DRSC/TRiP Functional Genomics Resources

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Protein Alignment OGT and sfc4

DIOPT Version :10

Sequence 1:NP_858058.1 Gene:OGT / 8473 HGNCID:8127 Length:1046 Species:Homo sapiens
Sequence 2:NP_587924.1 Gene:sfc4 / 2539187 PomBaseID:SPCC16C4.14C Length:1006 Species:Schizosaccharomyces pombe


Alignment Length:498 Identity:95/498 - (19%)
Similarity:162/498 - (32%) Gaps:162/498 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   103 GQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAG---DMEGAVQAYVSALQYNPDLYCVRSDLG 164
            |.:.|.::..|:...:...|:..    .:||.|.|   |.|...:.......::........|:.
pombe    34 GYISEIVDEARNVSEVDAKFLGD----TSALQAEGLWSDEESDYEGSDDESNFSKTASRTEDDIA 94

Human   165 N-----LLKAL-----------GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHH 213
            |     .|||:           ||...::|..|.::|.|...::|    ..:|..:|....|...
pombe    95 NEEWEENLKAVAGFRKVRKGHKGRGRVSRADMLPSVEVQQMLSLA----NHLFAQEGNFDEAQKL 155

Human   214 FEKAVTLDPNFLDAYINLGNVLKE---ARI-FDRAVAAYLRALSLSP-NHAVVHGNLACVYYEQG 273
            .|:.|.:|.|.:.|:..||...::   .|: .::.:.|::.|..|.| :|.:.   ..|....:.
pombe   156 AEEIVRIDNNVIAAWKMLGECHRQRGNGRVNIEKCLIAWMAAAHLKPKDHELW---FTCAKLSES 217

Human   274 L--IDLAIDTYRRAIELQP----HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNN 332
            |  .|.|...|.||:..:|    .......|.:...||.||:.:|.:.:...|:..|.:|..|.|
pombe   218 LEFWDQADYCYNRAVSAKPPNKSELKKYIWNRSVLNKEHGSLKKAAEGFKFLLQSSPYNASILKN 282

Human   333 LANI------KRE-------------------QGN---------------------------IEE 345
            ||.|      .||                   .||                           |..
pombe   283 LAEIYIKIHAPREILKQFEIAWKYFYQYPAPPIGNDIFDLPTLNLYAELLLLDHQWSNLIRLINR 347

Human   346 AVRLYR--------------------KALEVFPEFAAAHSNLASVL-------------QQQGKL 377
            .||.:|                    :....||..:..|:|..:.|             .:.|:|
pombe   348 GVRWFRGRKSESFWDEFDDDREWDVDERRREFPNASEEHTNKEAYLLPHLFRTKLGIARLKTGEL 412

Human   378 QEALMHYKEAIRISPTF--------ADAYS----------------------------NMGNTLK 406
            .||.:|:.....:.|.:        |.||.                            |||....
pombe   413 PEAELHFSVIKNLPPDYAWGMLYDIAKAYMDIERLDLALEYFVLICNHEPAQNIGLWYNMGVCYL 477

Human   407 EMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAI 449
            |:::.:.|.||....:.::.:..:|...||.|::...|...|:
pombe   478 ELKEYEHAQQCMEAILIVDNSNTNALIKLAEINELQDNRDAAL 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OGTNP_858058.1 TPR 1 21..54
TPR repeat 24..49 CDD:276809
PilF 32..121 CDD:442297 3/17 (18%)
TPR repeat 57..83 CDD:276809
TPR 82..289 CDD:440225 45/211 (21%)
TPR 2 89..122 3/18 (17%)
TPR repeat 89..117 CDD:276809 3/13 (23%)
TPR repeat 122..152 CDD:276809 7/32 (22%)
TPR 3 123..156 6/35 (17%)
TPR 4 157..190 11/48 (23%)
TPR repeat 157..185 CDD:276809 9/43 (21%)
LapB 190..457 CDD:442196 74/392 (19%)
TPR 5 191..224 7/32 (22%)
TPR repeat 191..219 CDD:276809 5/27 (19%)
TPR 6 225..258 8/37 (22%)
TPR repeat 226..253 CDD:276809 6/30 (20%)
TPR 7 259..292 8/38 (21%)
TPR repeat 259..287 CDD:276809 7/29 (24%)
TPR 8 293..326 8/32 (25%)
TPR repeat 293..321 CDD:276809 6/27 (22%)
TPR 9 327..360 16/104 (15%)
TPR repeat 327..355 CDD:276809 14/99 (14%)
TPR repeat 360..390 CDD:276809 8/42 (19%)
TPR 10 361..394 9/45 (20%)
TPR 11 395..428 10/60 (17%)
TPR repeat 395..423 CDD:276809 10/55 (18%)
TPR 12 429..462 6/21 (29%)
TPR repeat 429..457 CDD:276809 6/21 (29%)
TPR 13, truncated 463..473
DFP motif. /evidence=ECO:0000269|PubMed:27713473 464..466
Glyco_transf_41 476..1016 CDD:404688
Nuclear localization signal. /evidence=ECO:0000255 487..503
Required for phosphatidylinositol 3,4,5-triphosphate binding. /evidence=ECO:0000250|UniProtKB:P56558 991..1010
sfc4NP_587924.1 TPR repeat 132..161 CDD:276809 6/32 (19%)
TPR 142..>306 CDD:440225 40/166 (24%)
TPR repeat 166..200 CDD:276809 6/33 (18%)
TPR repeat 205..233 CDD:276809 8/30 (27%)
TPR repeat 243..271 CDD:276809 6/27 (22%)
TPR 402..600 CDD:440225 22/119 (18%)
TPR repeat 434..459 CDD:276809 3/24 (13%)
TPR repeat 465..495 CDD:276809 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

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