish   974 LTCLGCPELIAQSRQEYEDVAVKLGTDMEFLKKVRARVWKQRICSPLFNTKQYTMDLEKLYLQMW 1038

Human  1025 EHYAAGNKPDHMIK--PVEVTES 1045
            |::|:|.||||::|  .:|.:||
Zfish  1039 ENHASGGKPDHLVKMQSLETSES 1061

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OGTNP_858058.1 TPR 1 21..54 31/32 (97%)
TPR repeat 24..49 CDD:276809 23/24 (96%)
PilF 32..121 CDD:442297 86/88 (98%)
TPR repeat 57..83 CDD:276809 25/25 (100%)
TPR 82..289 CDD:440225 204/206 (99%)
TPR 2 89..122 32/32 (100%)
TPR repeat 89..117 CDD:276809 27/27 (100%)
TPR repeat 122..152 CDD:276809 29/29 (100%)
TPR 3 123..156 32/32 (100%)
TPR 4 157..190 32/32 (100%)
TPR repeat 157..185 CDD:276809 27/27 (100%)
LapB 190..457 CDD:442196 261/266 (98%)
TPR 5 191..224 32/32 (100%)
TPR repeat 191..219 CDD:276809 27/27 (100%)
TPR 6 225..258 31/32 (97%)
TPR repeat 226..253 CDD:276809 25/26 (96%)
TPR 7 259..292 32/32 (100%)
TPR repeat 259..287 CDD:276809 27/27 (100%)
TPR 8 293..326 29/32 (91%)
TPR repeat 293..321 CDD:276809 24/27 (89%)
TPR 9 327..360 31/32 (97%)
TPR repeat 327..355 CDD:276809 26/27 (96%)
TPR repeat 360..390 CDD:276809 29/29 (100%)
TPR 10 361..394 32/32 (100%)
TPR 11 395..428 32/32 (100%)
TPR repeat 395..423 CDD:276809 27/27 (100%)
TPR 12 429..462 32/32 (100%)
TPR repeat 429..457 CDD:276809 27/27 (100%)
TPR 13, truncated 463..473 9/9 (100%)
DFP motif. /evidence=ECO:0000269|PubMed:27713473 464..466 1/1 (100%)
Glyco_transf_41 476..1016 CDD:404688 488/555 (88%)
Nuclear localization signal. /evidence=ECO:0000255 487..503 15/15 (100%)
Required for phosphatidylinositol 3,4,5-triphosphate binding. /evidence=ECO:0000250|UniProtKB:P56558 991..1010 15/18 (83%)
ogt.1NP_001017359.1 TPR repeat 24..49 CDD:276809 23/24 (96%)
PilF 32..121 CDD:442297 86/88 (98%)
TPR repeat 57..83 CDD:276809 25/25 (100%)
TPR 82..289 CDD:440225 204/206 (99%)
TPR repeat 89..117 CDD:276809 27/27 (100%)
TPR repeat 122..152 CDD:276809 29/29 (100%)
TPR repeat 157..185 CDD:276809 27/27 (100%)
LapB 190..457 CDD:442196 261/266 (98%)
TPR repeat 191..219 CDD:276809 27/27 (100%)
TPR repeat 226..253 CDD:276809 25/26 (96%)
TPR repeat 259..287 CDD:276809 27/27 (100%)
TPR repeat 293..321 CDD:276809 24/27 (89%)
TPR repeat 326..356 CDD:276809 28/29 (97%)
TPR repeat 361..389 CDD:276809 27/27 (100%)
TPR repeat 395..423 CDD:276809 27/27 (100%)
TPR repeat 429..457 CDD:276809 27/27 (100%)
Glyco_transf_41 476..1030 CDD:404688 488/555 (88%)

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